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Protein

Tyrosine-protein kinase

Gene

jak2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei845 – 8451ATPUniRule annotation
Active sitei939 – 9391Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi818 – 8269ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

  • blood vessel morphogenesis Source: ZFIN
  • erythrocyte differentiation Source: ZFIN
  • hemopoiesis Source: ZFIN
  • JAK-STAT cascade Source: ZFIN
  • positive regulation of JAK-STAT cascade Source: ZFIN
  • positive regulation of transcription from RNA polymerase II promoter Source: ZFIN
  • primitive hemopoiesis Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 928.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:jak2aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-980526-481. jak2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107572.

Structurei

3D structure databases

SMRiO93596. Positions 803-1095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 346331FERMInterPro annotationAdd
BLAST
Domaini367 – 46599SH2InterPro annotationAdd
BLAST
Domaini509 – 773265Protein kinaseInterPro annotationAdd
BLAST
Domaini812 – 1089278Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 2 protein kinase domains.UniRule annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
KOiK04447.
PhylomeDBiO93596.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLANTENEQ KQASGAALQV RLYCCRDEAG VISYPAGEYT AEELSVTAAK
60 70 80 90 100
QCGVSPVHCA LFGLMRERDR VWLPPNHIFK IEPSANETLL FRVRFYFPGW
110 120 130 140 150
YGSGCSSARR YGLSRSSEAP VCDDITTAYL CAQWRSDFLS GAVSVPVSLE
160 170 180 190 200
FQEECLGLAV LDIMRLAKEK GKSPVDIYNH SSYKSFLPKN MREHIQNQHL
210 220 230 240 250
VTRKRIRFRF RRFLQQFGSC KAAPRELKLK YVVSLETLQP AFYSEHFRVS
260 270 280 290 300
EASAGSVTIV VSGDRGIQWC RAAAPEPEDL QVYCDFSDVI DISIKQGTKD
310 320 330 340 350
GSVENRIVTI NRQDSQTLEL EFQSLSEALS FVSLIDGYYR LTTDAHHYLC
360 370 380 390 400
KEVAPPRLLE AIQINCHGPL STEFAVSRLR RCEGQPGVYI LRCSPKDYDR
410 420 430 440 450
YFLSFMVEAE GQLELKHCLV LRSLSGEFVL SGARCSFSSL SELLARYQKE
460 470 480 490 500
ALRSDTHVFQ LRRCCPPRSK DKSNLLVCRT HQGSEVCAPS SEHRLVNQMI
510 520 530 540 550
FHKIHREDLQ TTEGLGQGTF TQVFRGIRRE VGDYGEVHKM EVVMKILDKS
560 570 580 590 600
HRNYTESFFE SASMMSQLSH KHLLLNYGIC VCADEHIMVQ EYVRFGSLDT
610 620 630 640 650
YLKRNRNTIN ITWKLEVAKQ LAWALHHLEE KSLTHGNVCA RNVLVTREED
660 670 680 690 700
RKTGTPPFIK LSDPGISITV QPREILLERI PWVPPECVKD SRNLSLAADK
710 720 730 740 750
WSFGTTLWEI YCGGEQPLAA YDTAKKLLFY EDKHQLPAPK WTELASVINS
760 770 780 790 800
CMDYEPLHRP SFRALIRDLN SLYTPDYELL VESDTVPSRH RGPGLAGAFE
810 820 830 840 850
SQEPTQFQAR HLIFLQLLGK GNFGSVEKCR YDPLQDNTGE VVAVKKLQHS
860 870 880 890 900
TAEHLRDFER EIEILRSLQH ENIVRYKGVC YSAGRNNLRL VMEFLPFGSL
910 920 930 940 950
RDYLSKNRER FDHSKLLLYA SQICKGMDYL AEKRYVHRDL ATRNILVESE
960 970 980 990 1000
FRVKIGDFGL TKVLPQDKEY YTVREPGESP IFWYAPESLT ESKFSVASDV
1010 1020 1030 1040 1050
WSFGVVLYEL FTYSEKSCSP PAVFMEQMGE DKQGQMIVYH LIDLLKRNYR
1060 1070 1080 1090
LPAPDGCPAE IHALMKQCWA PEPADRPLFR DLARTVEDIQ DSQSG
Length:1,095
Mass (Da):125,172
Last modified:November 1, 1998 - v1
Checksum:i61A89BAACED565B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC162596 mRNA. Translation: AAI62596.1.
AJ005690 mRNA. Translation: CAA06674.1.
RefSeqiNP_571168.1. NM_131093.1.
UniGeneiDr.4151.

Genome annotation databases

GeneIDi30307.
KEGGidre:30307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC162596 mRNA. Translation: AAI62596.1.
AJ005690 mRNA. Translation: CAA06674.1.
RefSeqiNP_571168.1. NM_131093.1.
UniGeneiDr.4151.

3D structure databases

SMRiO93596. Positions 803-1095.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000107572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30307.
KEGGidre:30307.

Organism-specific databases

CTDi30307.
ZFINiZDB-GENE-980526-481. jak2a.

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000049158.
HOVERGENiHBG006195.
KOiK04447.
PhylomeDBiO93596.

Enzyme and pathway databases

BRENDAi2.7.10.2. 928.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR019749. Band_41_domain.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016251. Tyr_kinase_non-rcpt_Jak/Tyk2.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 2 hits.
PF00017. SH2. 1 hit.
[Graphical view]
PIRSFiPIRSF000636. TyrPK_Jak. 1 hit.
PRINTSiPR01823. JANUSKINASE.
PR00109. TYRKINASE.
SMARTiSM00295. B41. 1 hit.
SM00252. SH2. 1 hit.
SM00219. TyrKc. 2 hits.
[Graphical view]
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 2 hits.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO93596_DANRE
AccessioniPrimary (citable) accession number: O93596
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.