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O93505

- TYRP2_CHICK

UniProt

O93505 - TYRP2_CHICK

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Protein
L-dopachrome tautomerase
Gene
DCT, TYRP2
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in regulating eumelanin and phaeomelanin levels.

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911Zinc A By similarity
Metal bindingi213 – 2131Zinc A By similarity
Metal bindingi222 – 2221Zinc A By similarity
Metal bindingi370 – 3701Zinc B By similarity
Metal bindingi374 – 3741Zinc B By similarity
Metal bindingi397 – 3971Zinc B By similarity

GO - Molecular functioni

  1. dopachrome isomerase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 474449Lumenal, melanosome Reviewed prediction
Add
BLAST
Transmembranei475 – 49521Helical; Reviewed prediction
Add
BLAST
Topological domaini496 – 52126Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 521496L-dopachrome tautomerase
PRO_0000035894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi302 – 3021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi378 – 3781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO93505.

Expressioni

Tissue specificityi

Melanocytes and retinal pigmented epithelium.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex By similarity.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027266.

Structurei

3D structure databases

ProteinModelPortaliO93505.

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301916.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
KOiK01827.
PhylomeDBiO93505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93505-1 [UniParc]FASTAAdd to Basket

« Hide

MGALRWLFWV GLSYLSCCRL PRAEAQFPRV CMTVEAIRSK RCCPALGPDP    50
GNVCGVLQGR GWCQGVQVDT QPWSGPYTLR NVDDRERWPL KFFNQSCWCT 100
GNFAGYNCGD CKFGWTGPDC SVRKPPVVRK NIHSLTVEER EQFLDVLDRA 150
KTTIHPDYVI ATQHWMSLLG PSGEEPQIAN CSIYNYFVWL HYYSVRDTLL 200
GPGRPFTAID FSHQGPAFVT WHRYHLLLLE RDLQRLMGNE SFALPYWDFA 250
TGRNTCDVCT DQLFGAPRPD DPGLISLNSR FSRWQIVCNS LDDYNRLVTL 300
CNGSDEGLLQ RRPRDSGEQL PTAEDVRRCL SRHEFDSPPF FRNSSFSFRN 350
ALEGFNKPEG ALNSPMLNLH NLAHSFLNGT RVLPHAAAND PIFVVLHSFT 400
DAIFDEWMKR FHPPDNAWPE ELAPIGHNRL YNMVPFFPPV TNDQLFQTAE 450
QLGYTYAIDL PGSLEESQAW AAMVGSTIGG ALIALAVLVL LLVLFQHRKQ 500
RKGFEPLMNV RFSSKKYMEE A 521
Length:521
Mass (Da):59,314
Last modified:November 1, 1998 - v1
Checksum:iF0050C577F132EF7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023471 mRNA. Translation: AAC63434.1.
RefSeqiNP_990266.1. NM_204935.1.
UniGeneiGga.459.

Genome annotation databases

GeneIDi395775.
KEGGigga:395775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF023471 mRNA. Translation: AAC63434.1 .
RefSeqi NP_990266.1. NM_204935.1.
UniGenei Gga.459.

3D structure databases

ProteinModelPortali O93505.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000027266.

Proteomic databases

PaxDbi O93505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 395775.
KEGGi gga:395775.

Organism-specific databases

CTDi 1638.

Phylogenomic databases

eggNOGi NOG301916.
HOGENOMi HOG000118376.
HOVERGENi HBG003553.
KOi K01827.
PhylomeDBi O93505.

Enzyme and pathway databases

UniPathwayi UPA00785 .

Miscellaneous databases

NextBioi 20815843.
PROi O93505.

Family and domain databases

Gene3Di 1.10.1280.10. 1 hit.
InterProi IPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view ]
Pfami PF00264. Tyrosinase. 1 hit.
[Graphical view ]
PRINTSi PR00092. TYROSINASE.
SUPFAMi SSF48056. SSF48056. 1 hit.
PROSITEi PS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of a chicken cDNA encoding tyrosinase-related protein-2/DOPAchrome tautomerase."
    April C.S., Jackson I.J., Kidson S.H.
    Gene 219:45-53(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Black Australorp X New Hampshire red.
    Tissue: Neural crest.

Entry informationi

Entry nameiTYRP2_CHICK
AccessioniPrimary (citable) accession number: O93505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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