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Protein

Thyrotropin-releasing hormone receptor

Gene

TRHR

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotropin-releasing hormone receptor
Short name:
TRH-R
Alternative name(s):
Thyroliberin receptor
Gene namesi
Name:TRHR
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence analysisAdd
BLAST
Transmembranei31 – 5323Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini54 – 6310CytoplasmicSequence analysis
Transmembranei64 – 8522Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini86 – 10116ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12322Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini124 – 14623CytoplasmicSequence analysisAdd
BLAST
Transmembranei147 – 17024Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini171 – 19525ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21722Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 26851CytoplasmicSequence analysisAdd
BLAST
Transmembranei269 – 29022Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini291 – 2988ExtracellularSequence analysis
Transmembranei299 – 32123Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini322 – 39574CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Thyrotropin-releasing hormone receptorPRO_0000070191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Disulfide bondi100 ↔ 181PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO93603.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025895.

Structurei

3D structure databases

ProteinModelPortaliO93603.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO93603.
KOiK04282.
PhylomeDBiO93603.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGTGDEQN HTGLLLSSQE FVTAEYQVVT ILLVLLICGL GIVGNIMVVL
60 70 80 90 100
VVLRTKHMRT PTNCYLVSLA VADLMVLVAA GLPNITESLY KSWVYGYVGC
110 120 130 140 150
LCITYLQYLG INASSFSITA FTIERYIAIC HPIKAQFLCT FSRAKKIIIF
160 170 180 190 200
VWSFASVYCM LWFFLLDLNI AVYKDTTVVS CGYKVSRSYY SPIYMMDFGI
210 220 230 240 250
FYVLPMVLAT VLYGLIARIL FLNPIPSDPK ENSNTWKNDM AQQNKTVNSK
260 270 280 290 300
MTNKSFNSTI ASRRQVTKML AVVVVLFAFL WMPYRTLVVV NSFLSSPFQE
310 320 330 340 350
NWFLLFCRIC IYLNSAINPV IYNLMSQKFR AAFRKLCNCH LKRDKKPANY
360 370 380 390
SVALNYNVIK ESDHFSSEIE DITVTNTYLS SAKTSIGDTC LSSEA
Length:395
Mass (Da):44,698
Last modified:November 1, 1998 - v1
Checksum:i291D9BD2718723CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18244 mRNA. Translation: CAA77091.1.
RefSeqiNP_990261.1. NM_204930.1.
UniGeneiGga.457.

Genome annotation databases

GeneIDi395770.
KEGGigga:395770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y18244 mRNA. Translation: CAA77091.1.
RefSeqiNP_990261.1. NM_204930.1.
UniGeneiGga.457.

3D structure databases

ProteinModelPortaliO93603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025895.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO93603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395770.
KEGGigga:395770.

Organism-specific databases

CTDi7201.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000017249.
HOVERGENiHBG007549.
InParanoidiO93603.
KOiK04282.
PhylomeDBiO93603.

Miscellaneous databases

PROiO93603.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002120. TRH_rcpt_1.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00751. THYROLIBRINR.
PR01846. TRHRFAMILY.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the chicken thyrotropin-releasing hormone receptor."
    Sun Y.M., Millar R.P., Ho H., Gershengorn M.C., Illing N.
    Endocrinology 139:3390-3398(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiTRFR_CHICK
AccessioniPrimary (citable) accession number: O93603
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.