Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O93593 (MTA_CHAAC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length60 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Domain

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similarities

Belongs to the metallothionein superfamily. Type 1 family.

Ontologies

Keywords
   LigandMetal-binding
Metal-thiolate cluster
Zinc
Gene Ontology (GO)
   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6060Metallothionein A
PRO_0000197273

Regions

Region1 – 2828Beta
Region29 – 6032Alpha

Sites

Metal binding41Divalent metal cation; cluster B By similarity
Metal binding61Divalent metal cation; cluster B By similarity
Metal binding121Divalent metal cation; cluster B By similarity
Metal binding141Divalent metal cation; cluster B By similarity
Metal binding181Divalent metal cation; cluster B By similarity
Metal binding201Divalent metal cation; cluster B By similarity
Metal binding231Divalent metal cation; cluster B By similarity
Metal binding251Divalent metal cation; cluster B By similarity
Metal binding281Divalent metal cation; cluster B By similarity
Metal binding321Divalent metal cation; cluster A By similarity
Metal binding331Divalent metal cation; cluster A By similarity
Metal binding351Divalent metal cation; cluster A By similarity
Metal binding361Divalent metal cation; cluster A By similarity
Metal binding401Divalent metal cation; cluster A By similarity
Metal binding431Divalent metal cation; cluster A By similarity
Metal binding471Divalent metal cation; cluster A By similarity
Metal binding491Divalent metal cation; cluster A By similarity
Metal binding541Divalent metal cation; cluster A By similarity
Metal binding581Divalent metal cation; cluster A By similarity
Metal binding591Divalent metal cation; cluster A By similarity

Sequences

Sequence LengthMass (Da)Tools
O93593 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: E8773344264C424A

FASTA606,017
        10         20         30         40         50         60 
MDPCECSKSG NCNCGGSCTC TNCSCKSCKK SCCPCCPSGC TKCASGCVCI GKTCDTSCCQ 

« Hide

References

[1]"Metallothioneins in antarctic fish: evidence for independent duplication and gene conversion."
Bargelloni L., Scudiero R., Parisi E., Carginale V., Capasso C., Patarnello T.
Mol. Biol. Evol. 16:885-897(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ011583 mRNA. Translation: CAA09713.1.

3D structure databases

ProteinModelPortalO93593.
SMRO93593. Positions 2-29, 31-60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D4.10.10.10. 1 hit.
InterProIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERPTHR23299. PTHR23299. 1 hit.
PfamPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSPR00860. MTVERTEBRATE.
SUPFAMSSF57868. SSF57868. 1 hit.
PROSITEPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTA_CHAAC
AccessionPrimary (citable) accession number: O93593
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Metallothioneins

Classification of metallothioneins and list of entries