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Protein

L-dopachrome tautomerase

Gene

DCT

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in regulating eumelanin and phaeomelanin levels.

Catalytic activityi

L-dopachrome = 5,6-dihydroxyindole-2-carboxylate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi191 – 1911Zinc ABy similarity
Metal bindingi213 – 2131Zinc ABy similarity
Metal bindingi222 – 2221Zinc ABy similarity
Metal bindingi370 – 3701Zinc BBy similarity
Metal bindingi374 – 3741Zinc BBy similarity
Metal bindingi397 – 3971Zinc BBy similarity

GO - Molecular functioni

  1. dopachrome isomerase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. melanin biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Melanin biosynthesis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00785.

Names & Taxonomyi

Protein namesi
Recommended name:
L-dopachrome tautomerase (EC:5.3.3.12)
Short name:
DCT
Short name:
DT
Alternative name(s):
L-dopachrome Delta-isomerase
Tyrosinase-related protein 2
Short name:
TRP-2
Short name:
TRP2
Gene namesi
Name:DCT
Synonyms:TYRP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 474449Lumenal, melanosomeSequence AnalysisAdd
BLAST
Transmembranei475 – 49521HelicalSequence AnalysisAdd
BLAST
Topological domaini496 – 52126CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 521496L-dopachrome tautomerasePRO_0000035894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi302 – 3021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO93505.

Expressioni

Tissue specificityi

Melanocytes and retinal pigmented epithelium.

Interactioni

Subunit structurei

Tyrosinase, TYRP1 and DCT/TYRP2 may form a multienzyme complex.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027266.

Structurei

3D structure databases

ProteinModelPortaliO93505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tyrosinase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG301916.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO93505.
KOiK01827.
PhylomeDBiO93505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALRWLFWV GLSYLSCCRL PRAEAQFPRV CMTVEAIRSK RCCPALGPDP
60 70 80 90 100
GNVCGVLQGR GWCQGVQVDT QPWSGPYTLR NVDDRERWPL KFFNQSCWCT
110 120 130 140 150
GNFAGYNCGD CKFGWTGPDC SVRKPPVVRK NIHSLTVEER EQFLDVLDRA
160 170 180 190 200
KTTIHPDYVI ATQHWMSLLG PSGEEPQIAN CSIYNYFVWL HYYSVRDTLL
210 220 230 240 250
GPGRPFTAID FSHQGPAFVT WHRYHLLLLE RDLQRLMGNE SFALPYWDFA
260 270 280 290 300
TGRNTCDVCT DQLFGAPRPD DPGLISLNSR FSRWQIVCNS LDDYNRLVTL
310 320 330 340 350
CNGSDEGLLQ RRPRDSGEQL PTAEDVRRCL SRHEFDSPPF FRNSSFSFRN
360 370 380 390 400
ALEGFNKPEG ALNSPMLNLH NLAHSFLNGT RVLPHAAAND PIFVVLHSFT
410 420 430 440 450
DAIFDEWMKR FHPPDNAWPE ELAPIGHNRL YNMVPFFPPV TNDQLFQTAE
460 470 480 490 500
QLGYTYAIDL PGSLEESQAW AAMVGSTIGG ALIALAVLVL LLVLFQHRKQ
510 520
RKGFEPLMNV RFSSKKYMEE A
Length:521
Mass (Da):59,314
Last modified:November 1, 1998 - v1
Checksum:iF0050C577F132EF7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023471 mRNA. Translation: AAC63434.1.
RefSeqiNP_990266.1. NM_204935.1.
UniGeneiGga.459.

Genome annotation databases

GeneIDi395775.
KEGGigga:395775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF023471 mRNA. Translation: AAC63434.1.
RefSeqiNP_990266.1. NM_204935.1.
UniGeneiGga.459.

3D structure databases

ProteinModelPortaliO93505.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027266.

Proteomic databases

PaxDbiO93505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395775.
KEGGigga:395775.

Organism-specific databases

CTDi1638.

Phylogenomic databases

eggNOGiNOG301916.
HOGENOMiHOG000118376.
HOVERGENiHBG003553.
InParanoidiO93505.
KOiK01827.
PhylomeDBiO93505.

Enzyme and pathway databases

UniPathwayiUPA00785.

Miscellaneous databases

NextBioi20815843.
PROiO93505.

Family and domain databases

Gene3Di1.10.1280.10. 1 hit.
InterProiIPR002227. Tyrosinase_Cu-bd.
IPR008922. Unchr_di-copper_centre.
[Graphical view]
PfamiPF00264. Tyrosinase. 1 hit.
[Graphical view]
PRINTSiPR00092. TYROSINASE.
SUPFAMiSSF48056. SSF48056. 1 hit.
PROSITEiPS00497. TYROSINASE_1. 1 hit.
PS00498. TYROSINASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence analysis of a chicken cDNA encoding tyrosinase-related protein-2/DOPAchrome tautomerase."
    April C.S., Jackson I.J., Kidson S.H.
    Gene 219:45-53(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Black Australorp X New Hampshire red.
    Tissue: Neural crest.

Entry informationi

Entry nameiTYRP2_CHICK
AccessioniPrimary (citable) accession number: O93505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1998
Last modified: February 4, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.