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Protein

Ventral anterior homeobox 1a

Gene

vax1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in the specification and maintenance of basal forebrain identity.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 156HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 1a
Gene namesi
Name:vax1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252856 vax1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002405271 – 295Ventral anterior homeobox 1aAdd BLAST295

Proteomic databases

PRIDEiO93528

Expressioni

Developmental stagei

First detectable at early gastrula stages. Expressed in the anterior-most region of the open neural plate and midanterior and midlateral anterior ridge. By late neurula stages, expressed in the derivatives of these regions namely, in the anterior and rostral ventrolateral part of the forebrain neuroepithelium, primordium striatum, optic stalk, chiasmatic ridge and the anterior hypothalamus. At tailbud stages the expression extends laterally and caudally with the enlargement of the forebrain ventricle. Expression in the tadpole stage embryos is specific to the optic disk, optic stalk and anterior hypothalamus.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93528
SMRiO93528
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG007558
KOiK09318

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR033020 Vax1
PANTHERiPTHR24339:SF32 PTHR24339:SF32, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

O93528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKTTDMDI RCNIEENGRI SKPKDNKEIR ETQAKMPSTY LKEQPGTYPA
60 70 80 90 100
PGSSELCAKN KSSSAGDPEY CRRILVRDAK GSIREIILPK GLDLDRPKRS
110 120 130 140 150
RTSFTAEQLY RLEMEFQRCQ YVVGRERTDL SRQLNLSETQ VKVWFQNRRT
160 170 180 190 200
KQKKDQGKDS ELRSVVSETA ATCSVLRLLE QGRLLSPPGL PGLMPPCTTG
210 220 230 240 250
TLRAPNSSGP GTRSLATVTS TPPHQPGLHP SPTGHNIFNM PVPSLLGTVA
260 270 280 290
NRLSSHPLTM AGNLHELSAR YLSSSAFEPY SRSISKDSLD KKLLD
Length:295
Mass (Da):32,828
Last modified:November 1, 1998 - v1
Checksum:iACAF83506AD6727F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064601 mRNA Translation: AAC35794.1
RefSeqiNP_001079149.1, NM_001085680.1
UniGeneiXl.300

Genome annotation databases

GeneIDi373698
KEGGixla:373698

Similar proteinsi

Entry informationi

Entry nameiVAX1A_XENLA
AccessioniPrimary (citable) accession number: O93528
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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