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Protein

Cyclic AMP-dependent transcription factor ATF-2

Gene

ATF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3') (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C2H2-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Transferase

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-GGA-3214847. HATs acetylate histones.
R-GGA-450341. Activation of the AP-1 family of transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-2 (EC:2.3.1.48)
Short name:
cAMP-dependent transcription factor ATF-2
Alternative name(s):
Activating transcription factor 2
Gene namesi
Name:ATF2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765801 – 487Cyclic AMP-dependent transcription factor ATF-2Add BLAST487

Proteomic databases

PaxDbiO93602.
PRIDEiO93602.

Expressioni

Gene expression databases

BgeeiENSGALG00000009287.
ExpressionAtlasiO93602. differential.

Interactioni

Subunit structurei

Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Heterodimerization is essential for its transcriptional activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032623.

Structurei

3D structure databases

ProteinModelPortaliO93602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini334 – 397bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni336 – 356Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni362 – 390Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi387 – 396Nuclear export signalBy similarity10

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri7 – 31C2H2-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000020106.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiO93602.
KOiK04450.
OMAiHPESTTN.
OrthoDBiEOG091G0AO8.
PhylomeDBiO93602.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR029836. ATF-2.
IPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19304:SF9. PTHR19304:SF9. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDDKPFLCT APGCGQRFTN EDHLAVHKHK HEMTLKFGPA RNDSVIVADQ
60 70 80 90 100
TPTPTRFLKN CEEVGLFNEL ASPFENEFKK ASEDDIKKMP LDLSPLATPI
110 120 130 140 150
IRNKIEEPSV VETTHQDSPL PHPESTTNDE KEVSLQQTAQ PTSTIVRPAS
160 170 180 190 200
LQVPNVLLTS SDSSVIIQQA IPSPTSSTVI TQAPSSNRPI VPVPGPFPLL
210 220 230 240 250
LHLPNGQTMP VAIPASITNS NVHVPAAVPL VRPVTMVPSI PGIPGPSSPQ
260 270 280 290 300
PVQSEAKLRL KAALTQQHPQ VTNGDTAKGH PSGLVRTQSE EPRPQSLQQP
310 320 330 340 350
ATSTTETPAS PAQPTQQTPN TGGRRRRAAN EDPDEKRRKF LERNRAAASR
360 370 380 390 400
CRQKRKVWVQ SLEKKAEDLS SLNGQLQNEV TLLRNEVAQL KQLLLAHKDC
410 420 430 440 450
PVTAMQKKSG YHTADKDDSS EDISVPSSPH TEAIQHSSVS TSNGVSSTSK
460 470 480
AEAVATSVLT QLADQSSEPG LPQVGVVPPS QAQPSGS
Length:487
Mass (Da):52,407
Last modified:November 1, 1998 - v1
Checksum:iA1F42734D9C6A146
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17724 mRNA. Translation: CAA76838.1.
RefSeqiNP_990235.1. NM_204904.1.
UniGeneiGga.27381.

Genome annotation databases

EnsembliENSGALT00000015107; ENSGALP00000015091; ENSGALG00000009287.
GeneIDi395727.
KEGGigga:395727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17724 mRNA. Translation: CAA76838.1.
RefSeqiNP_990235.1. NM_204904.1.
UniGeneiGga.27381.

3D structure databases

ProteinModelPortaliO93602.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032623.

Proteomic databases

PaxDbiO93602.
PRIDEiO93602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015107; ENSGALP00000015091; ENSGALG00000009287.
GeneIDi395727.
KEGGigga:395727.

Organism-specific databases

CTDi1386.

Phylogenomic databases

eggNOGiKOG1414. Eukaryota.
ENOG4111CH5. LUCA.
GeneTreeiENSGT00390000020106.
HOGENOMiHOG000220894.
HOVERGENiHBG004300.
InParanoidiO93602.
KOiK04450.
OMAiHPESTTN.
OrthoDBiEOG091G0AO8.
PhylomeDBiO93602.

Enzyme and pathway databases

ReactomeiR-GGA-3214847. HATs acetylate histones.
R-GGA-450341. Activation of the AP-1 family of transcription factors.

Miscellaneous databases

PROiO93602.

Gene expression databases

BgeeiENSGALG00000009287.
ExpressionAtlasiO93602. differential.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR029836. ATF-2.
IPR004827. bZIP.
IPR016378. TF_CRE-BP1-typ.
IPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PANTHERiPTHR19304:SF9. PTHR19304:SF9. 1 hit.
PfamiPF00170. bZIP_1. 1 hit.
[Graphical view]
PIRSFiPIRSF003153. ATF2_CRE-BP1. 1 hit.
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATF2_CHICK
AccessioniPrimary (citable) accession number: O93602
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.