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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

BET4

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 (By similarity).By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene namesi
Name:BET4
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197551 – 371Geranylgeranyl transferase type-2 subunit alphaAdd BLAST371

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliO93829.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 79PFTA 1Add BLAST35
Repeati92 – 126PFTA 2Add BLAST35
Repeati131 – 165PFTA 3Add BLAST35
Repeati177 – 211PFTA 4Add BLAST35
Repeati242 – 276PFTA 5Add BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi214 – 221Poly-Gln8

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

InterProiView protein in InterPro
IPR002088. Prenyl_trans_a.
IPR032955. RabGGTase_alpha.
PANTHERiPTHR11129:SF4. PTHR11129:SF4. 1 hit.
PfamiView protein in Pfam
PF01239. PPTA. 4 hits.
PROSITEiView protein in PROSITE
PS51147. PFTA. 5 hits.

Sequencei

Sequence statusi: Complete.

O93829-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHGIKRVKL SEEAKRLKLE KDQIKIKNYR QLTDEIFELR ANENYSDEAL
60 70 80 90 100
IKTNELLIIN PEFYTIWNYR REILINNYSS SNDKDDQIYE DILNQDLNFV
110 120 130 140 150
LVQLKKFPKC YWIWNHRRWL LFELVKLGKV NWKYEFGVVS KLLDLDQRNF
160 170 180 190 200
HGWHYRRFVV KNMELECKND TTLILKINLD EFNYTTLKIQ KDFSNFSAWH
210 220 230 240 250
NRTKLIPKIY NLIQQQQQQQ QKDGKIFGDL PGIELFQNPI LLLKNDLEMI
260 270 280 290 300
KTGVYMSPED TSVWLYLYWL LTDDLFTNAF KSHQQDYMNI LHEQLQLINE
310 320 330 340 350
VNEMEKEDTG QDNVGCLKSM IFINALIQNE NNKPVLTEQV KSCLKQLAKI
360 370
DPLRKNKYLD QLAGNAPIFH H
Length:371
Mass (Da):44,462
Last modified:May 1, 1999 - v1
Checksum:i69DC54570B3E9FF0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB021170 Genomic DNA. Translation: BAA35192.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPGTA_CANAX
AccessioniPrimary (citable) accession number: O93829
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: February 15, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families