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Protein

Homeobox protein zampogna

Gene

zax

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Based on similarity to Drosophila 'bagpipe/bap', the name 'zampogna' was chosen after an Italian musical instrument related to the Scottish bagpipe.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi100 – 159HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein zampogna
Alternative name(s):
Xzax
Gene namesi
Name:zax1 Publication
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865322 nkx3-3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002717841 – 224Homeobox protein zampognaAdd BLAST224

Expressioni

Tissue specificityi

At early tailbud stage, expressed in the pharyngeal endoderm, concentrated within the pharyngeal clefts. Also expressed in the mesenchymal head cells in the future infrarostral cartilage. Beginning at the mid-tailbud stage, expressed in the muscular layer of the midgut.1 Publication

Developmental stagei

Expressed at a low level throughout all developmental stages. Expression levels significantly increase after the mid-tailbud stage and are maintained through the tadpole stage (stage 40).1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93590
SMRiO93590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NK-3 homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG006689
KOiK09995

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O93590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLTSFSIQD ILARTGGNRG KDTRTDGNNI SPPPSPSADE GHNEWPRAEN
60 70 80 90 100
PPLTPEKEKT DTDSGTEDFH WERDTETANN GAFTDPSSGD RLADSPKSSK
110 120 130 140 150
KRSRAAFSHA QVYELERRFS LQRYLSGPER ADLAASLKLT ETQVKIWFQN
160 170 180 190 200
RRYKTKRKLI ATQTAPKSSL VPTRKVAVRV LVKDDQRQYC PEDMLSPSLL
210 220
SLYHAYQYYP YMYCLPAWVP HLPL
Length:224
Mass (Da):25,463
Last modified:November 1, 1998 - v1
Checksum:i18DA70F447C2294C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF095721 mRNA Translation: AAC64197.1
RefSeqiNP_001079154.1, NM_001085685.1
UniGeneiXl.405

Genome annotation databases

GeneIDi373704
KEGGixla:373704

Similar proteinsi

Entry informationi

Entry nameiZAX_XENLA
AccessioniPrimary (citable) accession number: O93590
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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