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Protein

Homeobox protein zampogna

Gene

zax

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi100 – 15960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein zampogna
Alternative name(s):
Xzax
Gene namesi
Name:zax1 Publication
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865322. nkx3-3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Homeobox protein zampognaPRO_0000271784Add
BLAST

Expressioni

Tissue specificityi

At early tailbud stage, expressed in the pharyngeal endoderm, concentrated within the pharyngeal clefts. Also expressed in the mesenchymal head cells in the future infrarostral cartilage. Beginning at the mid-tailbud stage, expressed in the muscular layer of the midgut.1 Publication

Developmental stagei

Expressed at a low level throughout all developmental stages. Expression levels significantly increase after the mid-tailbud stage and are maintained through the tadpole stage (stage 40).1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93590.
SMRiO93590. Positions 93-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-3 homeobox family.Sequence analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG006689.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTSFSIQD ILARTGGNRG KDTRTDGNNI SPPPSPSADE GHNEWPRAEN
60 70 80 90 100
PPLTPEKEKT DTDSGTEDFH WERDTETANN GAFTDPSSGD RLADSPKSSK
110 120 130 140 150
KRSRAAFSHA QVYELERRFS LQRYLSGPER ADLAASLKLT ETQVKIWFQN
160 170 180 190 200
RRYKTKRKLI ATQTAPKSSL VPTRKVAVRV LVKDDQRQYC PEDMLSPSLL
210 220
SLYHAYQYYP YMYCLPAWVP HLPL
Length:224
Mass (Da):25,463
Last modified:November 1, 1998 - v1
Checksum:i18DA70F447C2294C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095721 mRNA. Translation: AAC64197.1.
RefSeqiNP_001079154.1. NM_001085685.1.
UniGeneiXl.405.

Genome annotation databases

GeneIDi373704.
KEGGixla:373704.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095721 mRNA. Translation: AAC64197.1.
RefSeqiNP_001079154.1. NM_001085685.1.
UniGeneiXl.405.

3D structure databases

ProteinModelPortaliO93590.
SMRiO93590. Positions 93-157.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373704.
KEGGixla:373704.

Organism-specific databases

CTDi373704.
XenbaseiXB-GENE-865322. nkx3-3.

Phylogenomic databases

HOVERGENiHBG006689.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The Xenopus bagpipe-related homeobox gene zampogna is expressed in the pharyngeal endoderm and the visceral musculature of the midgut."
    Newman C.S., Krieg P.A.
    Dev. Genes Evol. 209:132-134(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Tadpole1 Publication.

Entry informationi

Entry nameiZAX_XENLA
AccessioniPrimary (citable) accession number: O93590
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Based on similarity to Drosophila 'bagpipe/bap', the name 'zampogna' was chosen after an Italian musical instrument related to the Scottish bagpipe.1 Publication

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.