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O93827 (MPG1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannose-1-phosphate guanyltransferase

EC=2.7.7.13
Alternative name(s):
ATP-mannose-1-phosphate guanylyltransferase
CASRB1
GDP-mannose pyrophosphorylase
Gene names
Name:MPG1
Synonyms:SRB1, VIG9
ORF Names:CaO19.6190
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.

Catalytic activity

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose. Ref.2

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Mannose-1-phosphate guanyltransferase
PRO_0000068739

Natural variations

Natural variant197 – 1982ET → DP in strain: 1161.
Natural variant3331E → Q in strain: 1161.

Experimental info

Sequence conflict2891Q → R in AAC64912. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O93827 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 052DCC32D0E16923

FASTA36239,975
        10         20         30         40         50         60 
MKGLILVGGY GTRLRPLTLT LPKPLVEFGN RPMILHQIEA LAAAGVTDIV LAVNYRPEVM 

        70         80         90        100        110        120 
VSTLKKYEEE YGVSITFSVE EEPLGTAGPL KLAEEVLKKD DSPFFVLNSD VICDYPFKEL 

       130        140        150        160        170        180 
ADFHKAHGAA GTIVATKVDE PSKYGVIVHD RDTPNLIDRF VEKPVEFVGN RINAGLYILN 

       190        200        210        220        230        240 
PSVIDLIEMR PTSIEKETFP ILVEQKQLYS FDLEGYWMDV GQPKDFLSGT CLYLTSLSKK 

       250        260        270        280        290        300 
HPEKLCKEKY VHGGNVLIDP TAKIHPSALI GPNVTIGPNV VVGEGARIQR SVLLANSQVK 

       310        320        330        340        350        360 
DHAWVKSTIV GWNSRIGKWA RTEGVTVLGD DVEVKNEIYV NGAKVLPHKS ISSNVEKESI 


IM 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of the Candida albicans homologue of SRB1/PSA1/VIG9, the essential gene encoding GDP-mannose pyrophosphorylase in Saccharomyces cerevisiae."
Warit S., Walmsley R.M., Stateva L.I.
Microbiology 144:2417-2426(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1161.
[2]"The VIG9 gene products from the human pathogenic fungi Candida albicans and Candida glabrata encode GDP-mannose pyrophosphorylase."
Ohta A., Chibana H., Arisawa M., Sudoh M.
Biochim. Biophys. Acta 1475:265-272(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], CATALYTIC ACTIVITY.
Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
[3]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF030299 Genomic DNA. Translation: AAC64911.1.
AF030300 Genomic DNA. Translation: AAC64912.1.
AB020596 Genomic DNA. Translation: BAA34807.1.
AACQ01000225 Genomic DNA. Translation: EAK91704.1.
RefSeqXP_710946.1. XM_705854.1.

3D structure databases

ProteinModelPortalO93827.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0006140.

2D gel databases

COMPLUYEAST-2DPAGEO93827.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3647454.
KEGGcal:CaO19.6190.

Organism-specific databases

CGDCAL0006140. SRB1.

Phylogenomic databases

eggNOGCOG1208.
KOK00966.
OrthoDBEOG7712HW.

Enzyme and pathway databases

BRENDA2.7.7.13. 1096.
UniPathwayUPA00126; UER00930.

Family and domain databases

Gene3D3.90.550.10. 1 hit.
InterProIPR001451. Hexapep_transf.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamPF00132. Hexapep. 1 hit.
PF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMPG1_CANAL
AccessionPrimary (citable) accession number: O93827
Secondary accession number(s): Q59MI2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names