O93829 (PGTA_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl transferase type-2 subunit alpha
EC=2.5.1.60

Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha

Gene names

Name:

BET4

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats.

Ontologies

Keywords
Domain	Repeat
Molecular function	Prenyltransferase Transferase
Gene Ontology (GO)
Biological process	protein prenylation Inferred from electronic annotation. Source: InterPro
Molecular function	Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Geranylgeranyl transferase type-2 subunit alpha		PRO_0000119755
Regions
	Repeat	45 – 79	35	PFTA 1
	Repeat	92 – 126	35	PFTA 2
	Repeat	131 – 165	35	PFTA 3
	Repeat	177 – 211	35	PFTA 4
	Repeat	242 – 276	35	PFTA 5
	Compositional bias	214 – 221	8	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	O93829 [UniParc]. Last modified May 1, 1999. Version 1. Checksum: 69DC54570B3E9FF0	FASTA	371	44,462
	10 20 30 40 50 60 MQHGIKRVKL SEEAKRLKLE KDQIKIKNYR QLTDEIFELR ANENYSDEAL IKTNELLIIN 70 80 90 100 110 120 PEFYTIWNYR REILINNYSS SNDKDDQIYE DILNQDLNFV LVQLKKFPKC YWIWNHRRWL 130 140 150 160 170 180 LFELVKLGKV NWKYEFGVVS KLLDLDQRNF HGWHYRRFVV KNMELECKND TTLILKINLD 190 200 210 220 230 240 EFNYTTLKIQ KDFSNFSAWH NRTKLIPKIY NLIQQQQQQQ QKDGKIFGDL PGIELFQNPI 250 260 270 280 290 300 LLLKNDLEMI KTGVYMSPED TSVWLYLYWL LTDDLFTNAF KSHQQDYMNI LHEQLQLINE 310 320 330 340 350 360 VNEMEKEDTG QDNVGCLKSM IFINALIQNE NNKPVLTEQV KSCLKQLAKI DPLRKNKYLD 370 QLAGNAPIFH H

References

[1]	"Molecular cloning of BET4 gene from Candida albicans." Ishii N., Aoki Y., Arisawa M. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB021170 Genomic DNA. Translation: BAA35192.1.
3D structure databases
ProteinModelPortal	O93829.
ModBase	Search...
Protein-protein interaction databases
STRING	O93829.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
Pfam	PF01239. PPTA. 4 hits. [Graphical view]
PROSITE	PS51147. PFTA. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGTA_CANAX

Accession

Primary (citable) accession number: O93829

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 1999
Last modified:	October 19, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program