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Protein

Tricorn protease-interacting factor F3

Gene

trf3

Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proteases F1, F2 and F3 degrade oligopeptides produced by Tricorn (themselves probably produced by the proteasome), yielding free amino acids.

Cofactori

Zn2+1 PublicationNote: Binds 1 zinc ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101SubstrateBy similarity1
Metal bindingi265Zinc; catalytic1
Active sitei266Proton acceptorCurated1
Metal bindingi269Zinc; catalytic1
Metal bindingi288Zinc; catalytic1
Sitei351Transition state stabilizerBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM01.021.

Names & Taxonomyi

Protein namesi
Recommended name:
Tricorn protease-interacting factor F3 (EC:3.4.11.-)
Gene namesi
Name:trf3
Ordered Locus Names:Ta0815
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001024 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000951121 – 780Tricorn protease-interacting factor F3Add BLAST780

Proteomic databases

PRIDEiO93655.

Interactioni

Subunit structurei

Part of the tricorn proteolytic complex.1 Publication

Protein-protein interaction databases

STRINGi273075.Ta0815.

Structurei

Secondary structure

1780
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 13Combined sources11
Turni14 – 17Combined sources4
Beta strandi18 – 27Combined sources10
Beta strandi32 – 35Combined sources4
Beta strandi40 – 46Combined sources7
Beta strandi57 – 62Combined sources6
Beta strandi66 – 78Combined sources13
Beta strandi80 – 91Combined sources12
Beta strandi95 – 99Combined sources5
Turni101 – 103Combined sources3
Helixi105 – 107Combined sources3
Beta strandi119 – 127Combined sources9
Beta strandi132 – 137Combined sources6
Beta strandi139 – 152Combined sources14
Helixi160 – 162Combined sources3
Beta strandi165 – 168Combined sources4
Beta strandi171 – 177Combined sources7
Beta strandi180 – 188Combined sources9
Helixi194 – 210Combined sources17
Beta strandi215 – 224Combined sources10
Beta strandi237 – 241Combined sources5
Helixi242 – 245Combined sources4
Beta strandi249 – 251Combined sources3
Helixi253 – 269Combined sources17
Turni273 – 275Combined sources3
Beta strandi276 – 280Combined sources5
Helixi281 – 283Combined sources3
Helixi284 – 302Combined sources19
Turni304 – 306Combined sources3
Helixi308 – 315Combined sources8
Helixi317 – 323Combined sources7
Beta strandi326 – 328Combined sources3
Beta strandi337 – 339Combined sources3
Turni342 – 345Combined sources4
Helixi348 – 365Combined sources18
Helixi367 – 381Combined sources15
Beta strandi384 – 386Combined sources3
Helixi388 – 399Combined sources12
Helixi403 – 412Combined sources10
Beta strandi413 – 415Combined sources3
Beta strandi417 – 434Combined sources18
Beta strandi440 – 442Combined sources3
Beta strandi447 – 453Combined sources7
Beta strandi456 – 462Combined sources7
Beta strandi464 – 469Combined sources6
Beta strandi473 – 477Combined sources5
Helixi478 – 480Combined sources3
Beta strandi482 – 487Combined sources6
Helixi490 – 498Combined sources9
Helixi499 – 502Combined sources4
Helixi505 – 521Combined sources17
Beta strandi522 – 524Combined sources3
Helixi526 – 533Combined sources8
Helixi534 – 536Combined sources3
Helixi542 – 556Combined sources15
Helixi563 – 577Combined sources15
Helixi583 – 599Combined sources17
Helixi601 – 608Combined sources8
Helixi609 – 616Combined sources8
Helixi619 – 632Combined sources14
Helixi636 – 644Combined sources9
Helixi649 – 659Combined sources11
Helixi665 – 676Combined sources12
Helixi682 – 692Combined sources11
Helixi696 – 704Combined sources9
Helixi706 – 717Combined sources12
Beta strandi719 – 721Combined sources3
Helixi722 – 734Combined sources13
Turni735 – 737Combined sources3
Helixi741 – 746Combined sources6
Helixi754 – 775Combined sources22
Turni776 – 779Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z1WX-ray2.70A1-780[»]
1Z5HX-ray2.30A/B1-780[»]
3Q7JX-ray2.91A/B1-780[»]
ProteinModelPortaliO93655.
SMRiO93655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO93655.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni230 – 234Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

eggNOGiarCOG02969. Archaea.
COG0308. LUCA.
HOGENOMiHOG000106482.
KOiK13722.
OMAiITFREIY.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVEKYDLTL DFDIQKRTFN GTETITADAG DIVLDAVGLQ INWMKVNGRD
60 70 80 90 100
TAFTYDGQTV RAPGDSQPQK IEISFAGKVS DSLSGIYYAG RENGMITTHF
110 120 130 140 150
EATDARRMFP CVDHPAYKAV FAITVVIDKD YDAISNMPPK RIEVSERKVV
160 170 180 190 200
EFQDTPRMST YLLYVGIGKF RYEYEKYRDI DLILASLKDI RSKYPLDMAR
210 220 230 240 250
KSVEFYENYF GIPYALPKMH LISVPEFGAG AMENWGAITF REIYMDIAEN
260 270 280 290 300
SAVTVKRNSA NVIAHEIAHQ WFGDLVTMKW WNDLWLNESF ATFMSYKTMD
310 320 330 340 350
TLFPEWSFWG DFFVSRTSGA LRSDSLKNTH PIEVDVRDPD EISQIFDEIS
360 370 380 390 400
YGKGASILRM IEDYAGYEEF RKGISKYLND HKFGNAEGSD LWTAIEDVSG
410 420 430 440 450
KPVKRVMEYW IKNPGYPVIK LKRNGRKITM YQTRFLLNGE EEGRWPVPVN
460 470 480 490 500
IKKKDGVERI LLEDEASIEA DGLIKINADS AGFYRVLYDD ATFSDVMGHY
510 520 530 540 550
RDLSPLDRIG LVDDLFAFLL SGHIDPETYR QRIRNFFDDE DHNVITAIVG
560 570 580 590 600
QMEYLRMLTH AFDDDARAFC RSRMQFLTGK QDENLKIALG RVSRLYVMVD
610 620 630 640 650
ESYAEEMSKL FKDFDSAEPE MRSSIATAYA LVTGDLKGLL EKFRSVDRDE
660 670 680 690 700
DRVRIISAFG KLKSNTDLST VYGMVEKTEI KKQDMISFFS SALETLPGRE
710 720 730 740 750
FIFANLDRII RLVIRYFTGN RTASRTVEMM IPVIGLDHPD AEDIVRNIGS
760 770 780
KNISMGLAKG IEMLAVNRKL VERIRQTAVK
Length:780
Mass (Da):89,380
Last modified:May 1, 1999 - v1
Checksum:iF499AB342BAB9218
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081952 Genomic DNA. Translation: AAC98290.1.
AL445065 Genomic DNA. Translation: CAC11944.1.
PIRiT37456.
RefSeqiWP_010901227.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC11944; CAC11944; CAC11944.
GeneIDi1456360.
KEGGitac:Ta0815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081952 Genomic DNA. Translation: AAC98290.1.
AL445065 Genomic DNA. Translation: CAC11944.1.
PIRiT37456.
RefSeqiWP_010901227.1. NC_002578.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z1WX-ray2.70A1-780[»]
1Z5HX-ray2.30A/B1-780[»]
3Q7JX-ray2.91A/B1-780[»]
ProteinModelPortaliO93655.
SMRiO93655.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273075.Ta0815.

Protein family/group databases

MEROPSiM01.021.

Proteomic databases

PRIDEiO93655.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC11944; CAC11944; CAC11944.
GeneIDi1456360.
KEGGitac:Ta0815.

Phylogenomic databases

eggNOGiarCOG02969. Archaea.
COG0308. LUCA.
HOGENOMiHOG000106482.
KOiK13722.
OMAiITFREIY.

Miscellaneous databases

EvolutionaryTraceiO93655.
PROiO93655.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRF3_THEAC
AccessioniPrimary (citable) accession number: O93655
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1999
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.