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Protein
Submitted name:

Nonmuscle myosin II heavy chain A

Gene

myh9

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, MyosinSAAS annotation

Keywords - Ligandi

Actin-bindingSAAS annotation, ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Nonmuscle myosin II heavy chain AImported
Gene namesi
Name:myh9Imported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1002225. myh9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiO93522.

Structurei

3D structure databases

ProteinModelPortaliO93522.
SMRiO93522. Positions 4-806.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 776696Myosin motorInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili868 – 1014147Sequence analysisAdd
BLAST
Coiled coili1022 – 1154133Sequence analysisAdd
BLAST
Coiled coili1173 – 126088Sequence analysisAdd
BLAST
Coiled coili1303 – 137270Sequence analysisAdd
BLAST
Coiled coili1380 – 142849Sequence analysisAdd
BLAST
Coiled coili1457 – 1568112Sequence analysisAdd
BLAST
Coiled coili1577 – 1751175Sequence analysisAdd
BLAST
Coiled coili1759 – 180042Sequence analysisAdd
BLAST
Coiled coili1802 – 184342Sequence analysisAdd
BLAST
Coiled coili1848 – 192073Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.SAAS annotation
Contains IQ domain.SAAS annotation
Contains myosin motor domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG004704.
KOiK10352.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93522-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTDVDKYL YVDRNFVNNP LAQADWAAKK LVWVPSEKNG FEAASIKEEV
60 70 80 90 100
GDEAIVELAE NGKKAKVNKD DIQKMNPPKF SKVEDMSELA CLNEASVLHN
110 120 130 140 150
LKERYYSGLI YTYSGLFCVV INPYKNLPIY SEEIVEMYKG KKRHEMPPHI
160 170 180 190 200
YAITDTAYRS MMQDREDQSI LCTGESGAGK TENTKKVIQY LAYVATSHKS
210 220 230 240 250
KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR INFDVNGYIV
260 270 280 290 300
GANIETYLLE KSRAIRQAKD ERTFHIFYYL MSGAGEHLKS DLLLEAYNKY
310 320 330 340 350
RFLSNGHVTI PGQLDKDLFQ ETMEAMKIMG FTDEEQTGLL RVVSAVLQLG
360 370 380 390 400
NIAFKKERNT DQASMPDNTA AQKVCHLLGI NVNDFTRGIL LPRIKVGRDF
410 420 430 440 450
VQKAQTKEQA DFAIEALAKA SYERMFRWLV MRVNKALDKT KRQGASFIGI
460 470 480 490 500
LDIAGFEIFE LNSFEQLCIN YTNEKLQQLF NHTMFILEQE EYQREGIEWN
510 520 530 540 550
FIDFGLDLQP CIDLIERPAG PPGILALLDE ECWFPKATDK SFVEKVVQEQ
560 570 580 590 600
GSHSKFQKPK QLKDKADFSI IHYAGRVDYK ADEWLLKNMD PLNDNVATLL
610 620 630 640 650
NQSSDKFVSE LWKDVDRIVG LDQVAGMSDT ALPGAFKTRK GMFRTVGQLY
660 670 680 690 700
KEQLSKLMAT LRNTNPNFVR CIIPNHEKKS GKLDAHLVLD QLRCNGVLEG
710 720 730 740 750
IRICRQGFPN RVVFQEFRQR YEILTPNAIP KGFMDGKQAC VLMIRALELD
760 770 780 790 800
SNLYRIGQSK VFFRSGVLAH LEEERDLKIT DVIISFQACC RGYLARKAFA
810 820 830 840 850
RRQQQLTAMK VIQRNCAAYL KLRNWQWWRL FTKVKPLLQA NRFDEELHAK
860 870 880 890 900
EVELQKIKDL QVSSEQKVSE MENVQMMLQQ EKMQLQEQLQ AEIELCAEAE
910 920 930 940 950
EMRARLANKK QELEEILHDL ESRVEEEEER CQILQTEKKK MQQNIVELEE
960 970 980 990 1000
QLEEEEAARQ KLQLEKVTAE AKMKKLEEDV LVLEDQNTKL GKEKKLYEER
1010 1020 1030 1040 1050
IAEFTTNLTE EEEKSKSLAK LKNKHETMIS DLEERLRREE KQRQELEKTR
1060 1070 1080 1090 1100
RKLEGDSTDL HDQIAELQAQ IAELKLQLAK KEEELQAALA RAEEEAAQKN
1110 1120 1130 1140 1150
LALKKIRELE SQIGELQEDL ESERAARNKA EKQKRDLGEE LEALKTELED
1160 1170 1180 1190 1200
TLDSTATQQE LRTKREQEVT HLKKTLEDEA RTHEGQIQEI RQKHSQAVEE
1210 1220 1230 1240 1250
LSEQLEQTKR LKGNLEKAKQ ALEGERNELA NEVKTLLQGK GDSEHKRKKV
1260 1270 1280 1290 1300
EAQLQELQVK VTEGDRVRSE LSEKANRLQV ELDNVNSLLS QSDSKSIKLG
1310 1320 1330 1340 1350
KDFSTLESQF QDAQELLQEE TRQKLSFSTK LKQMEDEKNG LLEQLEEEEE
1360 1370 1380 1390 1400
AKKNLCKQIS TLQSQMTDMK KKMDENVGSL ETVEELKKKL QKDLEAVNQR
1410 1420 1430 1440 1450
FEEKAAAYDK LEKTKTRLQQ ELDDISVDLD HQRQIVSNLE KKQKKFDQLL
1460 1470 1480 1490 1500
GEEKAISAKY ADERDRSEAE AREKETKALA LARALEEALE AKAELERLNK
1510 1520 1530 1540 1550
QLRTEMEDLV SSKDDVGKSV HELEKSKRAL EQQAEEMKTQ LEELEDELQA
1560 1570 1580 1590 1600
TEDAKLRLEV NLQAMKAQFE RDLQGRDEQS EDKKKQLVRQ VKEMEAELED
1610 1620 1630 1640 1650
ERKQRSLAVA ARKKLEMDLK DLEGQIDSSN KNREDAIKQL RKLQAQIKDY
1660 1670 1680 1690 1700
QRELEDTRAS RDDILSQSKE SEKKLKSMEA EMIHMQEELA AAERGKRQAQ
1710 1720 1730 1740 1750
QERDELADEI ANSSGKGALA LEEKRRLESR IAQLEEELEE EQGNTELVND
1760 1770 1780 1790 1800
RLKKSTLQID QLNTDLTAER SNAQKNENAR QQMDRQNKEL KTKLQEMEGI
1810 1820 1830 1840 1850
VKSKFKANIT ALEAKIAQLE EQLDTETKER QNASKQVRRT EKKLKDVLML
1860 1870 1880 1890 1900
VEDERRNSEQ YKDQAEKNNV RMKQLKRQVE EAEEEAQRAN AMRRKLQREL
1910 1920 1930 1940 1950
EDATETAEIM NREVNTLKSK LRRGGGGGGD ITFVTRRVGR KGVDEASDED
1960
LDGKADSGDS KFVD
Length:1,964
Mass (Da):226,810
Last modified:November 1, 1998 - v1
Checksum:iE7FB1559546D2F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055895 mRNA. Translation: AAC83556.1.
PIRiA59282.
RefSeqiNP_001081846.1. NM_001088377.1.
UniGeneiXl.421.

Genome annotation databases

GeneIDi398083.
KEGGixla:398083.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055895 mRNA. Translation: AAC83556.1.
PIRiA59282.
RefSeqiNP_001081846.1. NM_001088377.1.
UniGeneiXl.421.

3D structure databases

ProteinModelPortaliO93522.
SMRiO93522. Positions 4-806.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO93522.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398083.
KEGGixla:398083.

Organism-specific databases

CTDi4627.
XenbaseiXB-GENE-1002225. myh9.

Phylogenomic databases

HOVERGENiHBG004704.
KOiK10352.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 1 hit.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Differential expression of non-muscle myosin heavy chain genes during Xenopus embryogenesis."
    Bhatia-Dey N., Taira M., Conti M.A., Nooruddin H., Adelstein R.S.
    Mech. Dev. 78:33-36(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO93522_XENLA
AccessioniPrimary (citable) accession number: O93522
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.