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Protein

Geranylgeranyl transferase type-2 subunit beta

Gene

BET2

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 (By similarity).By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi249 – 2491ZincBy similarity
Metal bindingi249 – 2491Zinc; catalyticBy similarity
Metal bindingi251 – 2511ZincBy similarity
Metal bindingi251 – 2511Zinc; catalyticBy similarity
Metal bindingi301 – 3011ZincBy similarity
Metal bindingi301 – 3011Zinc; via tele nitrogen; catalyticBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit beta (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit beta
Short name:
GGTase-II-beta
Type II protein geranyl-geranyltransferase subunit beta
Short name:
PGGT
YPT1/SEC4 proteins geranylgeranyltransferase subunit beta
Gene namesi
Name:BET2
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Geranylgeranyl transferase type-2 subunit betaPRO_0000119776Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliO93830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati15 – 5541PFTB 1Add
BLAST
Repeati62 – 10443PFTB 2Add
BLAST
Repeati122 – 16342PFTB 3Add
BLAST
Repeati170 – 21142PFTB 4Add
BLAST
Repeati223 – 26442PFTB 5Add
BLAST
Repeati271 – 31343PFTB 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni196 – 1983Geranylgeranyl diphosphate bindingBy similarity
Regioni243 – 25513Geranylgeranyl diphosphate bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 6 PFTB repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5029.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.

Sequencei

Sequence statusi: Complete.

O93830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLPPDEKV ILFDKSKHVQ YIVEQESHRS FEYWLSEHLR MNGLYWGVTA
60 70 80 90 100
LITMNELSAL AQQDVIDYIM LCWDDKTGAF GSFPKHDGHI LSTLSALQVL
110 120 130 140 150
KIYDQELTVL NDNNESSNGN KRERLIKFIT GLQLPDGSFQ GDKYGEVDTR
160 170 180 190 200
FVYTAVSSLS LLNALTDSIA DTASAFIMQC FNFDGGFGLI PGSESHAAQV
210 220 230 240 250
FTCVGALAIM NKLDLLDVEN KKVKLIDWLT ERQVLPSGGF NGRPEKLPDV
260 270 280 290 300
CYSWWVLSSL SILKRKNWVD LKILENFILT CQDLENGGFS DRPGNQTDVY
310 320 330 340
HTCFAIAGLS LIDYKKYGFK EIDPVYCMPV EVTSKFVRRS A
Length:341
Mass (Da):38,460
Last modified:May 1, 1999 - v1
Checksum:i24A89E11FF911488
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021171 Genomic DNA. Translation: BAA35193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021171 Genomic DNA. Translation: BAA35193.1.

3D structure databases

ProteinModelPortaliO93830.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG5029.

Family and domain databases

Gene3Di1.50.10.20. 1 hit.
InterProiIPR001330. Prenyltrans.
IPR026873. Ptb1.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PANTHERiPTHR11774:SF9. PTHR11774:SF9. 1 hit.
PfamiPF00432. Prenyltrans. 2 hits.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of BET2 gene from Candida albicans."
    Ishii N., Aoki Y., Arisawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Entry informationi

Entry nameiPGTB2_CANAX
AccessioniPrimary (citable) accession number: O93830
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.