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O93795

- PLB2_CANAX

UniProt

O93795 - PLB2_CANAX

Protein

Lysophospholipase 2

Gene

PLB2

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 May 1999)
      Previous versions | rss
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    Functioni

    Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. phospholipid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase 2 (EC:3.1.1.5)
    Alternative name(s):
    CaPLB2
    Phospholipase B 2
    Gene namesi
    Name:PLB2
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 608591Lysophospholipase 2PRO_0000024631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliO93795.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 564535PLA2cPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the lysophospholipase family.Curated
    Contains 1 PLA2c domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiKOG1325.

    Family and domain databases

    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view]
    PfamiPF01735. PLA2_B. 1 hit.
    [Graphical view]
    SMARTiSM00022. PLAc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52151. SSF52151. 1 hit.
    PROSITEiPS51210. PLA2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O93795-1 [UniParc]FASTAAdd to Basket

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    MLVWQSILLF LVGCVLSKSP TNLYTPGYVQ CPEGKLTRSS LDGINSNEKA    50
    YIDRRYANAK SELSRFLHNA KMVDFDVDGF LNSNPTIGLA FSGGGYRAML 100
    AGAGELLALD SRATNPSVLS GILQSSSYIV GLSGGSWLVG SLASNDLIPV 150
    DQLLREDKLW DIQNSLVAYY GVNIVRNTAM WGNINLQVQT KQLAGFTVSI 200
    TDVYGRALSH QLLTNFDNQG ASFLWSDVTE TTSFQNNEMP YPILAALGRE 250
    PNTVLMNFNS TVFELTPYEV GSWDPSLRSF VDTKYIGTRL DDGAPVSKRC 300
    VNGFDNAGFF MGTSSSLFNI VLQQLNNMPI PPFLKELISK FTLDPVEKLN 350
    IDIAQYNPNP FHKSNNSDTK IAQSRTLYLA DGGEDGQNVP LLPLIHRKVS 400
    AIFAFDQSAD KNNWPDGSAL IKTFERQFSS QGDGIAFPYV PDQNTFRNTN 450
    LTSKPTFFGC DAQNLTSLTE NIYDVPVVIY LANRPFTYFS NISTFKLKYS 500
    DTERQGMISN GYDVASRLNG KLDNEWAACV GCAIIRREQE RLGIEQTEQC 550
    KKCFENYCWD GTIYKGEPLG DNFSDEGLTT SAAYYNSNNV AGINDGGIAL 600
    VKRDDLSN 608
    Length:608
    Mass (Da):67,220
    Last modified:May 1, 1999 - v1
    Checksum:i0ABEA2C878CD8610
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010809 Genomic DNA. Translation: BAA36162.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB010809 Genomic DNA. Translation: BAA36162.1 .

    3D structure databases

    ProteinModelPortali O93795.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi KOG1325.

    Family and domain databases

    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR002642. LysoPLipase_cat_dom.
    [Graphical view ]
    Pfami PF01735. PLA2_B. 1 hit.
    [Graphical view ]
    SMARTi SM00022. PLAc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52151. SSF52151. 1 hit.
    PROSITEi PS51210. PLA2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans."
      Sugiyama Y., Nakashima S., Mirbod F., Kanoh H., Kitajima Y., Ghannoum M.A., Nozawa Y.
      Med. Mycol. 37:61-67(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPLB2_CANAX
    AccessioniPrimary (citable) accession number: O93795
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: May 1, 1999
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3