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O93510

- GELS_CHICK

UniProt

O93510 - GELS_CHICK

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Protein

Gelsolin

Gene
GSN
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi467 – 4671Calcium 1; via carbonyl oxygen By similarity
Metal bindingi468 – 4681Calcium 1 By similarity
Metal bindingi498 – 4981Calcium 1 By similarity
Metal bindingi547 – 5471Calcium 1; via carbonyl oxygen By similarity
Metal bindingi587 – 5871Calcium 2 By similarity
Metal bindingi587 – 5871Calcium 2; via carbonyl oxygen By similarity
Metal bindingi588 – 5881Calcium 2 By similarity
Metal bindingi610 – 6101Calcium 2 By similarity
Metal bindingi692 – 6921Calcium 3; via carbonyl oxygen By similarity
Metal bindingi693 – 6931Calcium 3 By similarity
Metal bindingi715 – 7151Calcium 3 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. actin filament capping Source: UniProtKB-KW
  2. cilium morphogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Actin capping

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Gelsolin
Alternative name(s):
Actin-depolymerizing factor
Short name:
ADF
Brevin
Homogenin
Gene namesi
Name:GSN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Secreted By similarity. Cytoplasmcytoskeleton By similarity
Note: A cytoplasmic form may also exist By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-SubCell
  3. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 778755GelsolinPRO_0000036392Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi211 ↔ 224 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiO93510.
PRIDEiO93510.

Expressioni

Tissue specificityi

Highly expressed in homogene cells of the basilar papilla. Also detected in subcutaneous layer of the skin.1 Publication

Interactioni

Subunit structurei

Binds to actin and to fibronectin.

Protein-protein interaction databases

BioGridi676048. 1 interaction.
IntActiO93510. 1 interaction.
STRINGi9031.ENSGALP00000002197.

Structurei

3D structure databases

ProteinModelPortaliO93510.
SMRiO93510. Positions 50-776.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati72 – 12251Gelsolin-like 1Add
BLAST
Repeati194 – 23441Gelsolin-like 2Add
BLAST
Repeati310 – 35243Gelsolin-like 3Add
BLAST
Repeati449 – 50052Gelsolin-like 4Add
BLAST
Repeati572 – 61241Gelsolin-like 5Add
BLAST
Repeati675 – 71743Gelsolin-like 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni49 – 172124Actin-severing Reviewed predictionAdd
BLAST
Regioni119 – 1224Actin-actin interfilament contact point
Regioni158 – 1658Polyphosphoinositide binding By similarity
Regioni184 – 1929Polyphosphoinositide binding By similarity
Regioni430 – 778349Actin-binding, Ca-sensitive Reviewed predictionAdd
BLAST

Domaini

Comprises six structurally related domains, in a calcium-free environment, pack together to form a compact globular structure in which the putative actin-binding sequences are not sufficiently exposed to enable binding to occur. Binding calcium may release the connections that join the N- and C-terminal halves of gelsolin, enabling each half to bind actin relatively independently. The severing and capping properties of gelsolin are inhibited by binding polyphosphoinositides.

Sequence similaritiesi

Belongs to the villin/gelsolin family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG304849.
HOGENOMiHOG000233630.
HOVERGENiHBG004183.
InParanoidiO93510.
KOiK05768.
PhylomeDBiO93510.

Family and domain databases

Gene3Di3.40.20.10. 6 hits.
InterProiIPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERiPTHR11977. PTHR11977. 1 hit.
PfamiPF00626. Gelsolin. 6 hits.
[Graphical view]
PRINTSiPR00597. GELSOLIN.
SMARTiSM00262. GEL. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93510-1 [UniParc]FASTAAdd to Basket

« Hide

MGKQGFGYIF LTIFCTMALK LNCVSSVSVA GLGYVVTAAV VLSAVPVSMV    50
EHAEFSKAGK EPGLQIWRIE KFDLVPVPKN LYGDFFTGDS YLVLNTIRQR 100
SGNLQYDLHF WLGDESSQDE RGAAAIFTVQ MDDYLQGKAV QHREVQGHES 150
STFLGYFKSG IKYKAGGVAS GFRHVVPNEV TVQRLLQVKG RRTVRATEVP 200
VSWESFNTGD CFILDLGSNI YQWCGSNSNR QERLKATVLA KGIRDNEKNG 250
RAKVFVSEEG AEREEMLQVL GPKPSLPQGA SDDTKTDTAN RKLAKLYKVS 300
NGAGNMAVSL VADENPFSQA ALNTEDCFIL DHGTDGKIFV WKGRSANSDE 350
RKAALKTATD FIDKMGYPKH TQVQVLPESG ETPLFKQFFK NWRDKDQTEG 400
LGEAYISGHV AKIEKVPFDA ATLHTSRAMA AQHGMEDDGS GKKQIWRIEG 450
SEKVPVDPAT YGQFYGGDSY IILYDYRHAG KQGQIIYTWQ GAHSTQDEIA 500
TSAFLTVQLD EELGGSPVQK RVVQGKEPPH LMSMFGGKPL IVYKGGTSRE 550
GGQTTPAQTR LFQVRSSTSG ATRAVELDPA ASQLNSNDAF VLKTPSAAYL 600
WVGRGSNSAE LSGAQELLKV LGARPVQVSE GREPDNFWVA LGGKAPYRTS 650
PRLKDKKMDA YPPRLFACSN KSGRFTIEEV PGDLTQDDLA TDDVMILDTW 700
DQVFVWIGKD AQEEEKTEAL KSAKRYIETD PASRDKRTPV TLVKQGLEPP 750
TFSGWFLGWD DDYWSVDPLQ RAMADVDV 778
Length:778
Mass (Da):85,832
Last modified:November 1, 1998 - v1
Checksum:i7C8DFB0336B068FD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042795 mRNA. Translation: AAC62928.1.
RefSeqiNP_990265.1. NM_204934.1.
UniGeneiGga.4451.

Genome annotation databases

GeneIDi395774.
KEGGigga:395774.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF042795 mRNA. Translation: AAC62928.1 .
RefSeqi NP_990265.1. NM_204934.1.
UniGenei Gga.4451.

3D structure databases

ProteinModelPortali O93510.
SMRi O93510. Positions 50-776.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 676048. 1 interaction.
IntActi O93510. 1 interaction.
STRINGi 9031.ENSGALP00000002197.

Proteomic databases

PaxDbi O93510.
PRIDEi O93510.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395774.
KEGGi gga:395774.

Organism-specific databases

CTDi 2934.

Phylogenomic databases

eggNOGi NOG304849.
HOGENOMi HOG000233630.
HOVERGENi HBG004183.
InParanoidi O93510.
KOi K05768.
PhylomeDBi O93510.

Miscellaneous databases

NextBioi 20815842.
PROi O93510.

Family and domain databases

Gene3Di 3.40.20.10. 6 hits.
InterProi IPR029006. ADF-H/Gelsolin-like_dom.
IPR007123. Gelsolin-like_dom.
IPR007122. Villin/Gelsolin.
[Graphical view ]
PANTHERi PTHR11977. PTHR11977. 1 hit.
Pfami PF00626. Gelsolin. 6 hits.
[Graphical view ]
PRINTSi PR00597. GELSOLIN.
SMARTi SM00262. GEL. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular markers for cell types of the inner ear and candidate genes for hearing disorders."
    Heller S., Sheane C.A., Javed Z., Hudspeth A.J.
    Proc. Natl. Acad. Sci. U.S.A. 95:11400-11405(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: White leghorn.
    Tissue: Basilar papilla.

Entry informationi

Entry nameiGELS_CHICK
AccessioniPrimary (citable) accession number: O93510
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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