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Protein

Zinc finger and BTB domain-containing protein 7A

Gene

ZBTB7A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri359 – 38123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46725C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 7A
Alternative name(s):
Leukemia/lymphoma-related factor
Short name:
cLRF
Gene namesi
Name:ZBTB7A
Synonyms:LRF, ZBTB7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Zinc finger and BTB domain-containing protein 7APRO_0000047718Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiO93567. baseline.

Interactioni

Subunit structurei

Interacts with BCL6.By similarity

Structurei

3D structure databases

ProteinModelPortaliO93567.
SMRiO93567. Positions 7-129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 10168BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi230 – 2334Poly-Glu
Compositional biasi234 – 2374Poly-Ala

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri359 – 38123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri387 – 40923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri415 – 43723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri443 – 46725C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG106747.
InParanoidiO93567.
KOiK10494.
PhylomeDBiO93567.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGVDGPIG IPFPDHSSDI LSSLNEQRNN GLLCDVVILV EGQEFPTHRS
60 70 80 90 100
VLAACSQYFK KLFTSGLVVD QQNVYEIDFV SADALSALLE FAYTATLTVS
110 120 130 140 150
TSNVNDILNA AKLLEIPAVR DVCTDLLDRK ILAKNDQMDL VDQIDQRNHL
160 170 180 190 200
RAKEYLEFFQ SNPVNGHQGS FPWTNPELRD LQRLNFRGQE DEEEPDCNGL
210 220 230 240 250
DFYSQAPLNE RPKANDCDPD SNPAMWLDRE EEEAAAAPGS LFSPSQNGHY
260 270 280 290 300
SGRGLGTPGE EEGAPGAALD QQDAGDSPSF VPTGAEAEDD ARDVDGLAAS
310 320 330 340 350
VLQQVMGSVG RQQLGDDERK DDDGVVDYYL KYFGSSNESD VYPSWSQKVE
360 370 380 390 400
KKIRAKAFQK CPICAKVIQG AGKLPRHIRT HTGEKPYECN ICNVRFTRQD
410 420 430 440 450
KLKVHMRKHT GEKPYLCQQC GAAFAHNYDL KNHMRVHTGL RPYQCDSCFK
460 470 480 490 500
TFVRSDHLHR HLKKDGCNGI PSRRGRRPRV RDAGGLPTPT GNPEDGGFQG
510 520 530 540
GGESQESEDT VQGNGREQHF EESSTAEAAG LNVAGGAAEG SAPGPS
Length:546
Mass (Da):59,842
Last modified:November 1, 1998 - v1
Checksum:i8E3DDC652E1876C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086831 mRNA. Translation: AAC35368.1.
RefSeqiNP_990011.1. NM_204680.1.
UniGeneiGga.222.

Genome annotation databases

GeneIDi395411.
KEGGigga:395411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF086831 mRNA. Translation: AAC35368.1.
RefSeqiNP_990011.1. NM_204680.1.
UniGeneiGga.222.

3D structure databases

ProteinModelPortaliO93567.
SMRiO93567. Positions 7-129.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395411.
KEGGigga:395411.

Organism-specific databases

CTDi51341.

Phylogenomic databases

HOVERGENiHBG106747.
InParanoidiO93567.
KOiK10494.
PhylomeDBiO93567.

Miscellaneous databases

NextBioi20815495.
PROiO93567.

Gene expression databases

ExpressionAtlasiO93567. baseline.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene."
    Davies J.M., Hawe N., Kabarowski J., Huang Q.-H., Zhu J., Brand N.J., Leprince D., Dhordain P., Cook M., Moriss-Kay G., Zelent A.
    Oncogene 18:365-375(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiZBT7A_CHICK
AccessioniPrimary (citable) accession number: O93567
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.