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Protein

GDNF family receptor alpha-4

Gene

GFRA4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
GDNF family receptor alpha-4
Short name:
GDNF receptor alpha-4
Short name:
GDNFR-alpha-4
Short name:
GFR-alpha-4
Gene namesi
Name:GFRA4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 403384GDNF family receptor alpha-4PRO_0000010799Add
BLAST
Propeptidei404 – 43128Removed in mature formSequence analysisPRO_0000010800Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence analysis
Glycosylationi308 – 3081N-linked (GlcNAc...)Sequence analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence analysis
Lipidationi403 – 4031GPI-anchor amidated serineSequence analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiO93512.
PRIDEiO93512.

Expressioni

Developmental stagei

Expressed in muscle, kidney, brain, stomach and intestine at E6. Levels increase in the brain from E6 to E18, and decrease in muscle and intestine. Levels in the kidney remain constant. From E10, expression also found in heart, lung, skin and liver. Levels in the liver increase dramatically at E18. At E18, highest expression found in kidney and brain. In the embryonic central nervous system, the spinal cord expressed the highest levels. Lower levels found in the medulla oblongata, pons, cerebellum and midbrain, and very low levels in the forebrain.

Interactioni

Protein-protein interaction databases

BioGridi676113. 1 interaction.
STRINGi9031.ENSGALP00000025786.

Structurei

3D structure databases

ProteinModelPortaliO93512.
SMRiO93512. Positions 231-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GDNFR family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
InParanoidiO93512.
PhylomeDBiO93512.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGILYFCTL ILLEGMAEAV SSSRDCLQAG ESCTNDPICS SKFRTLRQCI
60 70 80 90 100
AGNGANKLGP DAKNQCRSTV TALLSSQLYG CKCKRGMKKE KHCLSVYWSI
110 120 130 140 150
HHTLMEGMNV LESSPYEPFI RGFDYVRLAS ITAGSENEVT QVNRCLDAAK
160 170 180 190 200
ACNVDEMCQR LRTEYVSFCI RRLARADTCN RSKCHKALRK FFDRVPPEYT
210 220 230 240 250
HELLFCPCED TACAERRRQT IVPACSYESK EKPNCLAPLD SCRENYVCRS
260 270 280 290 300
RYAEFQFNCQ PSLQTASGCR RDSYAACLLA YTGIIGSPIT PNYIDNSTSS
310 320 330 340 350
IAPWCTCNAS GNRQEECESF LHLFTDNVCL QNAIQAFGNG TYLNAATAPS
360 370 380 390 400
ISPTTQMYKQ ERNANRAAAT LSENIFEHLQ PTKVAGEERL LRGSTRLSSE
410 420 430
TSSPAAPCHQ AASLLQLWLP PTLAVLSHFM M
Length:431
Mass (Da):47,965
Last modified:November 1, 1998 - v1
Checksum:i3EDD945D3CC4E71B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045162 mRNA. Translation: AAC36464.1.
RefSeqiNP_990322.1. NM_204991.1.
UniGeneiGga.494.

Genome annotation databases

GeneIDi395839.
KEGGigga:395839.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF045162 mRNA. Translation: AAC36464.1.
RefSeqiNP_990322.1. NM_204991.1.
UniGeneiGga.494.

3D structure databases

ProteinModelPortaliO93512.
SMRiO93512. Positions 231-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676113. 1 interaction.
STRINGi9031.ENSGALP00000025786.

Proteomic databases

PaxDbiO93512.
PRIDEiO93512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395839.
KEGGigga:395839.

Organism-specific databases

CTDi64096.

Phylogenomic databases

eggNOGiENOG410IU4F. Eukaryota.
ENOG410XPTA. LUCA.
HOGENOMiHOG000008695.
HOVERGENiHBG051725.
InParanoidiO93512.
PhylomeDBiO93512.

Miscellaneous databases

NextBioi20815907.
PROiO93512.

Family and domain databases

InterProiIPR016017. GDNF/GAS1.
IPR003438. GDNF_rcpt.
IPR017372. Glial_neurotroph_fac_rcpt_a1/2.
[Graphical view]
PfamiPF02351. GDNF. 3 hits.
[Graphical view]
PIRSFiPIRSF038071. GDNF_family_receptor_alpha. 1 hit.
PRINTSiPR01316. GDNFRECEPTOR.
SMARTiSM00907. GDNF. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic brain.
  2. "GFRalpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin."
    Enokido Y., de Sauvage F., Hongo J.-A., Ninkina N., Rosenthal A., Buchman V.L., Davies A.M.
    Curr. Biol. 8:1019-1022(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF LIGAND.

Entry informationi

Entry nameiGFRA4_CHICK
AccessioniPrimary (citable) accession number: O93512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: November 1, 1998
Last modified: December 9, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.