UniProtKB - O93599 (O93599_DANRE)
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Protein
Signal transducer and activator of transcription
Gene
stat3
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA binding transcription factor activity Source: InterPro
- signal transducer activity Source: UniProtKB-UniRule
GO - Biological processi
- axis elongation Source: ZFIN
- cardiac muscle tissue regeneration Source: ZFIN
- cell migration involved in gastrulation Source: ZFIN
- epithelial to mesenchymal transition Source: ZFIN
- establishment of cell polarity Source: ZFIN
- establishment of planar polarity Source: ZFIN
- inner ear receptor cell development Source: ZFIN
- JAK-STAT cascade Source: ZFIN
- motor neuron axon guidance Source: ZFIN
- positive regulation of glial cell proliferation Source: ZFIN
- posterior lateral line neuromast hair cell development Source: ZFIN
- regeneration Source: ZFIN
- regulation of cell proliferation Source: ZFIN
- regulation of cell shape Source: ZFIN
- regulation of cell size Source: ZFIN
- retina morphogenesis in camera-type eye Source: ZFIN
- skeletal system development Source: ZFIN
- transcription, DNA-templated Source: UniProtKB-KW
Keywordsi
Molecular function | ActivatorUniRule annotation, DNA-bindingUniRule annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Enzyme and pathway databases
Reactomei | R-DRE-1059683 Interleukin-6 signaling R-DRE-1433557 Signaling by SCF-KIT R-DRE-186763 Downstream signal transduction R-DRE-6783783 Interleukin-10 signaling R-DRE-6785807 Interleukin-4 and 13 signaling R-DRE-8849474 PTK6 Activates STAT3 R-DRE-8854691 Interleukin-20 family signaling R-DRE-8875791 MET activates STAT3 R-DRE-8983432 Interleukin-15 signaling R-DRE-8984722 Interleukin-35 Signalling R-DRE-9008059 Interleukin-37 signaling R-DRE-9020933 Interleukin-23 signaling R-DRE-9020956 Interleukin-27 signaling R-DRE-9020958 Interleukin-21 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Signal transducer and activator of transcriptionUniRule annotation |
Gene namesi | Name:stat3Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-980526-68 stat3 |
Subcellular locationi
Keywords - Cellular componenti
CytoplasmUniRule annotation, NucleusUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 581 – 671 | SH2InterPro annotationAdd BLAST | 91 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 140 – 167 | Sequence analysisAdd BLAST | 28 | |
Coiled coili | 194 – 217 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 271 – 291 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the transcription factor STAT family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG3667 Eukaryota ENOG410XPN8 LUCA |
GeneTreei | ENSGT00760000119236 |
HOVERGENi | HBG055669 |
KOi | K04692 |
TreeFami | TF318648 |
Family and domain databases
CDDi | cd10374 SH2_STAT3, 1 hit |
Gene3Di | 1.10.532.101 hit 2.60.40.6301 hit 3.30.505.101 hit |
InterProi | View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR000980 SH2 IPR036860 SH2_dom_sf IPR001217 STAT IPR035855 STAT3_SH2 IPR036535 STAT_N_sf IPR013800 STAT_TF_alpha IPR015988 STAT_TF_coiled-coil IPR013801 STAT_TF_DNA-bd IPR012345 STAT_TF_DNA-bd_N IPR013799 STAT_TF_prot_interaction |
PANTHERi | PTHR11801 PTHR11801, 1 hit |
Pfami | View protein in Pfam PF00017 SH2, 1 hit PF01017 STAT_alpha, 1 hit PF02864 STAT_bind, 1 hit PF02865 STAT_int, 1 hit |
SMARTi | View protein in SMART SM00964 STAT_int, 1 hit |
SUPFAMi | SSF47655 SSF47655, 1 hit SSF48092 SSF48092, 1 hit SSF49417 SSF49417, 1 hit SSF55550 SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001 SH2, 1 hit |
i Sequence
Sequence statusi: Complete.
O93599-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQWNQLQQL ETRYLEQLYH LYSDSFPMEL RQFLAPWIES QDWAYAANKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQENNVLYQ HNLRRIKQHL QSKYLEKPME
110 120 130 140 150
IARIVARCLW EEQRLLQTAT TAQQDGQVAH PTGTVVTEKQ QILEHNLQDI
160 170 180 190 200
RKRVQDMEQK MKMLENLQDD FDFNYKTLKS AGELSQDLNG NSQAAATRQK
210 220 230 240 250
MSQLEQMLSA LDQLRRQIVT EMAGLLSAMD FVQKNLTDEE LADWKRRQQI
260 270 280 290 300
ACIGGPPNIC LDRLETWITS LAESQLQIRQ QIRKLEELQQ KVSYKGDPII
310 320 330 340 350
QHRPALEEKI VDLFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTTKV
360 370 380 390 400
RLLVKFPELN YQLKIKVCID KESGDVAAIR GSRKFNILGT NTKVMNMEES
410 420 430 440 450
NNGSLSAEFK HLTLREQRCG NGGRTNSDAS LIVTEELHLI TFETEVYHQG
460 470 480 490 500
LKIDLETHSL PVVVISNICQ MPNAWASILW YNMLTNHPKN VNFFTKPPVG
510 520 530 540 550
TWDQVAEVLS WQFSSTTKRG LTIEQLTTLA EKLLGPCVNY SGCQITWAKF
560 570 580 590 600
CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS
610 620 630 640 650
PKPPGTFLLR FSESSKEGGI TFTWVEKDIN GKTQIQSVEP YTKQQLNSMS
660 670 680 690 700
FAEIIMGYKI MDATNILVSP LVYLYPDIPK EEAFGKYCRP EAHPDTEFPD
710 720 730 740 750
TGCVTQPYLK TKFICVTPCP SVFMDFPDSE LLGNGFPGTN SGNTSDLFPM
760 770 780 790 800
SPRTLDSLMH NEAAEANPGP LESLTLDMEL SSDHASPMRE GFAASTVSDM
DTCRNA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR847978 Genomic DNA No translation available. AJ005693 mRNA Translation: CAA06677.1 |
RefSeqi | NP_571554.1, NM_131479.1 |
UniGenei | Dr.132860 |
Genome annotation databases
Ensembli | ENSDART00000104519; ENSDARP00000095292; ENSDARG00000022712 |
GeneIDi | 30767 |
KEGGi | dre:30767 |
Similar proteinsi
Entry informationi
Entry namei | O93599_DANRE | |
Accessioni | O93599Primary (citable) accession number: O93599 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1998 |
Last sequence update: | November 1, 1998 | |
Last modified: | March 28, 2018 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |