Fibrinogen gamma chain precursor - Gallus gallus (Chicken)

Preferred order of sections

Names and origin

Protein names	Submitted name: Fibrinogen gamma chain EMBL AAC36476.1
Organism	Gallus gallus (Chicken) EMBL AAC36476.1
Taxonomic identifier	9031 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 fibrinogen C-terminal domain. SAAS SAAS014715

Ontologies

Keywords
Domain	Signal EMBL AAC36476.1
Ligand	Calcium PDB 1M1J Metal-binding PDB 1M1J
PTM	Disulfide bond SAAS SAAS014715
Technical term	3D-structure PDB 1EI3 PDB 1M1J
Gene Ontology (GO)
Biological process	platelet activation Inferred from electronic annotation. Source: InterPro protein polymerization Inferred from electronic annotation. Source: InterPro signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	fibrinogen complex Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding, bridging Inferred from electronic annotation. Source: InterPro receptor binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

26

Potential EMBL AAC36476.1

Chain

27 – 435

409

fibrinogen gamma chain EMBL AAC36476.1

PRO_5000055073

Sites

Metal binding

344

1

Calcium PDB 1M1J

Metal binding

346

1

Calcium PDB 1M1J

Metal binding

348

1

Calcium; via carbonyl oxygen PDB 1M1J

Metal binding

350

1

Calcium; via carbonyl oxygen PDB 1M1J

Sequences

Sequence

Length

Mass (Da)

Tools

O93568 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 91D2BC7FE86E0766
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FASTA

435

49,642

        10         20         30         40         50         60 
MMGVKSVTSR LAVGDLLSLL FSTSMAYIAT RENCCILDER FGSYCPTTCG IADFFNKYRL 

        70         80         90        100        110        120 
TTDGELLEIE GLLQQATNST GSIEYLIQHI KTIYPSEKQT LPQSIEQLTQ KSKKIIEEII 

       130        140        150        160        170        180 
RYENTILAHE NTIQQLTDMH IMNSNKITQL KQKIAQLESH CQEPCKDTAE IQETTGRDCQ 

       190        200        210        220        230        240 
DIANKGARKS GLYFIKPQKA KQSFLVYCEI DTYGNGWTVL QRRLDGSEDF RRNWVQYKEG 

       250        260        270        280        290        300 
FGHLSPDDTT EFWLGNEKIH LITTQSTLPY ALRIELEDWS GKKGTADYAV FKVGTEEDKY 

       310        320        330        340        350        360 
RLTYAYFIGG ERGDAFDGFN FGDDPSDKSY TYHNGMRFST FDNDNDNFEG NCAEQDGSGW 

       370        380        390        400        410        420 
WMNRCHAGHL NGPYYIGGVY SRDTGTNSYD NGIIWATWRD RWYSMKKTTM KIIPFNRLSI 

       430 
DGQQHSGGLK QVGDS

« Hide

References

[1]	"Chicken fibrinogen gamma chain mRNA." Cao Y., Weissbach L., Fu Y., Grieninger G. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: White Leghorn EMBL AAC36476.1. Tissue: Liver EMBL AAC36476.1.
[2]	"Crystal structure of native chicken fibrinogen at 5.5-A resolution." Yang Z., Mochalkin I., Veerapandian L., Riley M., Doolittle R.F. Proc. Natl. Acad. Sci. U.S.A. 97:3907-3912(2000) [PubMed: 10737772] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (5.50 ANGSTROMS) OF 27-435.
[3]	"Crystal structure of native chicken fibrinogen at 2.7 A resolution." Yang Z., Kollman J.M., Pandi L., Doolittle R.F. Biochemistry 40:12515-12523(2001) [PubMed: 11601975] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 27-435 IN COMPLEX WITH CALCIUM.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF087432 mRNA. Translation: AAC36476.1.

IPI

IPI00685084.

RefSeq

NP_990320.1. NM_204989.1.

UniGene

Gga.1165.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EI3	X-ray	5.50	C/F	27-435	[»]
1M1J	X-ray	2.70	C/F	27-435	[»]

ProteinModelPortal

O93568.

SMR

O93568. Positions 30-419.

ModBase

Search...

Protein-protein interaction databases

STRING

O93568.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

395837.

KEGG

gga:395837.

Organism-specific databases

CTD

2266.

Phylogenomic databases

eggNOG

veNOG07570.

GeneTree

ENSGT00600000084261.

HOGENOM

HBG506654.

HOVERGEN

HBG099783.

InParanoid

O93568.

Family and domain databases

InterPro

IPR002181. Fibrinogen_a/b/g_C.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]

Gene3D

G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
G3DSA:4.10.530.10. Fibrinogen_a/b/g_C_2. 1 hit.
G3DSA:1.20.5.50. Fibrinogen_a/b/g_coil. 1 hit.

KO

K03905.

Pfam

PF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]

SMART

SM00186. FBG. 1 hit.
[Graphical view]

SUPFAM

SSF56496. Fibrinogen_a/b/g_C. 1 hit.

PROSITE

PS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

O93568_CHICK

Accession

Primary (citable) accession number: O93568

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	November 1, 1998
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)