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Protein

Dermorphin peptides

Gene
N/A
Organism
Pachymedusa dacnicolor (Giant mexican leaf frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Dermorphin has a very potent opiate-like activity. It has high affinity and selectivity for mu-type opioid receptors (By similarity).By similarity
Deltorphin has a very potent opiate-like activity. It has high affinity and selectivity for delta-type opioid receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Endorphin, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Dermorphin peptides
Cleaved into the following 2 chains:
OrganismiPachymedusa dacnicolor (Giant mexican leaf frog)Imported
Taxonomic identifieri75988 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePachymedusa

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000001022223 – 46CuratedAdd BLAST24
PeptideiPRO_000001022349 – 55Dermorphin7
PropeptideiPRO_000001022457 – 82Add BLAST26
PeptideiPRO_000001022585 – 91Dermorphin7
PropeptideiPRO_000001022693 – 118Add BLAST26
PeptideiPRO_0000010227121 – 127Dermorphin7
PropeptideiPRO_0000010228129 – 154Add BLAST26
PeptideiPRO_0000010229157 – 163Dermorphin7
PropeptideiPRO_0000010230165 – 186Add BLAST22
PeptideiPRO_0000010231189 – 195[Ile2]-deltorphin7
PropeptideiPRO_0000010232196 – 2016

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei50D-alanine (Ala)By similarity1
Modified residuei55Serine amideBy similarity1
Modified residuei86D-alanine (Ala)By similarity1
Modified residuei91Serine amideBy similarity1
Modified residuei122D-alanine (Ala)By similarity1
Modified residuei127Serine amideBy similarity1
Modified residuei158D-alanine (Ala)By similarity1
Modified residuei163Serine amideBy similarity1
Modified residuei190D-allo-isoleucineCurated1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, D-amino acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG005448.

Family and domain databases

InterProiIPR004275. Frog_antimicrobial_propeptide.
[Graphical view]
PfamiPF03032. FSAP_sig_propep. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93456-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLKKSLLL ILFLGLVSLS ICEEQKREIE EDENENEEER NEASEMKRYA
60 70 80 90 100
FGYPSGEEKK IKRETEEDEN ENEEERNEAS EMKRYAFGYP SGEEKKIKRE
110 120 130 140 150
TEEDENENEE ERNEASEMKR YAFGYPSGEE KKIKRETEED ENENEEERNE
160 170 180 190 200
GSEMKRYAFG YPSGGAKRMK RKPVEEEENH VAGSKMKRYI FHLMDGEVKK

I
Length:201
Mass (Da):23,887
Last modified:November 1, 1998 - v1
Checksum:i2F324D6701CDDA31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005443 mRNA. Translation: CAA06546.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ005443 mRNA. Translation: CAA06546.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005448.

Family and domain databases

InterProiIPR004275. Frog_antimicrobial_propeptide.
[Graphical view]
PfamiPF03032. FSAP_sig_propep. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEM_PACDA
AccessioniPrimary (citable) accession number: O93456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: November 1, 1998
Last modified: January 20, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.