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Protein

Mannose-1-phosphate guanyltransferase

Gene

MPG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).By similarity

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.1 Publication

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase (MPG1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • mannose-1-phosphate guanylyltransferase activity Source: CGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell wall mannoprotein biosynthetic process Source: CGD
  • GDP-mannose biosynthetic process Source: CGD

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processCell cycle
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.13 1096
UniPathwayiUPA00126; UER00930

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
Alternative name(s):
ATP-mannose-1-phosphate guanylyltransferase
CASRB1
GDP-mannose pyrophosphorylase
Gene namesi
Name:MPG1
Synonyms:SRB1, VIG9
Ordered Locus Names:CAALFM_C307950CA
ORF Names:CaO19.6190
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000178573 SRB1
EuPathDBiFungiDB:C3_07950C_A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000687391 – 362Mannose-1-phosphate guanyltransferaseAdd BLAST362

Proteomic databases

PRIDEiO93827

2D gel databases

COMPLUYEAST-2DPAGEiO93827

Structurei

3D structure databases

ProteinModelPortaliO93827
SMRiO93827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiO93827
KOiK00966
OMAiYWMDVGQ
OrthoDBiEOG092C3YQK

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR005835 NTP_transferase_dom
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF00132 Hexapep, 1 hit
PF00483 NTP_transferase, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

O93827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLILVGGY GTRLRPLTLT LPKPLVEFGN RPMILHQIEA LAAAGVTDIV
60 70 80 90 100
LAVNYRPEVM VSTLKKYEEE YGVSITFSVE EEPLGTAGPL KLAEEVLKKD
110 120 130 140 150
DSPFFVLNSD VICDYPFKEL ADFHKAHGAA GTIVATKVDE PSKYGVIVHD
160 170 180 190 200
RDTPNLIDRF VEKPVEFVGN RINAGLYILN PSVIDLIEMR PTSIEKETFP
210 220 230 240 250
ILVEQKQLYS FDLEGYWMDV GQPKDFLSGT CLYLTSLSKK HPEKLCKEKY
260 270 280 290 300
VHGGNVLIDP TAKIHPSALI GPNVTIGPNV VVGEGARIQR SVLLANSQVK
310 320 330 340 350
DHAWVKSTIV GWNSRIGKWA RTEGVTVLGD DVEVKNEIYV NGAKVLPHKS
360
ISSNVEKESI IM
Length:362
Mass (Da):39,975
Last modified:May 1, 1999 - v1
Checksum:i052DCC32D0E16923
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Q → R in AAC64912 (PubMed:9782489).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti197 – 198ET → DP in strain: 1161. 2
Natural varianti333E → Q in strain: 1161. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030299 Genomic DNA Translation: AAC64911.1
AF030300 Genomic DNA Translation: AAC64912.1
AB020596 Genomic DNA Translation: BAA34807.1
CP017625 Genomic DNA Translation: AOW28792.1
RefSeqiXP_710946.1, XM_705854.1

Genome annotation databases

EnsemblFungiiAOW28792; AOW28792; CAALFM_C307950CA
GeneIDi3647454
KEGGical:CAALFM_C307950CA

Similar proteinsi

Entry informationi

Entry nameiMPG1_CANAL
AccessioniPrimary (citable) accession number: O93827
Secondary accession number(s): A0A1D8PKY0, Q59MI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health