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Protein

Forkhead box protein B1

Gene

foxb1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable transcription factor. May be involved in the early anteroposterior patterning of the neuroectoderm.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi13 – 10795Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein B1
Short name:
FoxB1
Alternative name(s):
Transcription factor FKH-5
Gene namesi
Name:foxb11 Publication
Synonyms:fkh51 Publication
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1018260. foxb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Forkhead box protein B1PRO_0000257998Add
BLAST

Proteomic databases

PRIDEiO93529.

Expressioni

Tissue specificityi

In early gastrulae, expressed in the inner layer of the posterior dorsal ectoderm and in non-involuted mesoderm. By the mid-gastrula stage, expressed solely in the posterior ectoderm. At the end of gastrulation, expressed in ectodermal regions fated to become diencephalon, midbrain and hindbrain, and weakly expressed in regions fated to become spinal cord and tailbud. At the neurula stage, expressed in the midbrain and posterior forebrain (diencephalon) but not in the more anterior forebrain (telencephalon). Also expressed posteriorly in rhombomere 5. At tailbud stages, expression remains in the anterior brain and is also detectable along the length of the central nervous system and in the tailbud.1 Publication

Developmental stagei

Expression begins in early gastrula stage embryos, peaks at the mid-gastrula stage and remains detectable until late tailbud.1 Publication

Inductioni

By FGF signaling.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93529.
SMRiO93529. Positions 13-103.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG102104.
KOiK09395.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPGRNTYS DQKPPYSYIS LTAMAIQGSQ EKMLPLSEIY KFIMDRFPYY
60 70 80 90 100
RENTQRWQNS LRHNLSFNDC FIKIPRRPDQ PGKGSFWALH PRCGDMFENG
110 120 130 140 150
SFLRRRKRFK VMKSDHLAPS KASDAAQYLQ QQAKLRLSAL AASGTHLPPM
160 170 180 190 200
STYNLGVSPT SSFKHPFAIE NIIAREYKMP GGLAFSTMQP MPAAYPLHNQ
210 220 230 240 250
LTTVGGSIGT GWPHMYSSSM LDSTTPISMA NSDYSVSAYG VPIKPICHGA
260 270 280 290 300
QTLLPAIPVP IKPTAALPAL PTHIPAILSN SSPSMSPTSP QTATSQSSPA
310
TPSDTLTNPS TALLSVAVH
Length:319
Mass (Da):34,954
Last modified:November 1, 1998 - v1
Checksum:i80F3ACD975929D86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064810 mRNA. Translation: AAC62623.1.
BC124883 mRNA. Translation: AAI24884.1.
RefSeqiNP_001081836.1. NM_001088367.1.
UniGeneiXl.403.

Genome annotation databases

GeneIDi398078.
KEGGixla:398078.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064810 mRNA. Translation: AAC62623.1.
BC124883 mRNA. Translation: AAI24884.1.
RefSeqiNP_001081836.1. NM_001088367.1.
UniGeneiXl.403.

3D structure databases

ProteinModelPortaliO93529.
SMRiO93529. Positions 13-103.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93529.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398078.
KEGGixla:398078.

Organism-specific databases

CTDi27023.
XenbaseiXB-GENE-1018260. foxb1.

Phylogenomic databases

HOVERGENiHBG102104.
KOiK09395.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Early anteroposterior division of the presumptive neurectoderm in Xenopus."
    Gamse J.T., Sive H.
    Mech. Dev. 104:21-36(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION.
    Tissue: Ectoderm1 Publication and Gastrula1 Publication.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  3. "Of fox and frogs: fox (fork head/winged helix) transcription factors in Xenopus development."
    Pohl B.S., Knoechel W.
    Gene 344:21-32(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiFOXB1_XENLA
AccessioniPrimary (citable) accession number: O93529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1998
Last modified: March 16, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.