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Protein

Signal transducer and activator of transcription

Gene

stat3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cardiac muscle tissue regeneration Source: ZFIN
  • cell migration involved in gastrulation Source: ZFIN
  • epithelial to mesenchymal transition Source: ZFIN
  • establishment of cell polarity Source: ZFIN
  • establishment of planar polarity Source: ZFIN
  • inner ear receptor cell development Source: ZFIN
  • JAK-STAT cascade Source: ZFIN
  • motor neuron axon guidance Source: ZFIN
  • positive regulation of glial cell proliferation Source: ZFIN
  • posterior lateral line neuromast hair cell development Source: ZFIN
  • regeneration Source: ZFIN
  • retina morphogenesis in camera-type eye Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

ActivatorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-1059683. Interleukin-6 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-186763. Downstream signal transduction.
R-DRE-8849474. PTK6 Activates STAT3.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcriptionUniRule annotation
Gene namesi
Name:stat3Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-980526-68. stat3.

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, NucleusUniRule annotation

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095292.

Structurei

3D structure databases

SMRiO93599. Positions 135-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini581 – 67191SH2InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili140 – 16728Sequence analysisAdd
BLAST
Coiled coili194 – 21724Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the transcription factor STAT family.UniRule annotation
Contains 1 SH2 domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainUniRule annotation

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK04692.
OrthoDBiEOG73JKTT.
PhylomeDBiO93599.
TreeFamiTF318648.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93599-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQWNQLQQL ETRYLEQLYH LYSDSFPMEL RQFLAPWIES QDWAYAANKE
60 70 80 90 100
SHATLVFHNL LGEIDQQYSR FLQENNVLYQ HNLRRIKQHL QSKYLEKPME
110 120 130 140 150
IARIVARCLW EEQRLLQTAT TAQQDGQVAH PTGTVVTEKQ QILEHNLQDI
160 170 180 190 200
RKRVQDMEQK MKMLENLQDD FDFNYKTLKS AGELSQDLNG NSQAAATRQK
210 220 230 240 250
MSQLEQMLSA LDQLRRQIVT EMAGLLSAMD FVQKNLTDEE LADWKRRQQI
260 270 280 290 300
ACIGGPPNIC LDRLETWITS LAESQLQIRQ QIRKLEELQQ KVSYKGDPII
310 320 330 340 350
QHRPALEEKI VDLFRNLMKS AFVVERQPCM PMHPDRPLVI KTGVQFTTKV
360 370 380 390 400
RLLVKFPELN YQLKIKVCID KESGDVAAIR GSRKFNILGT NTKVMNMEES
410 420 430 440 450
NNGSLSAEFK HLTLREQRCG NGGRTNSDAS LIVTEELHLI TFETEVYHQG
460 470 480 490 500
LKIDLETHSL PVVVISNICQ MPNAWASILW YNMLTNHPKN VNFFTKPPVG
510 520 530 540 550
TWDQVAEVLS WQFSSTTKRG LTIEQLTTLA EKLLGPCVNY SGCQITWAKF
560 570 580 590 600
CKENMAGKGF SFWVWLDNII DLVKKYILAL WNEGYIMGFI SKERERAILS
610 620 630 640 650
PKPPGTFLLR FSESSKEGGI TFTWVEKDIN GKTQIQSVEP YTKQQLNSMS
660 670 680 690 700
FAEIIMGYKI MDATNILVSP LVYLYPDIPK EEAFGKYCRP EAHPDTEFPD
710 720 730 740 750
TGCVTQPYLK TKFICVTPCP SVFMDFPDSE LLGNGFPGTN SGNTSDLFPM
760 770 780 790 800
SPRTLDSLMH NEAAEANPGP LESLTLDMEL SSDHASPMRE GFAASTVSDM

DTCRNA
Length:806
Mass (Da):92,151
Last modified:November 1, 1998 - v1
Checksum:i74BC4EA401C3C942
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847978 Genomic DNA. No translation available.
AJ005693 mRNA. Translation: CAA06677.1.
RefSeqiNP_571554.1. NM_131479.1.
UniGeneiDr.132860.

Genome annotation databases

EnsembliENSDART00000104519; ENSDARP00000095292; ENSDARG00000022712.
GeneIDi30767.
KEGGidre:30767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR847978 Genomic DNA. No translation available.
AJ005693 mRNA. Translation: CAA06677.1.
RefSeqiNP_571554.1. NM_131479.1.
UniGeneiDr.132860.

3D structure databases

SMRiO93599. Positions 135-718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000095292.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000104519; ENSDARP00000095292; ENSDARG00000022712.
GeneIDi30767.
KEGGidre:30767.

Organism-specific databases

CTDi6774.
ZFINiZDB-GENE-980526-68. stat3.

Phylogenomic databases

eggNOGiKOG3667. Eukaryota.
ENOG410XPN8. LUCA.
GeneTreeiENSGT00760000119236.
HOVERGENiHBG055669.
KOiK04692.
OrthoDBiEOG73JKTT.
PhylomeDBiO93599.
TreeFamiTF318648.

Enzyme and pathway databases

ReactomeiR-DRE-1059683. Interleukin-6 signaling.
R-DRE-1433557. Signaling by SCF-KIT.
R-DRE-186763. Downstream signal transduction.
R-DRE-8849474. PTK6 Activates STAT3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.532.10. 1 hit.
1.20.1050.20. 1 hit.
2.60.40.630. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR008967. p53-like_TF_DNA-bd.
IPR000980. SH2.
IPR001217. STAT.
IPR013800. STAT_TF_alpha.
IPR015988. STAT_TF_coiled-coil.
IPR013801. STAT_TF_DNA-bd.
IPR012345. STAT_TF_DNA-bd_sub.
IPR013799. STAT_TF_prot_interaction.
[Graphical view]
PANTHERiPTHR11801. PTHR11801. 2 hits.
PfamiPF00017. SH2. 1 hit.
PF01017. STAT_alpha. 1 hit.
PF02864. STAT_bind. 1 hit.
PF02865. STAT_int. 1 hit.
[Graphical view]
SMARTiSM00964. STAT_int. 1 hit.
[Graphical view]
SUPFAMiSSF47655. SSF47655. 1 hit.
SSF48092. SSF48092. 1 hit.
SSF49417. SSF49417. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Oates A.C.
    Thesis (1998), University of Melbourne, Australia
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiO93599_DANRE
AccessioniPrimary (citable) accession number: O93599
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.