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O93795 (PLB2_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase 2

EC=3.1.1.5
Alternative name(s):
CaPLB2
Phospholipase B 2
Gene names
Name:PLB2
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length608 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Subcellular location

Secreted Probable.

Sequence similarities

Belongs to the lysophospholipase family.

Contains 1 PLA2c domain.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentSecreted
   DomainSignal
   Molecular functionHydrolase
   PTMGlycoprotein
Gene Ontology (GO)
   Biological_processphospholipid catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionlysophospholipase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 608591Lysophospholipase 2
PRO_0000024631

Regions

Domain30 – 564535PLA2c

Amino acid modifications

Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation3651N-linked (GlcNAc...) Potential
Glycosylation4501N-linked (GlcNAc...) Potential
Glycosylation4641N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Glycosylation5721N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O93795 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: 0ABEA2C878CD8610

FASTA60867,220
        10         20         30         40         50         60 
MLVWQSILLF LVGCVLSKSP TNLYTPGYVQ CPEGKLTRSS LDGINSNEKA YIDRRYANAK 

        70         80         90        100        110        120 
SELSRFLHNA KMVDFDVDGF LNSNPTIGLA FSGGGYRAML AGAGELLALD SRATNPSVLS 

       130        140        150        160        170        180 
GILQSSSYIV GLSGGSWLVG SLASNDLIPV DQLLREDKLW DIQNSLVAYY GVNIVRNTAM 

       190        200        210        220        230        240 
WGNINLQVQT KQLAGFTVSI TDVYGRALSH QLLTNFDNQG ASFLWSDVTE TTSFQNNEMP 

       250        260        270        280        290        300 
YPILAALGRE PNTVLMNFNS TVFELTPYEV GSWDPSLRSF VDTKYIGTRL DDGAPVSKRC 

       310        320        330        340        350        360 
VNGFDNAGFF MGTSSSLFNI VLQQLNNMPI PPFLKELISK FTLDPVEKLN IDIAQYNPNP 

       370        380        390        400        410        420 
FHKSNNSDTK IAQSRTLYLA DGGEDGQNVP LLPLIHRKVS AIFAFDQSAD KNNWPDGSAL 

       430        440        450        460        470        480 
IKTFERQFSS QGDGIAFPYV PDQNTFRNTN LTSKPTFFGC DAQNLTSLTE NIYDVPVVIY 

       490        500        510        520        530        540 
LANRPFTYFS NISTFKLKYS DTERQGMISN GYDVASRLNG KLDNEWAACV GCAIIRREQE 

       550        560        570        580        590        600 
RLGIEQTEQC KKCFENYCWD GTIYKGEPLG DNFSDEGLTT SAAYYNSNNV AGINDGGIAL 


VKRDDLSN 

« Hide

References

[1]"Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans."
Sugiyama Y., Nakashima S., Mirbod F., Kanoh H., Kitajima Y., Ghannoum M.A., Nozawa Y.
Med. Mycol. 37:61-67(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB010809 Genomic DNA. Translation: BAA36162.1.

3D structure databases

ProteinModelPortalO93795.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGKOG1325.

Family and domain databases

InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMSSF52151. SSF52151. 1 hit.
PROSITEPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePLB2_CANAX
AccessionPrimary (citable) accession number: O93795
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1999
Last modified: October 16, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families