Reviewed,
UniProtKB/Swiss-Prot O93829 (PGTA_CANAL)
Last modified
January 19, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Geranylgeranyl transferase type-2 subunit alpha EC=2.5.1.60 Alternative name(s): Geranylgeranyl transferase type II subunit alpha Type II protein geranyl-geranyltransferase subunit alpha GGTase-II-alpha PGGT YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha | ||
| Gene names |
| ||
| Organism | Candida albicans (Yeast) | ||
| Taxonomic identifier | 5476 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 371 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity. |
| Catalytic activity | Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. |
| Subunit structure | Heterodimer of an alpha and a beta subunit By similarity. |
| Sequence similarities | Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat |
| Molecular function | Prenyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | protein amino acid prenylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | Rab geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 371 | 371 | Geranylgeranyl transferase type-2 subunit alpha | PRO_0000119755 | |||||
Regions | |||||||||
| Repeat | 45 – 79 | 35 | PFTA 1 | ||||||
| Repeat | 92 – 126 | 35 | PFTA 2 | ||||||
| Repeat | 131 – 165 | 35 | PFTA 3 | ||||||
| Repeat | 177 – 211 | 35 | PFTA 4 | ||||||
| Repeat | 242 – 276 | 35 | PFTA 5 | ||||||
| Compositional bias | 214 – 221 | 8 | Poly-Gln | ||||||
Sequences
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References
| [1] | "Molecular cloning of BET4 gene from Candida albicans." Ishii N., Aoki Y., Arisawa M. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10231 / CBS 6431 / DSM 1386 / IFO 1594. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB021170 Genomic DNA. Translation: BAA35192.1. |
3D structure databases | |
| SMR | O93829. Positions 3-272, 27-360. |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 2.5.1.60. 1124. |
Family and domain databases | |
| InterPro | IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view] |
| Gene3D | G3DSA:1.25.40.120. Prenyl_trans. 1 hit. |
| Pfam | PF01239. PPTA. 4 hits. [Graphical view] |
| PROSITE | PS51147. PFTA. 5 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | PGTA_CANAL | ||||||||
| Accession | Primary (citable) accession number: O93829 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


