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O93456

- DEM_PACDA

UniProt

O93456 - DEM_PACDA

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Protein

Dermorphin peptides

Gene
N/A
Organism
Pachymedusa dacnicolor (Giant mexican leaf frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Dermorphin has a very potent opiate-like activity. It has high affinity and selectivity for mu-type opioid receptors By similarity.By similarity
Deltorphin has a very potent opiate-like activity. It has high affinity and selectivity for delta-type opioid receptors By similarity.By similarity

GO - Molecular functioni

  1. opioid peptide activity Source: UniProtKB

GO - Biological processi

  1. defense response Source: UniProtKB
  2. defense response to bacterium Source: InterPro
  3. neuropeptide signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, Endorphin, Opioid peptide

Names & Taxonomyi

Protein namesi
Recommended name:
Dermorphin peptides
Cleaved into the following 2 chains:
OrganismiPachymedusa dacnicolor (Giant mexican leaf frog)
Taxonomic identifieri75988 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaHylidaePhyllomedusinaePachymedusa

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Propeptidei23 – 4624PRO_0000010222Add
BLAST
Peptidei49 – 557Dermorphin1 PublicationPRO_0000010223
Propeptidei57 – 8226PRO_0000010224Add
BLAST
Peptidei85 – 917Dermorphin1 PublicationPRO_0000010225
Propeptidei93 – 11826PRO_0000010226Add
BLAST
Peptidei121 – 1277Dermorphin1 PublicationPRO_0000010227
Propeptidei129 – 15426PRO_0000010228Add
BLAST
Peptidei157 – 1637Dermorphin1 PublicationPRO_0000010229
Propeptidei165 – 18622PRO_0000010230Add
BLAST
Peptidei189 – 1957[Ile2]-deltorphin1 PublicationPRO_0000010231
Propeptidei196 – 2016PRO_0000010232

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei50 – 501D-alanine (Ala) By similarityBy similarity
Modified residuei55 – 551Serine amide By similarityBy similarity
Modified residuei86 – 861D-alanine (Ala) By similarityBy similarity
Modified residuei91 – 911Serine amide By similarityBy similarity
Modified residuei122 – 1221D-alanine (Ala) By similarityBy similarity
Modified residuei127 – 1271Serine amide By similarityBy similarity
Modified residuei158 – 1581D-alanine (Ala) By similarityBy similarity
Modified residuei163 – 1631Serine amide By similarityBy similarity
Modified residuei190 – 1901D-allo-isoleucine InferredBy similarity

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, D-amino acid

Expressioni

Tissue specificityi

Expressed by the skin glands.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG005448.

Family and domain databases

InterProiIPR004275. Brevinin.
[Graphical view]
PfamiPF03032. Brevenin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93456-1 [UniParc]FASTAAdd to Basket

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MSFLKKSLLL ILFLGLVSLS ICEEQKREIE EDENENEEER NEASEMKRYA    50
FGYPSGEEKK IKRETEEDEN ENEEERNEAS EMKRYAFGYP SGEEKKIKRE 100
TEEDENENEE ERNEASEMKR YAFGYPSGEE KKIKRETEED ENENEEERNE 150
GSEMKRYAFG YPSGGAKRMK RKPVEEEENH VAGSKMKRYI FHLMDGEVKK 200
I 201
Length:201
Mass (Da):23,887
Last modified:November 1, 1998 - v1
Checksum:i2F324D6701CDDA31
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005443 mRNA. Translation: CAA06546.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ005443 mRNA. Translation: CAA06546.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005448.

Family and domain databases

InterProi IPR004275. Brevinin.
[Graphical view ]
Pfami PF03032. Brevenin. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa dacnicolor and Agalychnis annae."
    Wechselberger C., Severini C., Kreil G., Negri L.
    FEBS Lett. 429:41-43(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 189-195.
    Tissue: Skin.

Entry informationi

Entry nameiDEM_PACDA
AccessioniPrimary (citable) accession number: O93456
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: November 1, 1998
Last modified: April 3, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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