Formaldehyde ferredoxin oxidoreductase

Preferred order of sections

Names and origin

Protein names

Submitted name:
Formaldehyde ferredoxin oxidoreductase EMBL AAD02881.1

Gene names

Name:

for EMBL AAD02881.1

Organism

Pyrococcus furiosus EMBL AAD02881.1

Taxonomic identifier

2261 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Pyrococcus

Protein attributes

Sequence length	619 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	4Fe-4S PDB 1B4N PDB 1B25 Calcium PDB 1B4N Iron Iron-sulfur Metal-binding
Technical term	3D-structure PDB 1B4N PDB 1B25
Gene Ontology (GO)
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Sites

Metal binding

179

1

Calcium; via carbonyl oxygen PDB 1B4N

Metal binding

284

1

Iron-sulfur (4Fe-4S) PDB 1B4N PDB 1B25

Metal binding

287

1

Iron-sulfur (4Fe-4S) PDB 1B4N PDB 1B25

Metal binding

291

1

Iron-sulfur (4Fe-4S) PDB 1B4N PDB 1B25

Metal binding

304

1

Calcium PDB 1B4N

Metal binding

306

1

Calcium PDB 1B4N

Metal binding

491

1

Iron-sulfur (4Fe-4S) PDB 1B4N PDB 1B25

Binding site

308

1

Tungstopterin (covalent) PDB 1B4N

Binding site

437

1

Tungstopterin (covalent) PDB 1B4N PDB 1B25

Experimental info

Non-terminal residue

619

1

EMBL AAD02881.1

Sequences

Sequence

Length

Mass (Da)

Tools

O93738 [UniParc].

Last modified May 1, 1999. Version 1.
Checksum: A18F7A2E1EB70056
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FASTA

619

68,774

        10         20         30         40         50         60 
MYGWWGRILR VNLTTGEVKV QEYPEEVAKK FIGGRGLAAW ILWNEARGVE PLSPENKLIF 

        70         80         90        100        110        120 
AAGPFNGLPT PSGGKLVVAA KSPLTGGYGD GNLGTMASVH LRRAGYDALV VEGKAKKPVY 

       130        140        150        160        170        180 
IYIEDDNVSI LSAEGLWGKT TFETERELKE IHGKNVGVLT IGPAGENLVK YAVVISQEGR 

       190        200        210        220        230        240 
AAGRPGMGAV MGSKKLKAVV IRGTKEIPVA DKEELKKLSQ EAYNEILNSP GYPFWKRQGT 

       250        260        270        280        290        300 
MAAVEWCNTN YALPTRNFSD GYFEFARSID GYTMEGMKVQ QRGCPYCNMP CGNVVLDAEG 

       310        320        330        340        350        360 
QESELDYENV ALLGSNLGIG KLNEVSVLNR IADEMGMDTI SLGVSIAHVM EAVERGILKE 

       370        380        390        400        410        420 
GPTFGDFKGA KQLALDIAYR KGELGNLAAE GVKAMAEKLG THDFAMHVKG LEVSGYNCYI 

       430        440        450        460        470        480 
YPAMALAYGT SAIGAHHKEA WVIAWEIGTA PIEGEKAEKV EYKISYDPIK AQKVVELQRL 

       490        500        510        520        530        540 
RGGLFEMLTA CRLPWVEVGL SLDYYPKLLK AITGVTYTWD DLYKAADRVY SLIRAYWVRE 

       550        560        570        580        590        600 
FNGKWDRKMD YPPKRWFTEG LKSGPHKGEH LDEKKYDELL SEYYRIRGWD ERGIPKKETL 

       610 
KELDLDFVIP ELEKVTNLE

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References

[1]	"Purification and molecular characterization of the tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus: the third of a putative five-member tungstoenzyme family." Roy R., Mukund S., Schut G.J., Dunn D.M., Weiss R., Adams M.W. J. Bacteriol. 181:1171-1180(1999) [PubMed: 9973343] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications." Hu Y., Faham S., Roy R., Adams M.W., Rees D.C. J. Mol. Biol. 286:899-914(1999) [PubMed: 10024458] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH CALCIUM; IRON-SULFUR (4FE-4S) AND TUNGSTOPTERIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF102769 Genomic DNA. Translation: AAD02881.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1B25	X-ray	1.85	A/B/C/D	1-619	[»]
1B4N	X-ray	2.40	A/B/C/D	1-619	[»]

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

InterPro

IPR013985. Ald_Fedxn_OxRdtase_3.
IPR013983. Ald_Fedxn_OxRdtase_N.
IPR001203. OxRdtase_Ald_Fedxn_C.
[Graphical view]

Gene3D

G3DSA:1.10.599.10. Oxred_Ald_Fedxn_3. 1 hit.
G3DSA:3.60.9.10. Oxred_Ald_Fedxn_N. 1 hit.

Pfam

PF01314. AFOR_C. 1 hit.
PF02730. AFOR_N. 1 hit.
[Graphical view]

SMART

SM00790. AFOR_N. 1 hit.
[Graphical view]

SUPFAM

SSF48310. Oxred_Ald_Fedxn_C. 1 hit.
SSF56228. Oxred_Ald_Fedxn_N. 1 hit.

ProtoNet

Search...

Entry information

Entry name

O93738_9EURY

Accession

Primary (citable) accession number: O93738

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 1999
Last sequence update:	May 1, 1999
Last modified:	June 28, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)