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O93829

- PGTA_CANAX

UniProt

O93829 - PGTA_CANAX

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Protein
Geranylgeranyl transferase type-2 subunit alpha
Gene
BET4
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity.

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

  1. Rab GTPase binding Source: UniProtKB
  2. Rab geranylgeranyltransferase activity Source: UniProtKB

GO - Biological processi

  1. protein geranylgeranylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene namesi
Name:BET4
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

GO - Cellular componenti

  1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Geranylgeranyl transferase type-2 subunit alpha
PRO_0000119755Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliO93829.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 7935PFTA 1
Add
BLAST
Repeati92 – 12635PFTA 2
Add
BLAST
Repeati131 – 16535PFTA 3
Add
BLAST
Repeati177 – 21135PFTA 4
Add
BLAST
Repeati242 – 27635PFTA 5
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi214 – 2218Poly-Gln

Sequence similaritiesi

Contains 5 PFTA repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5536.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
[Graphical view]
PfamiPF01239. PPTA. 4 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93829-1 [UniParc]FASTAAdd to Basket

« Hide

MQHGIKRVKL SEEAKRLKLE KDQIKIKNYR QLTDEIFELR ANENYSDEAL    50
IKTNELLIIN PEFYTIWNYR REILINNYSS SNDKDDQIYE DILNQDLNFV 100
LVQLKKFPKC YWIWNHRRWL LFELVKLGKV NWKYEFGVVS KLLDLDQRNF 150
HGWHYRRFVV KNMELECKND TTLILKINLD EFNYTTLKIQ KDFSNFSAWH 200
NRTKLIPKIY NLIQQQQQQQ QKDGKIFGDL PGIELFQNPI LLLKNDLEMI 250
KTGVYMSPED TSVWLYLYWL LTDDLFTNAF KSHQQDYMNI LHEQLQLINE 300
VNEMEKEDTG QDNVGCLKSM IFINALIQNE NNKPVLTEQV KSCLKQLAKI 350
DPLRKNKYLD QLAGNAPIFH H 371
Length:371
Mass (Da):44,462
Last modified:May 1, 1999 - v1
Checksum:i69DC54570B3E9FF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021170 Genomic DNA. Translation: BAA35192.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB021170 Genomic DNA. Translation: BAA35192.1 .

3D structure databases

ProteinModelPortali O93829.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG5536.

Family and domain databases

InterProi IPR002088. Prenyl_trans_a.
[Graphical view ]
Pfami PF01239. PPTA. 4 hits.
[Graphical view ]
PROSITEi PS51147. PFTA. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of BET4 gene from Candida albicans."
    Ishii N., Aoki Y., Arisawa M.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Entry informationi

Entry nameiPGTA_CANAX
AccessioniPrimary (citable) accession number: O93829
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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