Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction beta-6 protein

Gene

GJB6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationCurated

GO - Biological processi

Keywordsi

Biological processHearing

Enzyme and pathway databases

ReactomeiR-GGA-190872 Transport of connexons to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:GJB6
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 75ExtracellularSequence analysisAdd BLAST35
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 137CytoplasmicSequence analysisAdd BLAST41
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 189ExtracellularSequence analysisAdd BLAST31
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 263CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000578731 – 263Gap junction beta-6 proteinAdd BLAST263

Proteomic databases

PaxDbiO93533

Expressioni

Tissue specificityi

Exclusively expressed in the cochlea of the inner ear, where it is found in cells of the tegmentum vasculosum, cuboidal cells, supporting cells and clear cells.1 Publication

Developmental stagei

Specifically expressed at the late developmental stages in the cochlea.1 Publication

Gene expression databases

BgeeiENSGALG00000017136

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationCurated

Structurei

3D structure databases

SMRiO93533
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8 Eukaryota
ENOG410Y7VN LUCA
GeneTreeiENSGT00910000144026
HOGENOMiHOG000231127
HOVERGENiHBG009576
InParanoidiO93533
KOiK07625
OMAiVMYDGFA
OrthoDBiEOG091G0FKH
PhylomeDBiO93533
TreeFamiTF329606

Family and domain databases

Gene3Di1.20.1440.80, 1 hit
InterProiView protein in InterPro
IPR000500 Connexin
IPR019570 Connexin_CCC
IPR017990 Connexin_CS
IPR013092 Connexin_N
IPR038359 Connexin_N_sf
PANTHERiPTHR11984 PTHR11984, 1 hit
PfamiView protein in Pfam
PF00029 Connexin, 1 hit
PRINTSiPR00206 CONNEXIN
SMARTiView protein in SMART
SM00037 CNX, 1 hit
SM01089 Connexin_CCC, 1 hit
PROSITEiView protein in PROSITE
PS00407 CONNEXINS_1, 1 hit
PS00408 CONNEXINS_2, 1 hit

Sequencei

Sequence statusi: Complete.

O93533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA ERVWGDEQDD
60 70 80 90 100
FICNTLQPGC KNVCYDHFFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRQFRKGD QKCEYKDIEE IRTQRFRIEG TLWWTYTCSI FFRLVFEAVF
160 170 180 190 200
MYAFYFMYDG FRMPRLMKCS AWPCPNTVDC FVSRPTEKTV FTIFMIAVSS
210 220 230 240 250
ICILLNVAEL CYLLTKFFLR RSRKAGNQKH HPNHENKEET KQNEMNELIS
260
DSCQNTVIGF TSS
Length:263
Mass (Da):30,923
Last modified:November 1, 1998 - v1
Checksum:iD809506A6DB628BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072699 mRNA Translation: AAC64043.1
RefSeqiNP_990262.1, NM_204931.1
XP_015133175.1, XM_015277689.1
XP_015133180.1, XM_015277694.1
XP_015133186.1, XM_015277700.1
UniGeneiGga.1951

Genome annotation databases

EnsembliENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136
GeneIDi395771
KEGGigga:395771

Similar proteinsi

Entry informationi

Entry nameiCXB6_CHICK
AccessioniPrimary (citable) accession number: O93533
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health