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Protein

DNA polymerase delta subunit 2

Gene

pold2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The function of the small subunit is not yet clear.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase delta subunit 2 (EC:2.7.7.7)
Alternative name(s):
XlCdc1
Gene namesi
Name:pold2
Synonyms:cdc1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-999393. pold2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 463463DNA polymerase delta subunit 2PRO_0000096168Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of subunits of 125 kDa, 50 kDa, 66 kDa and 12 kDa.By similarity

Protein-protein interaction databases

IntActiO93610. 1 interaction.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG051396.
KOiK02328.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTDLAISGG PGLLTAPSEV QSTFTRVSNT QYSNCSSIFR LGERTFTRQY
60 70 80 90 100
AHIYATRLEQ MRPLLIKSAK QRWGDDIAVR KLCELQGGEK CCVIGTLFKS
110 120 130 140 150
MELQPSILRE ISEEHNLLPQ PARQKYISDS DELILEDELQ RIKLEGATDV
160 170 180 190 200
QQLVTGAVLA VLGAEEDAGK FVVEDFCLTS LPVQSPLPRL SEDRFVLLTS
210 220 230 240 250
GLGLGGGSGD SLMGLQLLLD LVTGQAGAEE DQGCAARISR VILAGNLLSE
260 270 280 290 300
NTQGKDSLNK AKYLSKKTQA ASVEAVKMLD EILLQMSGSV SVDVMPGAFD
310 320 330 340 350
PTNYILPQQP LHRCMFPQSA LYSTLQLVTN PYEAEIDGVR FLGTSGQNIG
360 370 380 390 400
DIYKYSSMQD YLDILEWTLQ VGHLCPTAPD TLGCYPFYKS DPFILQNCPH
410 420 430 440 450
VYFCGSAPKF SCKEVTGAEG QRVLLLTVPE FCSTQTACLV NLRTLQCQPI
460
SFSGFGADDE LGD
Length:463
Mass (Da):50,648
Last modified:November 1, 1998 - v1
Checksum:i77026EF1897A638D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010836 mRNA. Translation: CAA09373.1.
BC047262 mRNA. Translation: AAH47262.1.
RefSeqiNP_001080101.1. NM_001086632.1.
UniGeneiXl.4169.

Genome annotation databases

GeneIDi379793.
KEGGixla:379793.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010836 mRNA. Translation: CAA09373.1.
BC047262 mRNA. Translation: AAH47262.1.
RefSeqiNP_001080101.1. NM_001086632.1.
UniGeneiXl.4169.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO93610. 1 interaction.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379793.
KEGGixla:379793.

Organism-specific databases

CTDi5425.
XenbaseiXB-GENE-999393. pold2.

Phylogenomic databases

HOVERGENiHBG051396.
KOiK02328.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
IPR024826. DNA_pol_delta/II_ssu.
[Graphical view]
PANTHERiPTHR10416. PTHR10416. 1 hit.
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPOD2_XENLA
AccessioniPrimary (citable) accession number: O93610
Secondary accession number(s): Q5D0A2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.