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O93829 (PGTA_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Geranylgeranyl transferase type-2 subunit alpha

EC=2.5.1.60
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
YPT1/SEC4 proteins geranylgeranyltransferase subunit alpha
Gene names
Name:BET4
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length371 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal -XCC or -XCXC, where both cysteines may become modified. Acts on YPT1 and SEC4 By similarity.

Catalytic activity

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

Subunit structure

Heterodimer of an alpha and a beta subunit By similarity.

Sequence similarities

Belongs to the protein prenyltransferase subunit alpha family.

Contains 5 PFTA repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 371371Geranylgeranyl transferase type-2 subunit alpha
PRO_0000119755

Regions

Repeat45 – 7935PFTA 1
Repeat92 – 12635PFTA 2
Repeat131 – 16535PFTA 3
Repeat177 – 21135PFTA 4
Repeat242 – 27635PFTA 5
Compositional bias214 – 2218Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
O93829 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 69DC54570B3E9FF0

FASTA37144,462
        10         20         30         40         50         60 
MQHGIKRVKL SEEAKRLKLE KDQIKIKNYR QLTDEIFELR ANENYSDEAL IKTNELLIIN 

        70         80         90        100        110        120 
PEFYTIWNYR REILINNYSS SNDKDDQIYE DILNQDLNFV LVQLKKFPKC YWIWNHRRWL 

       130        140        150        160        170        180 
LFELVKLGKV NWKYEFGVVS KLLDLDQRNF HGWHYRRFVV KNMELECKND TTLILKINLD 

       190        200        210        220        230        240 
EFNYTTLKIQ KDFSNFSAWH NRTKLIPKIY NLIQQQQQQQ QKDGKIFGDL PGIELFQNPI 

       250        260        270        280        290        300 
LLLKNDLEMI KTGVYMSPED TSVWLYLYWL LTDDLFTNAF KSHQQDYMNI LHEQLQLINE 

       310        320        330        340        350        360 
VNEMEKEDTG QDNVGCLKSM IFINALIQNE NNKPVLTEQV KSCLKQLAKI DPLRKNKYLD 

       370 
QLAGNAPIFH H 

« Hide

References

[1]"Molecular cloning of BET4 gene from Candida albicans."
Ishii N., Aoki Y., Arisawa M.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB021170 Genomic DNA. Translation: BAA35192.1.

3D structure databases

ProteinModelPortalO93829.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG5536.

Family and domain databases

InterProIPR002088. Prenyl_trans_a.
[Graphical view]
PfamPF01239. PPTA. 4 hits.
[Graphical view]
PROSITEPS51147. PFTA. 5 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGTA_CANAX
AccessionPrimary (citable) accession number: O93829
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 1, 1999
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families