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O93456 (DEM_PACDA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dermorphin peptides

Cleaved into the following 2 chains:

  1. [Ile2]-deltorphin
  2. Dermorphin
OrganismPachymedusa dacnicolor (Giant mexican leaf frog)
Taxonomic identifier75988 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePachymedusa

Protein attributes

Sequence length201 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dermorphin has a very potent opiate-like activity. It has high affinity and selectivity for mu-type opioid receptors By similarity. UniProtKB P05422

Deltorphin has a very potent opiate-like activity. It has high affinity and selectivity for delta-type opioid receptors By similarity. UniProtKB P05422

Subcellular location

Secreted.

Tissue specificity

Expressed by the skin glands.

Sequence similarities

Belongs to the frog skin active peptide (FSAP) family. Dermorphin subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 4624
PRO_0000010222
Peptide49 – 557Dermorphin Ref.1
PRO_0000010223
Propeptide57 – 8226
PRO_0000010224
Peptide85 – 917Dermorphin Ref.1
PRO_0000010225
Propeptide93 – 11826
PRO_0000010226
Peptide121 – 1277Dermorphin Ref.1
PRO_0000010227
Propeptide129 – 15426
PRO_0000010228
Peptide157 – 1637Dermorphin Ref.1
PRO_0000010229
Propeptide165 – 18622
PRO_0000010230
Peptide189 – 1957[Ile2]-deltorphin Ref.1
PRO_0000010231
Propeptide196 – 2016
PRO_0000010232

Amino acid modifications

Modified residue501D-alanine (Ala) By similarity UniProtKB P05422
Modified residue551Serine amide By similarity UniProtKB P05422
Modified residue861D-alanine (Ala) By similarity UniProtKB P05422
Modified residue911Serine amide By similarity UniProtKB P05422
Modified residue1221D-alanine (Ala) By similarity UniProtKB P05422
Modified residue1271Serine amide By similarity UniProtKB P05422
Modified residue1581D-alanine (Ala) By similarity UniProtKB P05422
Modified residue1631Serine amide By similarity UniProtKB P05422
Modified residue1901D-allo-isoleucine Probable UniProtKB P05422

Sequences

Sequence LengthMass (Da)Tools
O93456 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 2F324D6701CDDA31

FASTA20123,887
        10         20         30         40         50         60 
MSFLKKSLLL ILFLGLVSLS ICEEQKREIE EDENENEEER NEASEMKRYA FGYPSGEEKK 

        70         80         90        100        110        120 
IKRETEEDEN ENEEERNEAS EMKRYAFGYP SGEEKKIKRE TEEDENENEE ERNEASEMKR 

       130        140        150        160        170        180 
YAFGYPSGEE KKIKRETEED ENENEEERNE GSEMKRYAFG YPSGGAKRMK RKPVEEEENH 

       190        200 
VAGSKMKRYI FHLMDGEVKK I 

« Hide

References

[1]"A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa dacnicolor and Agalychnis annae."
Wechselberger C., Severini C., Kreil G., Negri L.
FEBS Lett. 429:41-43(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 189-195.
Tissue: Skin.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ005443 mRNA. Translation: CAA06546.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG005448.

Family and domain databases

InterProIPR004275. Brevinin.
[Graphical view]
PfamPF03032. Brevenin. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDEM_PACDA
AccessionPrimary (citable) accession number: O93456
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families