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O93830

- PGTB2_CANAX

UniProt

O93830 - PGTB2_CANAX

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Protein

Geranylgeranyl transferase type-2 subunit beta

Gene
BET2
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi249 – 2491Zinc By similarity
Metal bindingi249 – 2491Zinc; catalytic By similarity
Metal bindingi251 – 2511Zinc By similarity
Metal bindingi251 – 2511Zinc; catalytic By similarity
Metal bindingi301 – 3011Zinc By similarity
Metal bindingi301 – 3011Zinc; via tele nitrogen; catalytic By similarity

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Short name:
PGGT
YPT1/SEC4 proteins geranylgeranyltransferase subunit beta
Gene namesi
Name:BET2
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Geranylgeranyl transferase type-2 subunit betaPRO_0000119776Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliO93830.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 5541PFTB 1Add
BLAST
Repeati62 – 10443PFTB 2Add
BLAST
Repeati122 – 16342PFTB 3Add
BLAST
Repeati170 – 21142PFTB 4Add
BLAST
Repeati223 – 26442PFTB 5Add
BLAST
Repeati271 – 31343PFTB 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 1983Geranylgeranyl diphosphate binding By similarity
Regioni243 – 25513Geranylgeranyl diphosphate binding By similarityAdd
BLAST

Sequence similaritiesi

Contains 6 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

O93830-1 [UniParc]FASTAAdd to Basket

« Hide

MSNLPPDEKV ILFDKSKHVQ YIVEQESHRS FEYWLSEHLR MNGLYWGVTA    50
LITMNELSAL AQQDVIDYIM LCWDDKTGAF GSFPKHDGHI LSTLSALQVL 100
KIYDQELTVL NDNNESSNGN KRERLIKFIT GLQLPDGSFQ GDKYGEVDTR 150
FVYTAVSSLS LLNALTDSIA DTASAFIMQC FNFDGGFGLI PGSESHAAQV 200
FTCVGALAIM NKLDLLDVEN KKVKLIDWLT ERQVLPSGGF NGRPEKLPDV 250
CYSWWVLSSL SILKRKNWVD LKILENFILT CQDLENGGFS DRPGNQTDVY 300
HTCFAIAGLS LIDYKKYGFK EIDPVYCMPV EVTSKFVRRS A 341
Length:341
Mass (Da):38,460
Last modified:May 1, 1999 - v1
Checksum:i24A89E11FF911488
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021171 Genomic DNA. Translation: BAA35193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021171 Genomic DNA. Translation: BAA35193.1 .

3D structure databases

ProteinModelPortali O93830.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5029.

Family and domain databases

Gene3Di 1.50.10.20. 1 hit.
InterProi IPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
PANTHERi PTHR11774:SF9. PTHR11774:SF9. 1 hit.
Pfami PF00432. Prenyltrans. 2 hits.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of BET2 gene from Candida albicans."
    Ishii N., Aoki Y., Arisawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Entry informationi

Entry nameiPGTB2_CANAX
AccessioniPrimary (citable) accession number: O93830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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