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Protein

Lysophospholipase 2

Gene

PLB2

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the release of fatty acids from lysophospholipids. Phospholipase B may well contribute to pathogenicity by abetting the fungus in damaging and traversing host cell membranes, processes which likely increase the rapidity of disseminated infection.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. phospholipid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase 2 (EC:3.1.1.5)
Alternative name(s):
CaPLB2
Phospholipase B 2
Gene namesi
Name:PLB2
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 608591Lysophospholipase 2PRO_0000024631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi464 – 4641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi491 – 4911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliO93795.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 564535PLA2cPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the lysophospholipase family.Curated
Contains 1 PLA2c domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1325.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVWQSILLF LVGCVLSKSP TNLYTPGYVQ CPEGKLTRSS LDGINSNEKA
60 70 80 90 100
YIDRRYANAK SELSRFLHNA KMVDFDVDGF LNSNPTIGLA FSGGGYRAML
110 120 130 140 150
AGAGELLALD SRATNPSVLS GILQSSSYIV GLSGGSWLVG SLASNDLIPV
160 170 180 190 200
DQLLREDKLW DIQNSLVAYY GVNIVRNTAM WGNINLQVQT KQLAGFTVSI
210 220 230 240 250
TDVYGRALSH QLLTNFDNQG ASFLWSDVTE TTSFQNNEMP YPILAALGRE
260 270 280 290 300
PNTVLMNFNS TVFELTPYEV GSWDPSLRSF VDTKYIGTRL DDGAPVSKRC
310 320 330 340 350
VNGFDNAGFF MGTSSSLFNI VLQQLNNMPI PPFLKELISK FTLDPVEKLN
360 370 380 390 400
IDIAQYNPNP FHKSNNSDTK IAQSRTLYLA DGGEDGQNVP LLPLIHRKVS
410 420 430 440 450
AIFAFDQSAD KNNWPDGSAL IKTFERQFSS QGDGIAFPYV PDQNTFRNTN
460 470 480 490 500
LTSKPTFFGC DAQNLTSLTE NIYDVPVVIY LANRPFTYFS NISTFKLKYS
510 520 530 540 550
DTERQGMISN GYDVASRLNG KLDNEWAACV GCAIIRREQE RLGIEQTEQC
560 570 580 590 600
KKCFENYCWD GTIYKGEPLG DNFSDEGLTT SAAYYNSNNV AGINDGGIAL

VKRDDLSN
Length:608
Mass (Da):67,220
Last modified:May 1, 1999 - v1
Checksum:i0ABEA2C878CD8610
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010809 Genomic DNA. Translation: BAA36162.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB010809 Genomic DNA. Translation: BAA36162.1.

3D structure databases

ProteinModelPortaliO93795.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG1325.

Family and domain databases

InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR002642. LysoPLipase_cat_dom.
[Graphical view]
PfamiPF01735. PLA2_B. 1 hit.
[Graphical view]
SMARTiSM00022. PLAc. 1 hit.
[Graphical view]
SUPFAMiSSF52151. SSF52151. 1 hit.
PROSITEiPS51210. PLA2C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a second phospholipase B gene, caPLB2 from Candida albicans."
    Sugiyama Y., Nakashima S., Mirbod F., Kanoh H., Kitajima Y., Ghannoum M.A., Nozawa Y.
    Med. Mycol. 37:61-67(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPLB2_CANAX
AccessioniPrimary (citable) accession number: O93795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 1, 1999
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.