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Protein

Tyrosine-protein kinase receptor

Gene
N/A
Organism
Scophthalmus maximus (Turbot) (Psetta maxima)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1139Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
OrganismiScophthalmus maximus (Turbot) (Psetta maxima)Imported
Taxonomic identifieri52904 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataCarangariaPleuronectiformesPleuronectoideiScophthalmidaeScophthalmus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei937 – 962HelicalSequence analysisAdd BLAST26

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_500416053030 – 1418Tyrosine-protein kinase receptorSequence analysisAdd BLAST1389

Keywords - PTMi

PhosphoproteinUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliO93457.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini315 – 3464Fe-4S ferredoxin-typeInterPro annotationAdd BLAST32
Domaini488 – 605Fibronectin type-IIIInterPro annotationAdd BLAST118
Domaini609 – 708Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini732 – 834Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini840 – 933Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1003 – 1278Protein kinaseInterPro annotationAdd BLAST276

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 2 hits.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR003961. FN3_dom.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
PS50853. FN3. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRAEWNRL TLFWGLMLGL SSCHRPAAAK ICGPSIDIGN DITEFRRLEN
60 70 80 90 100
CTVVEGYLQI LLIGDKNNSN INQEFFRSLS FPKLTMITDY LLLFRVSGLD
110 120 130 140 150
SLSTLFPNLT VIRGRSLFYN YALVIFEMTS LKDIGLYNLR NITRGAIRIE
160 170 180 190 200
KNPELCYLDS IDWSLIMDAE FNNYIAGNKQ SKECSDVCPG IMENNPQCRK
210 220 230 240 250
TMFNSNYNYR CWNSNKCQKE CPERCARQAC TADGECCHPQ CLGSCTAPGS
260 270 280 290 300
DTACAACVHY YHQGRCVAEC PPGTYKFEDW RCISAELCSK VHLPEYDSFI
310 320 330 340 350
IHGEECMPEC PSGYTRTTPD SMTCTACDGL CDKVCEEKVI DSMDAAQSLK
360 370 380 390 400
GCTVIKGNLH INIRRGHNMV AELESFTGLI KRVTGYVRIR HSHTLSSLAF
410 420 430 440 450
LRGLRYIDGE VLLDDMYAFA AFDNQQLQYL WDWKQHNLTI KAGKLFFRAN
460 470 480 490 500
PKLCTSEIRN MWDKTGIRGR FDESVFRNNG DRASCESTIL KFKSSSTSST
510 520 530 540 550
RIKLTWQRYR PPDYRDLISF IVYYKEAPYQ NITEYDGQDG CGSNSWIMVD
560 570 580 590 600
VELRPDKDLD PGVLLSSLKP WTQYAVFVKA ITLMVEDKHM PSAKSKVVYI
610 620 630 640 650
RTSPSAPSMP QDVRAYSNSS TQLVVRWSPP VSPNGNQTYY LVRWQQQAED
660 670 680 690 700
RELYQHNYCS KELKIPIRIA AIGVGDQEED TKPTKPDPEG ADKGPCCPCP
710 720 730 740 750
KSVEDLEAEA ADASYRKVFE NFLHNSIFTP RPPDRRRRDL FGFANSTHSR
760 770 780 790 800
RHRLHTNSSH VPPHQAAGNN SSSTTAEPEQ ADREFEFMEQ AVSERVQIFD
810 820 830 840 850
LQPFTVYRID IHACNRQVQR CSAAEFVFSR TKPAEKADDI PGQVTWEGHE
860 870 880 890 900
DWVFLRWPEP PHPNRLVLMY EIKFKLAAET EKHECVSGQT YQNQRGVRLS
910 920 930 940 950
NLSPGHYSVR VRATSLAGNG SWTNAVDLYV AERYENVLYA MIFIPIAIIL
960 970 980 990 1000
FICLLVTMLV VLNKKRNSDR LGNGVLYASV NPEYFSAAEM YVPDEWEVAR
1010 1020 1030 1040 1050
EKIALSRELG QGSFGMVYEG LAKGVVKDEP ETRVAIKTVN ESASMRERIE
1060 1070 1080 1090 1100
FLNEASVMKE FNCHHVVRLL GVVSQGQPTL VIMELMTRGD LKSYLRSLRP
1110 1120 1130 1140 1150
KEQQWSSLSL PPLRKMLQMA GQIADGMAYL NANKFVHRDL AARNCMVADD
1160 1170 1180 1190 1200
FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMSPESLKD GVFTTHSDVW
1210 1220 1230 1240 1250
SFGVVLWEIS TLAEQPYQGL SNEQVVRFVM EGGLLEKPQN CPDMLFELMR
1260 1270 1280 1290 1300
MCWQFNPKMR PAFVEIISSL KDELEPSFKD SSFFYSADNK PVDDPQVHQD
1310 1320 1330 1340 1350
KMDSVDDVPL DPPSSTQPQQ SPVPQQTPPP PSSEAPPAPS LSPSSPSSPC
1360 1370 1380 1390 1400
TSTAAMDKQA SGASGNGLSG PSHAAGSGLG TSAGVAMCPS LEELPPYAHM
1410
NGGRKNERAM PLLQSSAC
Length:1,418
Mass (Da):159,828
Last modified:November 1, 1998 - v1
Checksum:i5D9921332113C4AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224993 mRNA. Translation: CAA12278.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224993 mRNA. Translation: CAA12278.1.

3D structure databases

ProteinModelPortaliO93457.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 4 hits.
3.80.20.20. 2 hits.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR003961. FN3_dom.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR000494. Rcpt_L-dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFiPIRSF000620. Insulin_receptor. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
SSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS51379. 4FE4S_FER_2. 1 hit.
PS50853. FN3. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO93457_SCOMX
AccessioniPrimary (citable) accession number: O93457
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.