ID   O93785_HYPJE            Unreviewed;       466 AA.
AC   O93785;
DT   01-MAY-1999, integrated into UniProtKB/TrEMBL.
DT   01-MAY-1999, sequence version 1.
DT   27-MAR-2024, entry version 115.
DE   SubName: Full=Beta-glucosidase {ECO:0000313|EMBL:BAA74959.1};
GN   Name=bgl2 {ECO:0000313|EMBL:BAA74959.1};
OS   Hypocrea jecorina (Trichoderma reesei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=51453 {ECO:0000313|EMBL:BAA74959.1};
RN   [1] {ECO:0000313|EMBL:BAA74959.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=QM9414 {ECO:0000313|EMBL:BAA74959.1};
RX   PubMed=10101286; DOI=10.1093/oxfordjournals.jbchem.a022343;
RA   Takashima S., Nakamura A., Hidaka M., Masaki H., Uozumi T.;
RT   "Molecular cloning and expression of the novel fungal beta-glucosidase
RT   genes from Humicola grisea and Trichoderma reesei.";
RL   J. Biochem. 125:728-736(1999).
RN   [2] {ECO:0007829|PDB:3AHY}
RP   X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS).
RX   PubMed=20682343; DOI=10.1016/j.jsb.2010.07.008;
RA   Jeng W.Y., Wang N.C., Lin M.H., Lin C.T., Liaw Y.C., Chang W.J., Liu C.I.,
RA   Liang P.H., Wang A.H.;
RT   "Structural and functional analysis of three beta-glucosidases from
RT   bacterium Clostridium cellulovorans, fungus Trichoderma reesei and termite
RT   Neotermes koshunensis.";
RL   J. Struct. Biol. 173:46-56(2011).
RN   [3] {ECO:0007829|PDB:4GXP}
RP   X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 160-202; 221-367 AND 399-413.
RX   PubMed=23225662; DOI=10.1002/pro.2202;
RA   Smith M.A., Romero P.A., Wu T., Brustad E.M., Arnold F.H.;
RT   "Chimeragenesis of distantly-related proteins by noncontiguous
RT   recombination.";
RL   Protein Sci. 22:231-238(2013).
RN   [4] {ECO:0000313|EMBL:AHK23047.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SJVTR {ECO:0000313|EMBL:AHK23047.1};
RA   Venkatesh S.S., John Vennison S.S., Immanual Gilwax Prabhu D.;
RT   "Cellulose degradation by Trichoderma reesei beta-glucosidase.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family.
CC       {ECO:0000256|RuleBase:RU003690}.
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DR   EMBL; KF979307; AHK23047.1; -; mRNA.
DR   EMBL; AB003110; BAA74959.1; -; Genomic_DNA.
DR   PDB; 3AHY; X-ray; 1.63 A; A/B/C/D=1-466.
DR   PDB; 4GXP; X-ray; 3.00 A; A/B/C=118-123, A/B/C=133-138, A/B/C=163-205, A/B/C=224-335, A/B/C=338-369, A/B/C=396-397, A/B/C=399-415.
DR   PDBsum; 3AHY; -.
DR   PDBsum; 4GXP; -.
DR   AlphaFoldDB; O93785; -.
DR   SMR; O93785; -.
DR   CAZy; GH1; Glycoside Hydrolase Family 1.
DR   CLAE; BGL1B_TRIRE; -.
DR   VEuPathDB; FungiDB:TrQ_001288; -.
DR   OMA; HGSNDFY; -.
DR   BioCyc; MetaCyc:MONOMER-16498; -.
DR   BRENDA; 3.2.1.21; 6451.
DR   EvolutionaryTrace; O93785; -.
DR   GO; GO:0008422; F:beta-glucosidase activity; IDA:CACAO.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF36; KLOTHO (MAMMALIAN AGING-ASSOCIATED PROTEIN) HOMOLOG; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 1.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3AHY, ECO:0007829|PDB:4GXP}.
SQ   SEQUENCE   466 AA;  52241 MW;  73CAB6EFC0A265B7 CRC64;
     MLPKDFQWGF ATAAYQIEGA VDQDGRGPSI WDTFCAQPGK IADGSSGVTA CDSYNRTAED
     IALLKSLGAK SYRFSISWSR IIPEGGRGDA VNQAGIDHYV KFVDDLLDAG ITPFITLFHW
     DLPEGLHQRY GGLLNRTEFP LDFENYARVM FRALPKVRNW ITFNEPLCSA IPGYGSGTFA
     PGRQSTSEPW TVGHNILVAH GRAVKAYRDD FKPASGDGQI GIVLNGDFTY PWDAADPADK
     EAAERRLEFF TAWFADPIYL GDYPASMRKQ LGDRLPTFTP EERALVHGSN DFYGMNHYTS
     NYIRHRSSPA SADDTVGNVD VLFTNKQGNC IGPETQSPWL RPCAAGFRDF LVWISKRYGY
     PPIYVTENGT SIKGESDLPK EKILEDDFRV KYYNEYIRAM VTAVELDGVN VKGYFAWSLM
     DNFEWADGYV TRFGVTYVDY ENGQKRFPKK SAKSLKPLFD ELIAAA
//