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O93830 (PGTB2_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit beta

EC=2.5.1.60
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name=GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Short name=PGGT
YPT1/SEC4 proteins geranylgeranyltransferase subunit beta
Gene names
Name:BET2
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit beta family.

Contains 6 PFTB repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Geranylgeranyl transferase type-2 subunit beta
PRO_0000119776

Regions

Repeat15 – 5541PFTB 1
Repeat62 – 10443PFTB 2
Repeat122 – 16342PFTB 3
Repeat170 – 21142PFTB 4
Repeat223 – 26442PFTB 5
Repeat271 – 31343PFTB 6
Region196 – 1983Geranylgeranyl diphosphate binding By similarity
Region243 – 25513Geranylgeranyl diphosphate binding By similarity

Sites

Metal binding2491Zinc By similarity
Metal binding2491Zinc; catalytic By similarity
Metal binding2511Zinc By similarity
Metal binding2511Zinc; catalytic By similarity
Metal binding3011Zinc By similarity
Metal binding3011Zinc; via tele nitrogen; catalytic By similarity

Sequences

Sequence LengthMass (Da)Tools
O93830 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 24A89E11FF911488

FASTA34138,460
        10         20         30         40         50         60 
MSNLPPDEKV ILFDKSKHVQ YIVEQESHRS FEYWLSEHLR MNGLYWGVTA LITMNELSAL 

        70         80         90        100        110        120 
AQQDVIDYIM LCWDDKTGAF GSFPKHDGHI LSTLSALQVL KIYDQELTVL NDNNESSNGN 

       130        140        150        160        170        180 
KRERLIKFIT GLQLPDGSFQ GDKYGEVDTR FVYTAVSSLS LLNALTDSIA DTASAFIMQC 

       190        200        210        220        230        240 
FNFDGGFGLI PGSESHAAQV FTCVGALAIM NKLDLLDVEN KKVKLIDWLT ERQVLPSGGF 

       250        260        270        280        290        300 
NGRPEKLPDV CYSWWVLSSL SILKRKNWVD LKILENFILT CQDLENGGFS DRPGNQTDVY 

       310        320        330        340 
HTCFAIAGLS LIDYKKYGFK EIDPVYCMPV EVTSKFVRRS A 

« Hide

References

[1]"Molecular cloning of BET2 gene from Candida albicans."
Ishii N., Aoki Y., Arisawa M.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021171 Genomic DNA. Translation: BAA35193.1.

3D structure databases

ProteinModelPortalO93830.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5029.

Family and domain databases

Gene3D1.50.10.20. 1 hit.
InterProIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMSSF48239. SSF48239. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGTB2_CANAX
AccessionPrimary (citable) accession number: O93830
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families