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Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.By similarity

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi: melanin biosynthesis

This protein is involved in the pathway melanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway melanin biosynthesis and in Pigment biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi191Zinc ABy similarity1
Metal bindingi213Zinc ABy similarity1
Metal bindingi222Zinc ABy similarity1
Metal bindingi370Zinc BBy similarity1
Metal bindingi374Zinc BBy similarity1
Metal bindingi397Zinc BBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Melanosome membrane By similarity; Single-pass type I membrane protein By similarity
  • Melanosome By similarity

  • Note: Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 474Lumenal, melanosomeSequence analysisAdd BLAST449
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Topological domaini496 – 521CytoplasmicSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000003589426 – 521L-dopachrome tautomeraseAdd BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi302N-linked (GlcNAc...)Sequence analysis1
Glycosylationi343N-linked (GlcNAc...)Sequence analysis1
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO93505.

Expressioni

Tissue specificityi

Melanocytes and retinal pigmented epithelium.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027266.

Structurei

3D structure databases

ProteinModelPortaliO93505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO93505.
KOiK01827.
PhylomeDBiO93505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALRWLFWV GLSYLSCCRL PRAEAQFPRV CMTVEAIRSK RCCPALGPDP
60 70 80 90 100
GNVCGVLQGR GWCQGVQVDT QPWSGPYTLR NVDDRERWPL KFFNQSCWCT
110 120 130 140 150
GNFAGYNCGD CKFGWTGPDC SVRKPPVVRK NIHSLTVEER EQFLDVLDRA
160 170 180 190 200
KTTIHPDYVI ATQHWMSLLG PSGEEPQIAN CSIYNYFVWL HYYSVRDTLL
210 220 230 240 250
GPGRPFTAID FSHQGPAFVT WHRYHLLLLE RDLQRLMGNE SFALPYWDFA
260 270 280 290 300
TGRNTCDVCT DQLFGAPRPD DPGLISLNSR FSRWQIVCNS LDDYNRLVTL
310 320 330 340 350
CNGSDEGLLQ RRPRDSGEQL PTAEDVRRCL SRHEFDSPPF FRNSSFSFRN
360 370 380 390 400
ALEGFNKPEG ALNSPMLNLH NLAHSFLNGT RVLPHAAAND PIFVVLHSFT
410 420 430 440 450
DAIFDEWMKR FHPPDNAWPE ELAPIGHNRL YNMVPFFPPV TNDQLFQTAE
460 470 480 490 500
QLGYTYAIDL PGSLEESQAW AAMVGSTIGG ALIALAVLVL LLVLFQHRKQ
510 520
RKGFEPLMNV RFSSKKYMEE A
Length:521
Mass (Da):59,314
Last modified:November 1, 1998 - v1
Checksum:iF0050C577F132EF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023471 mRNA. Translation: AAC63434.1.
RefSeqiNP_990266.1. NM_204935.1.
UniGeneiGga.459.

Genome annotation databases

GeneIDi395775.
KEGGigga:395775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023471 mRNA. Translation: AAC63434.1.
RefSeqiNP_990266.1. NM_204935.1.
UniGeneiGga.459.

3D structure databases

ProteinModelPortaliO93505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027266.

Proteomic databases

PaxDbiO93505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395775.
KEGGigga:395775.

Organism-specific databases

CTDi1638.

Phylogenomic databases

eggNOGiENOG410IEEB. Eukaryota.
ENOG410XSJD. LUCA.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO93505.
KOiK01827.
PhylomeDBiO93505.

Enzyme and pathway databases

UniPathwayiUPA00785.

Miscellaneous databases

PROiO93505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTYRP2_CHICK
AccessioniPrimary (citable) accession number: O93505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.