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Protein

DNA ligase

Gene

lig

Organism
Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei249ATPUniRule annotation1
Active sitei251N6-AMP-lysine intermediateUniRule annotation1
Binding sitei256ATPUniRule annotation1
Binding sitei271ATPUniRule annotation1
Binding sitei301ATPUniRule annotation1
Binding sitei341ATPUniRule annotation1
Binding sitei416ATPUniRule annotation1
Binding sitei422ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:PAE0833
OrganismiPyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827)
Taxonomic identifieri178306 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaePyrobaculum
Proteomesi
  • UP000002439 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596111 – 584DNA ligaseAdd BLAST584

Interactioni

Protein-protein interaction databases

STRINGi178306.PAE0833

Structurei

3D structure databases

ProteinModelPortaliO93723
SMRiO93723
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
HOGENOMiHOG000036008
InParanoidiO93723
KOiK10747
OMAiWIKYKRD
OrthoDBiPOG093Z03L0

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

O93723-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFGELVKAL AAIEATTQRT TMVKLLVSLF KKASPEEVGK IVYFILGDLR
60 70 80 90 100
PPWEGVELGV AEKLCLRAVS KATGAAVSEL EALYKKTGDV GEAARRALAA
110 120 130 140 150
SKRPGLLAFG SQKPLEVSEV YDTLLKVARA TGEGAQDMKV ALLSSLFARA
160 170 180 190 200
TPEEGKYIAR FVVGKLRLGV ADMTIIEALS DAYGVNKEAL EKAYHIYPDL
210 220 230 240 250
GRLAKHVAEG KPLDEIRITP GVPVLPMLAQ RLSSASEILA KLGGSAICEY
260 270 280 290 300
KYDGERAQIH LTPGGVKIFS RRLEDITHAY PDVVKAVKEA VSAKEAILEG
310 320 330 340 350
EIVAVDPDTG DMLPFQELMH RKRKHDVATA VELYPTVLYL FDVLYVDGED
360 370 380 390 400
LTEEPLIYRR VRLSEIVCET DKVSIAKWRI FDNAEAVDVF FHESVSMGTE
410 420 430 440 450
GLICKSPSSI YEMGARGWNW IKYKRDYRSE MIDTVDLVVV GAFHGRGKRA
460 470 480 490 500
GLYGAFLLAA YDPSTDMFYT VCKVGSGFTD ADLKKMYEIL QPFKIPHRHP
510 520 530 540 550
RVVSKMEADV WFVPQVVIEV IGAEITLSPL HTCCLGAVRP GVGLAVRFPR
560 570 580
FTGRYRSDKS PEQATTVAEM LELYKRQKKV VQPE
Length:584
Mass (Da):64,568
Last modified:June 20, 2001 - v2
Checksum:i7CB44E8A5B0DBA0A
GO

Sequence cautioni

The sequence AAD00532 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82370 Genomic DNA Translation: AAD00532.1 Different initiation.
AE009441 Genomic DNA Translation: AAL63064.1

Genome annotation databases

EnsemblBacteriaiAAL63064; AAL63064; PAE0833
KEGGipai:PAE0833
PATRICifig|178306.9.peg.613

Similar proteinsi

Entry informationi

Entry nameiDNLI_PYRAE
AccessioniPrimary (citable) accession number: O93723
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health