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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 53Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini54 – 63CytoplasmicSequence analysis10
Transmembranei64 – 85Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini86 – 101ExtracellularSequence analysisAdd BLAST16
Transmembranei102 – 123Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini124 – 146CytoplasmicSequence analysisAdd BLAST23
Transmembranei147 – 170Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini171 – 195ExtracellularSequence analysisAdd BLAST25
Transmembranei196 – 217Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini218 – 268CytoplasmicSequence analysisAdd BLAST51
Transmembranei269 – 290Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini291 – 298ExtracellularSequence analysis8
Transmembranei299 – 321Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini322 – 395CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000701911 – 395Thyrotropin-releasing hormone receptorAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO93603.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025895.

Structurei

3D structure databases

ProteinModelPortaliO93603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO93603.
KOiK04282.
PhylomeDBiO93603.

Family and domain databases

CDDicd14995. 7tmA_TRH-R. 1 hit.
InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
PANTHERiPTHR24243:SF115. PTHR24243:SF115. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiView protein in SMART
SM01381. 7TM_GPCR_Srsx. 1 hit.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O93603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGTGDEQN HTGLLLSSQE FVTAEYQVVT ILLVLLICGL GIVGNIMVVL
60 70 80 90 100
VVLRTKHMRT PTNCYLVSLA VADLMVLVAA GLPNITESLY KSWVYGYVGC
110 120 130 140 150
LCITYLQYLG INASSFSITA FTIERYIAIC HPIKAQFLCT FSRAKKIIIF
160 170 180 190 200
VWSFASVYCM LWFFLLDLNI AVYKDTTVVS CGYKVSRSYY SPIYMMDFGI
210 220 230 240 250
FYVLPMVLAT VLYGLIARIL FLNPIPSDPK ENSNTWKNDM AQQNKTVNSK
260 270 280 290 300
MTNKSFNSTI ASRRQVTKML AVVVVLFAFL WMPYRTLVVV NSFLSSPFQE
310 320 330 340 350
NWFLLFCRIC IYLNSAINPV IYNLMSQKFR AAFRKLCNCH LKRDKKPANY
360 370 380 390
SVALNYNVIK ESDHFSSEIE DITVTNTYLS SAKTSIGDTC LSSEA
Length:395
Mass (Da):44,698
Last modified:November 1, 1998 - v1
Checksum:i291D9BD2718723CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18244 mRNA. Translation: CAA77091.1.
RefSeqiNP_990261.1. NM_204930.1.
UniGeneiGga.457.

Genome annotation databases

GeneIDi395770.
KEGGigga:395770.

Similar proteinsi

Entry informationi

Entry nameiTRFR_CHICK
AccessioniPrimary (citable) accession number: O93603
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: October 25, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families