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O93434 (RCN1_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment By similarity.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainRepeat
Signal
   LigandCalcium
Metal-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 322303Reticulocalbin-1
PRO_0000004147

Regions

Domain70 – 10536EF-hand 1
Domain106 – 14136EF-hand 2
Domain157 – 19236EF-hand 3
Domain194 – 22936EF-hand 4
Domain235 – 27036EF-hand 5
Domain271 – 30636EF-hand 6
Calcium binding83 – 94121; possibly ancestral Potential
Calcium binding119 – 130122 Potential
Calcium binding170 – 181123; possibly ancestral Potential
Calcium binding207 – 218124 Potential
Calcium binding248 – 259125 Potential
Calcium binding284 – 295126 Potential
Motif319 – 3224Prevents secretion from ER Potential

Amino acid modifications

Glycosylation441N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
O93434 [UniParc].

Last modified November 1, 1998. Version 1.
Checksum: 85F99C053AC34C5C

FASTA32238,207
        10         20         30         40         50         60 
MDVLGFICAV FLGTVVLHAK PTVRKDRVLY QDPELLRQAT NEDNNSFQYD HEVFLGKEES 

        70         80         90        100        110        120 
KTFDQLSPEE SKDRLSKIVD RIDGDGNSYI TTDELKAWIK RVQKRYVYEN VVKVWADYDL 

       130        140        150        160        170        180 
NKDNKISWEE YKQATYGYYL SNPEEFDETT DQFSFKKMLP RDERRFKRAD LDGDSAANRE 

       190        200        210        220        230        240 
EFTSFLHPEE FEHMKDIVVL ETLEDIDKNS DGHVDEDEYI ADMFAHEDRG PEPEWVKTER 

       250        260        270        280        290        300 
EQFSDFRDLN KDGKMDLDEI RHWIMPQDYD HAQAEARHLV YESDKDKDQM LTKEEILDNW 

       310        320 
NMFVGSQATN YGEDLTRNHD EL 

« Hide

References

[1]"Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13."
Miles C., Elgar G., Coles E., Kleinjan D.J., Van Heyningen V., Hastie N.
Proc. Natl. Acad. Sci. U.S.A. 95:13068-13072(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL021531 Genomic DNA. Translation: CAA16492.1.

3D structure databases

ProteinModelPortalO93434.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING31033.ENSTRUP00000016600.

Proteomic databases

PRIDEO93434.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG271367.
InParanoidO93434.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRCN1_TAKRU
AccessionPrimary (citable) accession number: O93434
Entry history
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: November 1, 1998
Last modified: November 13, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families