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O93827

- MPG1_CANAL

UniProt

O93827 - MPG1_CANAL

Protein

Mannose-1-phosphate guanyltransferase

Gene

MPG1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.By similarity

    Catalytic activityi

    GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.1 Publication

    Pathwayi

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. mannose-1-phosphate guanylyltransferase activity Source: CGD

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell wall mannoprotein biosynthetic process Source: CGD
    3. GDP-mannose biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Cell cycle

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.7.13. 1096.
    UniPathwayiUPA00126; UER00930.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannose-1-phosphate guanyltransferase (EC:2.7.7.13)
    Alternative name(s):
    ATP-mannose-1-phosphate guanylyltransferase
    CASRB1
    GDP-mannose pyrophosphorylase
    Gene namesi
    Name:MPG1
    Synonyms:SRB1, VIG9
    ORF Names:CaO19.6190
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0006140. SRB1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cell surface Source: CGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. plasma membrane Source: CGD
    4. yeast-form cell wall Source: CGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 362362Mannose-1-phosphate guanyltransferasePRO_0000068739Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEO93827.

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0006140.

    Structurei

    3D structure databases

    ProteinModelPortaliO93827.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1208.
    KOiK00966.
    OrthoDBiEOG7712HW.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR001451. Hexapep_transf.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    O93827-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGLILVGGY GTRLRPLTLT LPKPLVEFGN RPMILHQIEA LAAAGVTDIV    50
    LAVNYRPEVM VSTLKKYEEE YGVSITFSVE EEPLGTAGPL KLAEEVLKKD 100
    DSPFFVLNSD VICDYPFKEL ADFHKAHGAA GTIVATKVDE PSKYGVIVHD 150
    RDTPNLIDRF VEKPVEFVGN RINAGLYILN PSVIDLIEMR PTSIEKETFP 200
    ILVEQKQLYS FDLEGYWMDV GQPKDFLSGT CLYLTSLSKK HPEKLCKEKY 250
    VHGGNVLIDP TAKIHPSALI GPNVTIGPNV VVGEGARIQR SVLLANSQVK 300
    DHAWVKSTIV GWNSRIGKWA RTEGVTVLGD DVEVKNEIYV NGAKVLPHKS 350
    ISSNVEKESI IM 362
    Length:362
    Mass (Da):39,975
    Last modified:May 1, 1999 - v1
    Checksum:i052DCC32D0E16923
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti289 – 2891Q → R in AAC64912. (PubMed:9782489)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti197 – 1982ET → DP in strain: 1161.
    Natural varianti333 – 3331E → Q in strain: 1161.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030299 Genomic DNA. Translation: AAC64911.1.
    AF030300 Genomic DNA. Translation: AAC64912.1.
    AB020596 Genomic DNA. Translation: BAA34807.1.
    AACQ01000225 Genomic DNA. Translation: EAK91704.1.
    RefSeqiXP_710946.1. XM_705854.1.

    Genome annotation databases

    GeneIDi3647454.
    KEGGical:CaO19.6190.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF030299 Genomic DNA. Translation: AAC64911.1 .
    AF030300 Genomic DNA. Translation: AAC64912.1 .
    AB020596 Genomic DNA. Translation: BAA34807.1 .
    AACQ01000225 Genomic DNA. Translation: EAK91704.1 .
    RefSeqi XP_710946.1. XM_705854.1.

    3D structure databases

    ProteinModelPortali O93827.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0006140.

    2D gel databases

    COMPLUYEAST-2DPAGE O93827.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3647454.
    KEGGi cal:CaO19.6190.

    Organism-specific databases

    CGDi CAL0006140. SRB1.

    Phylogenomic databases

    eggNOGi COG1208.
    KOi K00966.
    OrthoDBi EOG7712HW.

    Enzyme and pathway databases

    UniPathwayi UPA00126 ; UER00930 .
    BRENDAi 2.7.7.13. 1096.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR001451. Hexapep_transf.
    IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00132. Hexapep. 1 hit.
    PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of the Candida albicans homologue of SRB1/PSA1/VIG9, the essential gene encoding GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae."
      Warit S., Walmsley R.M., Stateva L.I.
      Microbiology 144:2417-2426(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1161.
    2. "The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase."
      Ohta A., Chibana H., Arisawa M., Sudoh M.
      Biochim. Biophys. Acta 1475:265-272(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
      Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiMPG1_CANAL
    AccessioniPrimary (citable) accession number: O93827
    Secondary accession number(s): Q59MI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3