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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

BET4

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 (By similarity).By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

  1. Rab geranylgeranyltransferase activity Source: UniProtKB
  2. Rab GTPase binding Source: UniProtKB

GO - Biological processi

  1. protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene namesi
Name:BET4
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Geranylgeranyl transferase type-2 subunit alphaPRO_0000119755Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliO93829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 7935PFTA 1Add
BLAST
Repeati92 – 12635PFTA 2Add
BLAST
Repeati131 – 16535PFTA 3Add
BLAST
Repeati177 – 21135PFTA 4Add
BLAST
Repeati242 – 27635PFTA 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi214 – 2218Poly-Gln

Sequence similaritiesi

Contains 5 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5536.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 4 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHGIKRVKL SEEAKRLKLE KDQIKIKNYR QLTDEIFELR ANENYSDEAL
60 70 80 90 100
IKTNELLIIN PEFYTIWNYR REILINNYSS SNDKDDQIYE DILNQDLNFV
110 120 130 140 150
LVQLKKFPKC YWIWNHRRWL LFELVKLGKV NWKYEFGVVS KLLDLDQRNF
160 170 180 190 200
HGWHYRRFVV KNMELECKND TTLILKINLD EFNYTTLKIQ KDFSNFSAWH
210 220 230 240 250
NRTKLIPKIY NLIQQQQQQQ QKDGKIFGDL PGIELFQNPI LLLKNDLEMI
260 270 280 290 300
KTGVYMSPED TSVWLYLYWL LTDDLFTNAF KSHQQDYMNI LHEQLQLINE
310 320 330 340 350
VNEMEKEDTG QDNVGCLKSM IFINALIQNE NNKPVLTEQV KSCLKQLAKI
360 370
DPLRKNKYLD QLAGNAPIFH H
Length:371
Mass (Da):44,462
Last modified:May 1, 1999 - v1
Checksum:i69DC54570B3E9FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021170 Genomic DNA. Translation: BAA35192.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021170 Genomic DNA. Translation: BAA35192.1.

3D structure databases

ProteinModelPortaliO93829.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG5536.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 4 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of BET4 gene from Candida albicans."
    Ishii N., Aoki Y., Arisawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Entry informationi

Entry nameiPGTA_CANAX
AccessioniPrimary (citable) accession number: O93829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.