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Protein

Ventral anterior homeobox 1a

Gene

vax1-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the specification and maintenance of basal forebrain identity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi97 – 15660HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ventral anterior homeobox 1a
Gene namesi
Name:vax1-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252856. vax1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 295295Ventral anterior homeobox 1aPRO_0000240527Add
BLAST

Expressioni

Developmental stagei

First detectable at early gastrula stages. Expressed in the anterior-most region of the open neural plate and midanterior and midlateral anterior ridge. By late neurula stages, expressed in the derivatives of these regions namely, in the anterior and rostral ventrolateral part of the forebrain neuroepithelium, primordium striatum, optic stalk, chiasmatic ridge and the anterior hypothalamus. At tailbud stages the expression extends laterally and caudally with the enlargement of the forebrain ventricle. Expression in the tadpole stage embryos is specific to the optic disk, optic stalk and anterior hypothalamus.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93528.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EMX homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

HOVERGENiHBG007558.
KOiK09318.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR033020. Vax1.
[Graphical view]
PANTHERiPTHR24339:SF32. PTHR24339:SF32. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93528-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFEKTTDMDI RCNIEENGRI SKPKDNKEIR ETQAKMPSTY LKEQPGTYPA
60 70 80 90 100
PGSSELCAKN KSSSAGDPEY CRRILVRDAK GSIREIILPK GLDLDRPKRS
110 120 130 140 150
RTSFTAEQLY RLEMEFQRCQ YVVGRERTDL SRQLNLSETQ VKVWFQNRRT
160 170 180 190 200
KQKKDQGKDS ELRSVVSETA ATCSVLRLLE QGRLLSPPGL PGLMPPCTTG
210 220 230 240 250
TLRAPNSSGP GTRSLATVTS TPPHQPGLHP SPTGHNIFNM PVPSLLGTVA
260 270 280 290
NRLSSHPLTM AGNLHELSAR YLSSSAFEPY SRSISKDSLD KKLLD
Length:295
Mass (Da):32,828
Last modified:November 1, 1998 - v1
Checksum:iACAF83506AD6727F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064601 mRNA. Translation: AAC35794.1.
RefSeqiNP_001079149.1. NM_001085680.1.
UniGeneiXl.300.

Genome annotation databases

GeneIDi373698.
KEGGixla:373698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064601 mRNA. Translation: AAC35794.1.
RefSeqiNP_001079149.1. NM_001085680.1.
UniGeneiXl.300.

3D structure databases

ProteinModelPortaliO93528.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373698.
KEGGixla:373698.

Organism-specific databases

CTDi373698.
XenbaseiXB-GENE-6252856. vax1.

Phylogenomic databases

HOVERGENiHBG007558.
KOiK09318.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR033020. Vax1.
[Graphical view]
PANTHERiPTHR24339:SF32. PTHR24339:SF32. 1 hit.
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Vax1 is a novel homeobox-containing gene expressed in the developing anterior ventral forebrain."
    Hallonet M., Hollemann T., Wehr R., Jenkins N.A., Copeland N.G., Pieler T., Gruss P.
    Development 125:2599-2610(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Head.

Entry informationi

Entry nameiVAX1A_XENLA
AccessioniPrimary (citable) accession number: O93528
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.