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O93593

- MTA_CHAAC

UniProt

O93593 - MTA_CHAAC

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Protein
Metallothionein A
Gene
mta
Organism
Chaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi4 – 41Divalent metal cation; cluster B By similarity
Metal bindingi6 – 61Divalent metal cation; cluster B By similarity
Metal bindingi12 – 121Divalent metal cation; cluster B By similarity
Metal bindingi14 – 141Divalent metal cation; cluster B By similarity
Metal bindingi18 – 181Divalent metal cation; cluster B By similarity
Metal bindingi20 – 201Divalent metal cation; cluster B By similarity
Metal bindingi23 – 231Divalent metal cation; cluster B By similarity
Metal bindingi25 – 251Divalent metal cation; cluster B By similarity
Metal bindingi28 – 281Divalent metal cation; cluster B By similarity
Metal bindingi32 – 321Divalent metal cation; cluster A By similarity
Metal bindingi33 – 331Divalent metal cation; cluster A By similarity
Metal bindingi35 – 351Divalent metal cation; cluster A By similarity
Metal bindingi36 – 361Divalent metal cation; cluster A By similarity
Metal bindingi40 – 401Divalent metal cation; cluster A By similarity
Metal bindingi43 – 431Divalent metal cation; cluster A By similarity
Metal bindingi47 – 471Divalent metal cation; cluster A By similarity
Metal bindingi49 – 491Divalent metal cation; cluster A By similarity
Metal bindingi54 – 541Divalent metal cation; cluster A By similarity
Metal bindingi58 – 581Divalent metal cation; cluster A By similarity
Metal bindingi59 – 591Divalent metal cation; cluster A By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein A
Short name:
MT-A
Gene namesi
Name:mta
OrganismiChaenocephalus aceratus (Blackfin icefish) (Chaenichthys aceratus)
Taxonomic identifieri36190 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaPerciformesNotothenioideiChannichthyidaeChaenocephalus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6060Metallothionein A
PRO_0000197273Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO93593.
SMRiO93593. Positions 2-29, 31-60.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828Beta
Add
BLAST
Regioni29 – 6032Alpha
Add
BLAST

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Family and domain databases

Gene3Di4.10.10.10. 1 hit.
InterProiIPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view]
PANTHERiPTHR23299. PTHR23299. 1 hit.
PfamiPF00131. Metallothio. 1 hit.
[Graphical view]
PRINTSiPR00860. MTVERTEBRATE.
SUPFAMiSSF57868. SSF57868. 1 hit.
PROSITEiPS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93593-1 [UniParc]FASTAAdd to Basket

« Hide

MDPCECSKSG NCNCGGSCTC TNCSCKSCKK SCCPCCPSGC TKCASGCVCI   50
GKTCDTSCCQ 60
Length:60
Mass (Da):6,017
Last modified:November 1, 1998 - v1
Checksum:iE8773344264C424A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011583 mRNA. Translation: CAA09713.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ011583 mRNA. Translation: CAA09713.1 .

3D structure databases

ProteinModelPortali O93593.
SMRi O93593. Positions 2-29, 31-60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 4.10.10.10. 1 hit.
InterProi IPR017854. Metalthion_dom.
IPR023587. Metalthion_dom_vert.
IPR003019. Metalthion_sfam_euk.
IPR000006. Metalthion_vert.
IPR018064. Metalthion_vert_metal_BS.
[Graphical view ]
PANTHERi PTHR23299. PTHR23299. 1 hit.
Pfami PF00131. Metallothio. 1 hit.
[Graphical view ]
PRINTSi PR00860. MTVERTEBRATE.
SUPFAMi SSF57868. SSF57868. 1 hit.
PROSITEi PS00203. METALLOTHIONEIN_VRT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metallothioneins in antarctic fish: evidence for independent duplication and gene conversion."
    Bargelloni L., Scudiero R., Parisi E., Carginale V., Capasso C., Patarnello T.
    Mol. Biol. Evol. 16:885-897(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiMTA_CHAAC
AccessioniPrimary (citable) accession number: O93593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1998
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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