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Protein

Mannose-1-phosphate guanyltransferase

Gene

MPG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).By similarity

Catalytic activityi

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.1 Publication

Pathway: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route).
Proteins known to be involved in this subpathway in this organism are:
  1. Mannose-1-phosphate guanyltransferase (MPG1)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route), the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • mannose-1-phosphate guanylyltransferase activity Source: CGD

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell wall mannoprotein biosynthetic process Source: CGD
  • GDP-mannose biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.7.13. 1096.
UniPathwayiUPA00126; UER00930.

Names & Taxonomyi

Protein namesi
Recommended name:
Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
Alternative name(s):
ATP-mannose-1-phosphate guanylyltransferase
CASRB1
GDP-mannose pyrophosphorylase
Gene namesi
Name:MPG1
Synonyms:SRB1, VIG9
ORF Names:CaO19.6190
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0006140. SRB1.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: CGD
  • cytoplasm Source: UniProtKB-SubCell
  • plasma membrane Source: CGD
  • yeast-form cell wall Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Mannose-1-phosphate guanyltransferasePRO_0000068739Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEO93827.

Structurei

3D structure databases

ProteinModelPortaliO93827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1208.
InParanoidiO93827.
KOiK00966.
OrthoDBiEOG7712HW.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep_transf.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

O93827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLILVGGY GTRLRPLTLT LPKPLVEFGN RPMILHQIEA LAAAGVTDIV
60 70 80 90 100
LAVNYRPEVM VSTLKKYEEE YGVSITFSVE EEPLGTAGPL KLAEEVLKKD
110 120 130 140 150
DSPFFVLNSD VICDYPFKEL ADFHKAHGAA GTIVATKVDE PSKYGVIVHD
160 170 180 190 200
RDTPNLIDRF VEKPVEFVGN RINAGLYILN PSVIDLIEMR PTSIEKETFP
210 220 230 240 250
ILVEQKQLYS FDLEGYWMDV GQPKDFLSGT CLYLTSLSKK HPEKLCKEKY
260 270 280 290 300
VHGGNVLIDP TAKIHPSALI GPNVTIGPNV VVGEGARIQR SVLLANSQVK
310 320 330 340 350
DHAWVKSTIV GWNSRIGKWA RTEGVTVLGD DVEVKNEIYV NGAKVLPHKS
360
ISSNVEKESI IM
Length:362
Mass (Da):39,975
Last modified:May 1, 1999 - v1
Checksum:i052DCC32D0E16923
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti289 – 2891Q → R in AAC64912 (PubMed:9782489).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti197 – 1982ET → DP in strain: 1161.
Natural varianti333 – 3331E → Q in strain: 1161.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030299 Genomic DNA. Translation: AAC64911.1.
AF030300 Genomic DNA. Translation: AAC64912.1.
AB020596 Genomic DNA. Translation: BAA34807.1.
AACQ01000225 Genomic DNA. Translation: EAK91704.1.
RefSeqiXP_710946.1. XM_705854.1.

Genome annotation databases

GeneIDi3647454.
KEGGical:CaO19.6190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030299 Genomic DNA. Translation: AAC64911.1.
AF030300 Genomic DNA. Translation: AAC64912.1.
AB020596 Genomic DNA. Translation: BAA34807.1.
AACQ01000225 Genomic DNA. Translation: EAK91704.1.
RefSeqiXP_710946.1. XM_705854.1.

3D structure databases

ProteinModelPortaliO93827.
ModBaseiSearch...
MobiDBiSearch...

2D gel databases

COMPLUYEAST-2DPAGEO93827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3647454.
KEGGical:CaO19.6190.

Organism-specific databases

CGDiCAL0006140. SRB1.

Phylogenomic databases

eggNOGiCOG1208.
InParanoidiO93827.
KOiK00966.
OrthoDBiEOG7712HW.

Enzyme and pathway databases

UniPathwayiUPA00126; UER00930.
BRENDAi2.7.7.13. 1096.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001451. Hexapep_transf.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of the Candida albicans homologue of SRB1/PSA1/VIG9, the essential gene encoding GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae."
    Warit S., Walmsley R.M., Stateva L.I.
    Microbiology 144:2417-2426(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1161.
  2. "The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase."
    Ohta A., Chibana H., Arisawa M., Sudoh M.
    Biochim. Biophys. Acta 1475:265-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
    Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiMPG1_CANAL
AccessioniPrimary (citable) accession number: O93827
Secondary accession number(s): Q59MI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: June 24, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.