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Protein
Submitted name:

GTP-binding protein

Gene

cRhoA

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • cardiac epithelial to mesenchymal transition Source: AgBase
  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • regulation of cytoskeleton organization Source: AgBase
  • regulation of myotome development Source: AgBase
  • skeletal muscle satellite cell migration Source: AgBase
  • small GTPase mediated signal transduction Source: InterPro
  • wound healing, spreading of cells Source: AgBase

Keywordsi

LigandGTP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-114604 GPVI-mediated activation cascade
R-GGA-193634 Axonal growth inhibition (RHOA activation)
R-GGA-194840 Rho GTPase cycle
R-GGA-198203 PI3K/AKT activation
R-GGA-209563 Axonal growth stimulation
R-GGA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-GGA-392451 G beta:gamma signalling through PI3Kgamma
R-GGA-3928662 EPHB-mediated forward signaling
R-GGA-3928663 EPHA-mediated growth cone collapse
R-GGA-416482 G alpha (12/13) signalling events
R-GGA-416550 Sema4D mediated inhibition of cell attachment and migration
R-GGA-416572 Sema4D induced cell migration and growth-cone collapse
R-GGA-4420097 VEGFA-VEGFR2 Pathway
R-GGA-5625740 RHO GTPases activate PKNs
R-GGA-5625900 RHO GTPases activate CIT
R-GGA-5625970 RHO GTPases activate KTN1
R-GGA-5627117 RHO GTPases Activate ROCKs
R-GGA-5666185 RHO GTPases Activate Rhotekin and Rhophilins
R-GGA-5689896 Ovarian tumor domain proteases
R-GGA-6798695 Neutrophil degranulation
R-GGA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-GGA-8985586 SLIT2:ROBO1 increases RHOA activity

Names & Taxonomyi

Protein namesi
Submitted name:
GTP-binding proteinImported
Submitted name:
GTPase cRhoAImported
Submitted name:
Ras homolog family member AImported
Submitted name:
RhoA GTPaseImported
Gene namesi
Name:cRhoAImported
Synonyms:RHOAImported, rhoAImported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 12

Subcellular locationi

PTM / Processingi

Proteomic databases

PRIDEiO93467

Expressioni

Gene expression databases

BgeeiENSGALG00000003806

Interactioni

Protein-protein interaction databases

IntActiO93467, 1 interactor
STRINGi9031.ENSGALP00000033584

Family & Domainsi

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
KOiK04513
OMAiQKIGARH
OrthoDBiEOG091G0QVS
TreeFamiTF300837

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

O93467-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG
60 70 80 90 100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT
110 120 130 140 150
PEVKHFCPNV PIILVGNKKD LRNDEHTRRE LAKMKQEPVK PEEGRDMANR
160 170 180 190
IGAFGYMECS AKTKDGVREV FEMATRAALQ ARRGKKKSGC LLL
Length:193
Mass (Da):21,782
Last modified:November 1, 1998 - v1
Checksum:iC4CFCDC31FF858BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000419 Genomic DNA No translation available.
U79757 mRNA Translation: AAC18962.1
AF098513 mRNA Translation: AAD12255.1
AJ294705 mRNA Translation: CAC08447.1
RefSeqiNP_990035.1, NM_204704.1
UniGeneiGga.39064

Genome annotation databases

EnsembliENSGALT00000034226; ENSGALP00000033584; ENSGALG00000003806
ENSGALT00000069049; ENSGALP00000051789; ENSGALG00000003806
ENSGALT00000082855; ENSGALP00000048923; ENSGALG00000003806
ENSGALT00000087221; ENSGALP00000062680; ENSGALG00000003806
ENSGALT00000089943; ENSGALP00000059380; ENSGALG00000003806
GeneIDi395442
KEGGigga:395442

Similar proteinsi

Entry informationi

Entry nameiO93467_CHICK
AccessioniPrimary (citable) accession number: O93467
Secondary accession number(s): F1NLM4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health