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O93505

- TYRP2_CHICK

UniProt

O93505 - TYRP2_CHICK

Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in regulating eumelanin and phaeomelanin levels.

    Catalytic activityi

    L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi191 – 1911Zinc ABy similarity
    Metal bindingi213 – 2131Zinc ABy similarity
    Metal bindingi222 – 2221Zinc ABy similarity
    Metal bindingi370 – 3701Zinc BBy similarity
    Metal bindingi374 – 3741Zinc BBy similarity
    Metal bindingi397 – 3971Zinc BBy similarity

    GO - Molecular functioni

    1. dopachrome isomerase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. melanin biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Melanin biosynthesis

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00785.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-dopachrome tautomerase (EC:5.3.3.12)
    Short name:
    DCT
    Short name:
    DT
    Alternative name(s):
    L-dopachrome Delta-isomerase
    Tyrosinase-related protein 2
    Short name:
    TRP-2
    Short name:
    TRP2
    Gene namesi
    Name:DCT
    Synonyms:TYRP2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. melanosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 521496L-dopachrome tautomerasePRO_0000035894Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiO93505.

    Expressioni

    Tissue specificityi

    Melanocytes and retinal pigmented epithelium.

    Interactioni

    Subunit structurei

    Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000027266.

    Structurei

    3D structure databases

    ProteinModelPortaliO93505.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 474449Lumenal, melanosomeSequence AnalysisAdd
    BLAST
    Topological domaini496 – 52126CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tyrosinase family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG301916.
    HOGENOMiHOG000118376.
    HOVERGENiHBG003553.
    KOiK01827.
    PhylomeDBiO93505.

    Family and domain databases

    Gene3Di1.10.1280.10. 1 hit.
    InterProiIPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view]
    PfamiPF00264. Tyrosinase. 1 hit.
    [Graphical view]
    PRINTSiPR00092. TYROSINASE.
    SUPFAMiSSF48056. SSF48056. 1 hit.
    PROSITEiPS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O93505-1 [UniParc]FASTAAdd to Basket

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    MGALRWLFWV GLSYLSCCRL PRAEAQFPRV CMTVEAIRSK RCCPALGPDP    50
    GNVCGVLQGR GWCQGVQVDT QPWSGPYTLR NVDDRERWPL KFFNQSCWCT 100
    GNFAGYNCGD CKFGWTGPDC SVRKPPVVRK NIHSLTVEER EQFLDVLDRA 150
    KTTIHPDYVI ATQHWMSLLG PSGEEPQIAN CSIYNYFVWL HYYSVRDTLL 200
    GPGRPFTAID FSHQGPAFVT WHRYHLLLLE RDLQRLMGNE SFALPYWDFA 250
    TGRNTCDVCT DQLFGAPRPD DPGLISLNSR FSRWQIVCNS LDDYNRLVTL 300
    CNGSDEGLLQ RRPRDSGEQL PTAEDVRRCL SRHEFDSPPF FRNSSFSFRN 350
    ALEGFNKPEG ALNSPMLNLH NLAHSFLNGT RVLPHAAAND PIFVVLHSFT 400
    DAIFDEWMKR FHPPDNAWPE ELAPIGHNRL YNMVPFFPPV TNDQLFQTAE 450
    QLGYTYAIDL PGSLEESQAW AAMVGSTIGG ALIALAVLVL LLVLFQHRKQ 500
    RKGFEPLMNV RFSSKKYMEE A 521
    Length:521
    Mass (Da):59,314
    Last modified:November 1, 1998 - v1
    Checksum:iF0050C577F132EF7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023471 mRNA. Translation: AAC63434.1.
    RefSeqiNP_990266.1. NM_204935.1.
    UniGeneiGga.459.

    Genome annotation databases

    GeneIDi395775.
    KEGGigga:395775.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF023471 mRNA. Translation: AAC63434.1 .
    RefSeqi NP_990266.1. NM_204935.1.
    UniGenei Gga.459.

    3D structure databases

    ProteinModelPortali O93505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000027266.

    Proteomic databases

    PaxDbi O93505.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395775.
    KEGGi gga:395775.

    Organism-specific databases

    CTDi 1638.

    Phylogenomic databases

    eggNOGi NOG301916.
    HOGENOMi HOG000118376.
    HOVERGENi HBG003553.
    KOi K01827.
    PhylomeDBi O93505.

    Enzyme and pathway databases

    UniPathwayi UPA00785 .

    Miscellaneous databases

    NextBioi 20815843.
    PROi O93505.

    Family and domain databases

    Gene3Di 1.10.1280.10. 1 hit.
    InterProi IPR002227. Tyrosinase_Cu-bd.
    IPR008922. Unchr_di-copper_centre.
    [Graphical view ]
    Pfami PF00264. Tyrosinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00092. TYROSINASE.
    SUPFAMi SSF48056. SSF48056. 1 hit.
    PROSITEi PS00497. TYROSINASE_1. 1 hit.
    PS00498. TYROSINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and sequence analysis of a chicken cDNA encoding tyrosinase-related protein-2/DOPAchrome tautomerase."
      April C.S., Jackson I.J., Kidson S.H.
      Gene 219:45-53(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Black Australorp X New Hampshire red.
      Tissue: Neural crest.

    Entry informationi

    Entry nameiTYRP2_CHICK
    AccessioniPrimary (citable) accession number: O93505
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3