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O93456

- DEM_PACDA

UniProt

O93456 - DEM_PACDA

Protein

Dermorphin peptides

Gene
N/A
Organism
Pachymedusa dacnicolor (Giant mexican leaf frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    Functioni

    Dermorphin has a very potent opiate-like activity. It has high affinity and selectivity for mu-type opioid receptors By similarity.By similarity
    Deltorphin has a very potent opiate-like activity. It has high affinity and selectivity for delta-type opioid receptors By similarity.By similarity

    GO - Molecular functioni

    1. opioid peptide activity Source: UniProtKB

    GO - Biological processi

    1. defense response Source: UniProtKB
    2. defense response to bacterium Source: InterPro
    3. neuropeptide signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Amphibian defense peptide, Endorphin, Opioid peptide

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dermorphin peptides
    Cleaved into the following 2 chains:
    OrganismiPachymedusa dacnicolor (Giant mexican leaf frog)Imported
    Taxonomic identifieri75988 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePachymedusa

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Propeptidei23 – 4624CuratedPRO_0000010222Add
    BLAST
    Peptidei49 – 557DermorphinPRO_0000010223
    Propeptidei57 – 8226PRO_0000010224Add
    BLAST
    Peptidei85 – 917DermorphinPRO_0000010225
    Propeptidei93 – 11826PRO_0000010226Add
    BLAST
    Peptidei121 – 1277DermorphinPRO_0000010227
    Propeptidei129 – 15426PRO_0000010228Add
    BLAST
    Peptidei157 – 1637DermorphinPRO_0000010229
    Propeptidei165 – 18622PRO_0000010230Add
    BLAST
    Peptidei189 – 1957[Ile2]-deltorphinPRO_0000010231
    Propeptidei196 – 2016PRO_0000010232

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei50 – 501D-alanine (Ala)By similarity
    Modified residuei55 – 551Serine amideBy similarity
    Modified residuei86 – 861D-alanine (Ala)By similarity
    Modified residuei91 – 911Serine amideBy similarity
    Modified residuei122 – 1221D-alanine (Ala)By similarity
    Modified residuei127 – 1271Serine amideBy similarity
    Modified residuei158 – 1581D-alanine (Ala)By similarity
    Modified residuei163 – 1631Serine amideBy similarity
    Modified residuei190 – 1901D-allo-isoleucineCurated

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, D-amino acid

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG005448.

    Family and domain databases

    InterProiIPR004275. Brevinin.
    [Graphical view]
    PfamiPF03032. Brevenin. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O93456-1 [UniParc]FASTAAdd to Basket

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    MSFLKKSLLL ILFLGLVSLS ICEEQKREIE EDENENEEER NEASEMKRYA    50
    FGYPSGEEKK IKRETEEDEN ENEEERNEAS EMKRYAFGYP SGEEKKIKRE 100
    TEEDENENEE ERNEASEMKR YAFGYPSGEE KKIKRETEED ENENEEERNE 150
    GSEMKRYAFG YPSGGAKRMK RKPVEEEENH VAGSKMKRYI FHLMDGEVKK 200
    I 201
    Length:201
    Mass (Da):23,887
    Last modified:November 1, 1998 - v1
    Checksum:i2F324D6701CDDA31
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005443 mRNA. Translation: CAA06546.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ005443 mRNA. Translation: CAA06546.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005448.

    Family and domain databases

    InterProi IPR004275. Brevinin.
    [Graphical view ]
    Pfami PF03032. Brevenin. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa dacnicolor and Agalychnis annae."
      Wechselberger C., Severini C., Kreil G., Negri L.
      FEBS Lett. 429:41-43(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 189-195.
      Tissue: SkinCurated.

    Entry informationi

    Entry nameiDEM_PACDA
    AccessioniPrimary (citable) accession number: O93456
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3