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Protein

Signal transducing adapter molecule 2

Gene

STAM2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducing adapter molecule 2
Short name:
STAM-2
Alternative name(s):
Epidermal growth factor receptor-associated protein with SH3 and TAM domain
Gene namesi
Name:STAM2
Synonyms:EAST
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468Signal transducing adapter molecule 2PRO_0000190150Add
BLAST

Post-translational modificationi

Phosphorylated in response to EGF and PDGF. Phosphorylated by SRC.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO93436.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Interactioni

Subunit structurei

Component of the ESCRT-0 complex composed of STAM2 and HGS.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020413.

Structurei

3D structure databases

ProteinModelPortaliO93436.
SMRiO93436. Positions 1-150, 195-268.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 143128VHSPROSITE-ProRule annotationAdd
BLAST
Domaini164 – 18320UIMPROSITE-ProRule annotationAdd
BLAST
Domaini201 – 26060SH3PROSITE-ProRule annotationAdd
BLAST
Domaini358 – 37518ITAMAdd
BLAST

Sequence similaritiesi

Belongs to the STAM family.Curated
Contains 1 ITAM domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 UIM (ubiquitin-interacting motif) domain.PROSITE-ProRule annotation
Contains 1 VHS domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2199. Eukaryota.
ENOG410XTSY. LUCA.
HOGENOMiHOG000231952.
HOVERGENiHBG053175.
InParanoidiO93436.
KOiK04705.
PhylomeDBiO93436.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF02809. UIM. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93436-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLSASNPFE QDVEKATNEH NNSEDWGLIM DICDKVGSTP NGAKDCLKAI
60 70 80 90 100
MRRVNHKVPH VALQALTLLG ACVSNCGRIF HLEVCSRDFA TEARGIINKA
110 120 130 140 150
HGKVSEKLKT LMVEWSEEFQ KDPQCSLISA TIKSLKEEGV TFPAAGSQAT
160 170 180 190 200
TNAAKNGSSL SKNKEDEDIR KAIELSLQEQ KQQQMETKSL YPSAEIQQTN
210 220 230 240 250
QNLRKVRALY DFEAVEDNEL TFKSGEIIFV LDDSDTDWWK GENHRGVGLF
260 270 280 290 300
PSNFVTSDLN VEPEAATVDN SCVPEDATEE IKKAEPEAVY IDEDKMDKTL
310 320 330 340 350
QVLQSIDPTD LNLDTDLLDS EVICQQMGPM IDEKLEEIDR KHSELSELNV
360 370 380 390 400
KVLEALELYN KLMNETPMYS AYSKLHHPAQ YPPTSSGVSV QSYPVQPPSG
410 420 430 440 450
NYMIQGVHQV TVSQGYGLGP DQMGQLRSLP QNINSSDCNL YTKSNRQRMC
460
HMKAITTWQR FSKHTSER
Length:468
Mass (Da):52,407
Last modified:November 1, 1998 - v1
Checksum:iFAE790D5BDDC78A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224514 mRNA. Translation: CAA12023.1.
RefSeqiNP_001012940.1. NM_001012922.1.
UniGeneiGga.44542.
Gga.49532.

Genome annotation databases

GeneIDi424317.
KEGGigga:424317.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ224514 mRNA. Translation: CAA12023.1.
RefSeqiNP_001012940.1. NM_001012922.1.
UniGeneiGga.44542.
Gga.49532.

3D structure databases

ProteinModelPortaliO93436.
SMRiO93436. Positions 1-150, 195-268.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020413.

Proteomic databases

PaxDbiO93436.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi424317.
KEGGigga:424317.

Organism-specific databases

CTDi10254.

Phylogenomic databases

eggNOGiKOG2199. Eukaryota.
ENOG410XTSY. LUCA.
HOGENOMiHOG000231952.
HOVERGENiHBG053175.
InParanoidiO93436.
KOiK04705.
PhylomeDBiO93436.

Miscellaneous databases

PROiO93436.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR008942. ENTH_VHS.
IPR001452. SH3_domain.
IPR003903. UIM_dom.
IPR002014. VHS_dom.
[Graphical view]
PfamiPF00018. SH3_1. 1 hit.
PF02809. UIM. 1 hit.
PF00790. VHS. 1 hit.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00326. SH3. 1 hit.
SM00726. UIM. 1 hit.
SM00288. VHS. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50002. SH3. 1 hit.
PS50330. UIM. 1 hit.
PS50179. VHS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTAM2_CHICK
AccessioniPrimary (citable) accession number: O93436
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.