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Protein

Gap junction beta-6 protein

Gene

GJB6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.UniRule annotationCurated

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Hearing

Enzyme and pathway databases

ReactomeiR-GGA-190872. Transport of connexons to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction beta-6 protein
Alternative name(s):
Connexin-31
Short name:
Cx31
Gene namesi
Name:GJB6
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence analysisAdd
BLAST
Transmembranei20 – 4021HelicalSequence analysisAdd
BLAST
Topological domaini41 – 7535ExtracellularSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 13741CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 18931ExtracellularSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Topological domaini211 – 26353CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Gap junction beta-6 proteinPRO_0000057873Add
BLAST

Proteomic databases

PaxDbiO93533.

Expressioni

Tissue specificityi

Exclusively expressed in the cochlea of the inner ear, where it is found in cells of the tegmentum vasculosum, cuboidal cells, supporting cells and clear cells.1 Publication

Developmental stagei

Specifically expressed at the late developmental stages in the cochlea.1 Publication

Gene expression databases

BgeeiENSGALG00000017136.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.UniRule annotationCurated

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027628.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiO93533.
KOiK07625.
OMAiVMYDGFA.
OrthoDBiEOG091G0FKH.
PhylomeDBiO93533.
TreeFamiTF329606.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWGALQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA ERVWGDEQDD
60 70 80 90 100
FICNTLQPGC KNVCYDHFFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH
110 120 130 140 150
EKKRQFRKGD QKCEYKDIEE IRTQRFRIEG TLWWTYTCSI FFRLVFEAVF
160 170 180 190 200
MYAFYFMYDG FRMPRLMKCS AWPCPNTVDC FVSRPTEKTV FTIFMIAVSS
210 220 230 240 250
ICILLNVAEL CYLLTKFFLR RSRKAGNQKH HPNHENKEET KQNEMNELIS
260
DSCQNTVIGF TSS
Length:263
Mass (Da):30,923
Last modified:November 1, 1998 - v1
Checksum:iD809506A6DB628BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072699 mRNA. Translation: AAC64043.1.
RefSeqiNP_990262.1. NM_204931.1.
XP_015133175.1. XM_015277689.1.
XP_015133180.1. XM_015277694.1.
XP_015133186.1. XM_015277700.1.
UniGeneiGga.1951.

Genome annotation databases

EnsembliENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136.
GeneIDi395771.
KEGGigga:395771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072699 mRNA. Translation: AAC64043.1.
RefSeqiNP_990262.1. NM_204931.1.
XP_015133175.1. XM_015277689.1.
XP_015133180.1. XM_015277694.1.
XP_015133186.1. XM_015277700.1.
UniGeneiGga.1951.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027628.

Proteomic databases

PaxDbiO93533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027681; ENSGALP00000027628; ENSGALG00000017136.
GeneIDi395771.
KEGGigga:395771.

Organism-specific databases

CTDi10804.

Phylogenomic databases

eggNOGiENOG410IFM8. Eukaryota.
ENOG410Y7VN. LUCA.
GeneTreeiENSGT00840000129674.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiO93533.
KOiK07625.
OMAiVMYDGFA.
OrthoDBiEOG091G0FKH.
PhylomeDBiO93533.
TreeFamiTF329606.

Enzyme and pathway databases

ReactomeiR-GGA-190872. Transport of connexons to the plasma membrane.

Miscellaneous databases

PROiO93533.

Gene expression databases

BgeeiENSGALG00000017136.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXB6_CHICK
AccessioniPrimary (citable) accession number: O93533
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1998
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.