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Protein

Tubulin gamma chain

Gene

TUB4

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi169 – 175GTPSequence analysis7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma chain
Alternative name(s):
Gamma-tubulin
Gene namesi
Name:TUB4
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000484491 – 502Tubulin gamma chainAdd BLAST502

Structurei

3D structure databases

ProteinModelPortaliO93807.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi471 – 477Poly-Asp7
Compositional biasi481 – 491Poly-GlyAdd BLAST11

Sequence similaritiesi

Belongs to the tubulin family.Curated

Family and domain databases

CDDicd02188. gamma_tubulin. 1 hit.
Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 2 hits.
PTHR11588:SF7. PTHR11588:SF7. 2 hits.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93807-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGETITLQV GQCGNQVGLQ YWQQLATEHG IQSDGSSTPY PKDINDLQLQ
60 70 80 90 100
ELNNSGSSPQ SYPQQTKPNG KYRNDHPELF FTLSDSNTYT PRSILIDMEP
110 120 130 140 150
SVIAKSTSAL PMFNPRNVHL SNQGNGAANN WINGYKYGTE EEETLLNLID
160 170 180 190 200
REVDKCDNLS NFQLFHSVAG GTGSGVGSKM LEVISDRYGH KKLLNTFSIF
210 220 230 240 250
PSNEDTSDVV VQPYNTILTL KRLIDYSDAT FVFHNDSLNR IENILFNNNS
260 270 280 290 300
NIQHDDNDLF LGANKLIALV SASVSNPLRF PGYMYSSMES IVSNLIPTPD
310 320 330 340 350
LKFLTSSIAP FSTQKHNYLN EYDMLLELSN DRYKTNRVGG DTSYISMLNY
360 370 380 390 400
LIGYNLDQRE IRKGILKSQQ RISFVPWVAR SVLVVHGKKS PYLKNTNLEG
410 420 430 440 450
IQVTNNTSMI DVFTKILKQF DLLIKRKAYL NRYYSSVEEE NEVMEMFNES
460 470 480 490 500
RESVKSIIDE YKACKEITYL DDDDEDDLED GDGGGGGNGN GYNNIDDADM

GI
Length:502
Mass (Da):56,481
Last modified:May 1, 1999 - v1
Checksum:i5B9E499258CA4BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017784 Genomic DNA. Translation: BAA74797.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017784 Genomic DNA. Translation: BAA74797.1.

3D structure databases

ProteinModelPortaliO93807.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd02188. gamma_tubulin. 1 hit.
Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 2 hits.
PTHR11588:SF7. PTHR11588:SF7. 2 hits.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 2 hits.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBG_CANAX
AccessioniPrimary (citable) accession number: O93807
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: October 5, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.