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Protein

Keratin, type II cytoskeletal cochleal

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal cochleal
Alternative name(s):
Cytokeratin otokeratin
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Keratin, type II cytoskeletal cochlealPRO_0000063746Add
BLAST

Proteomic databases

PRIDEiO93532.

Expressioni

Tissue specificityi

Abundant in the cochlea of the inner ear, where it is found in the cells of the tegmentum vasculosum. Lower levels also found in the heart and forebrain.1 Publication

Developmental stagei

Specifically expressed at the late developmental stages in the cochlea.1 Publication

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.By similarity

Structurei

3D structure databases

ProteinModelPortaliO93532.
SMRiO93532. Positions 113-149.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 113113HeadAdd
BLAST
Regioni114 – 421308RodAdd
BLAST
Regioni114 – 14936Coil 1AAdd
BLAST
Regioni150 – 16617Linker 1Add
BLAST
Regioni167 – 25993Coil 1BAdd
BLAST
Regioni260 – 28223Linker 12Add
BLAST
Regioni283 – 421139Coil 2Add
BLAST
Regioni422 – 49271TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000230976.
HOVERGENiHBG013015.
KOiK07605.
PhylomeDBiO93532.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93532-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSVSFSSR SVAVPGVSQV RVSSVSSVRG GGSLNKAGGF GSSSLYNLGS
60 70 80 90 100
ANKRISLGGS SSYSVRSGYG YGGMGFGGAI APSAGIQEVT VNQNLLTPLN
110 120 130 140 150
LEIDPNIQRV RKEEKEQIKT LNNRFASFID KVRFLEQQNK MLETKWSLLQ
160 170 180 190 200
DQKTTRSNIV PMFEAYITNL RRQLDGLLND KGRLEGELRN MQDLVEDFKA
210 220 230 240 250
KYEDEINKRT TAENEFVVLK KDVDAAYMNK VELEAKVDAL TDEINFLRSL
260 270 280 290 300
YEAELRELQA QISDTSVVLS MDNSRNLDLD SIIAEVKAQY EDIANRSRAE
310 320 330 340 350
AESWYQSKFE ALQVTAGKHG DDLRNTKNEI TEINRVIQRL QGEIENAKAQ
360 370 380 390 400
RAKMEAAIAE AEERGELAVK DARAKLEELE AALQKAKQDM ARQLREYQEL
410 420 430 440 450
MNVKLALDIE IATYRKLLEG EESRLAGDGV GSVNISMVSS SGGGSSGFLG
460 470 480 490
GGVRGGLALG AGMGSGALGF SSGGSTKSYT VTTTSSTRSF RK
Length:492
Mass (Da):53,803
Last modified:November 1, 1998 - v1
Checksum:iA01A66426B9F3941
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072698 mRNA. Translation: AAC64042.1.
PIRiA60093.
RefSeqiNP_990263.1. NM_204932.1.
UniGeneiGga.9481.

Genome annotation databases

GeneIDi395772.
KEGGigga:395772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF072698 mRNA. Translation: AAC64042.1.
PIRiA60093.
RefSeqiNP_990263.1. NM_204932.1.
UniGeneiGga.9481.

3D structure databases

ProteinModelPortaliO93532.
SMRiO93532. Positions 113-149.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93532.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395772.
KEGGigga:395772.

Organism-specific databases

CTDi3855.

Phylogenomic databases

HOGENOMiHOG000230976.
HOVERGENiHBG013015.
KOiK07605.
PhylomeDBiO93532.

Miscellaneous databases

PROiO93532.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular markers for cell types of the inner ear and candidate genes for hearing disorders."
    Heller S., Sheane C.A., Javed Z., Hudspeth A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: White leghorn.
    Tissue: Basilar papilla.

Entry informationi

Entry nameiK2CO_CHICK
AccessioniPrimary (citable) accession number: O93532
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.