Reviewed,
UniProtKB/Swiss-Prot O93827 (MPG1_CANAL)
Last modified
November 3, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mannose-1-phosphate guanyltransferase EC=2.7.7.13 Alternative name(s): ATP-mannose-1-phosphate guanylyltransferase GDP-mannose pyrophosphorylase CASRB1 | ||||||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||||||
| Taxonomic identifier | 5476 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 362 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity. |
| Catalytic activity | GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. Ref.2 |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the transferase hexapeptide repeat family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Cell cycle |
| Cellular component | Cytoplasm |
| Ligand | GTP-binding Nucleotide-binding |
| Molecular function | Nucleotidyltransferase Transferase |
| Gene Ontology (GO) | |
| Biological process | biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycleInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 362 | 362 | Mannose-1-phosphate guanyltransferase | PRO_0000068739 | |||||
Natural variations | |||||||||
| Natural variant | 197 – 198 | 2 | ET → DP in strain: 1161. | ||||||
| Natural variant | 333 | 1 | E → Q in strain: 1161. | ||||||
Experimental info | |||||||||
| Sequence conflict | 289 | 1 | Q → R in AAC64912. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning and sequencing of the Candida albicans homologue of SRB1/PSA1/VIG9, the essential gene encoding GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae." Warit S., Walmsley R.M., Stateva L.I. Microbiology 144:2417-2426(1998) [PubMed: 9782489] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 1161. |
| [2] | "The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase." Ohta A., Chibana H., Arisawa M., Sudoh M. Biochim. Biophys. Acta 1475:265-272(2000) [PubMed: 10913825] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY. Strain: ATCC 10259 / CBS 5796 / IFO 1060 / JCM 2078. |
| [3] | "The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314. |
Cross-references
Sequence databases | |
|---|---|
| AF030299 Genomic DNA. Translation: AAC64911.1. AF030300 Genomic DNA. Translation: AAC64912.1. AB020596 Genomic DNA. Translation: BAA34807.1. AACQ01000225 Genomic DNA. Translation: EAK91704.1. | |
| RefSeq | XP_710946.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HM0 based on UniProtKB Q97R46. |
| ModBase | Search... |
2-D gel databases | |
| COMPLUYEAST-2DPAGE | O93827. |
Genome annotation databases | |
| GeneID | 3647454. |
| KEGG | cal:CaO19.6190. |
Organism-specific databases | |
| CGD | CAL0006140. SRB1. |
Phylogenomic databases | |
| OMA | LVFNADI. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.13. 1124. |
Family and domain databases | |
| InterPro | IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view] |
| Pfam | PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view] |
| PROSITE | PS00101. HEXAPEP_TRANSFERASES. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MPG1_CANAL | ||||||||
| Accession | Primary (citable) accession number: O93827 Secondary accession number(s): Q59MI2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


