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O93795

- PLB2_CANAX

UniProt

O93795 - PLB2_CANAX

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Protein
Lysophospholipase 2
Gene
PLB2
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
CaPLB2
Phospholipase B 2
Gene namesi
Name:PLB2
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

Secreted Inferred

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717 Reviewed prediction
Add
BLAST
Chaini18 – 608591Lysophospholipase 2
PRO_0000024631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi365 – 3651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi450 – 4501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi464 – 4641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi491 – 4911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi572 – 5721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO93795.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 564535PLA2c
Add
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.
Contains 1 PLA2c domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1325.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93795-1 [UniParc]FASTAAdd to Basket

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MLVWQSILLF LVGCVLSKSP TNLYTPGYVQ CPEGKLTRSS LDGINSNEKA    50
YIDRRYANAK SELSRFLHNA KMVDFDVDGF LNSNPTIGLA FSGGGYRAML 100
AGAGELLALD SRATNPSVLS GILQSSSYIV GLSGGSWLVG SLASNDLIPV 150
DQLLREDKLW DIQNSLVAYY GVNIVRNTAM WGNINLQVQT KQLAGFTVSI 200
TDVYGRALSH QLLTNFDNQG ASFLWSDVTE TTSFQNNEMP YPILAALGRE 250
PNTVLMNFNS TVFELTPYEV GSWDPSLRSF VDTKYIGTRL DDGAPVSKRC 300
VNGFDNAGFF MGTSSSLFNI VLQQLNNMPI PPFLKELISK FTLDPVEKLN 350
IDIAQYNPNP FHKSNNSDTK IAQSRTLYLA DGGEDGQNVP LLPLIHRKVS 400
AIFAFDQSAD KNNWPDGSAL IKTFERQFSS QGDGIAFPYV PDQNTFRNTN 450
LTSKPTFFGC DAQNLTSLTE NIYDVPVVIY LANRPFTYFS NISTFKLKYS 500
DTERQGMISN GYDVASRLNG KLDNEWAACV GCAIIRREQE RLGIEQTEQC 550
KKCFENYCWD GTIYKGEPLG DNFSDEGLTT SAAYYNSNNV AGINDGGIAL 600
VKRDDLSN 608
Length:608
Mass (Da):67,220
Last modified:May 1, 1999 - v1
Checksum:i0ABEA2C878CD8610
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010809 Genomic DNA. Translation: BAA36162.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010809 Genomic DNA. Translation: BAA36162.1 .

3D structure databases

ProteinModelPortali O93795.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi KOG1325.

Family and domain databases

InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view ]
Pfami PF01735. PLA2_B. 1 hit.
[Graphical view ]
SMARTi SM00022. PLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF52151. SSF52151. 1 hit.
PROSITEi PS51210. PLA2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans."
    Sugiyama Y., Nakashima S., Mirbod F., Kanoh H., Kitajima Y., Ghannoum M.A., Nozawa Y.
    Med. Mycol. 37:61-67(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPLB2_CANAX
AccessioniPrimary (citable) accession number: O93795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1999
Last modified: June 11, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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