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O93434

- RCN1_TAKRU

UniProt

O93434 - RCN1_TAKRU

Protein

Reticulocalbin-1

Gene

rcn1

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Nov 1998)
      Previous versions | rss
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    • Comment

    Functioni

    May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi83 – 94121; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi119 – 130122PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi170 – 181123; possibly ancestralPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi207 – 218124PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi248 – 259125PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi284 – 295126PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Reticulocalbin-1
    Gene namesi
    Name:rcn1
    OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
    Taxonomic identifieri31033 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
    ProteomesiUP000005226: Unplaced

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 322303Reticulocalbin-1PRO_0000004147Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiO93434.

    Interactioni

    Protein-protein interaction databases

    STRINGi31033.ENSTRUP00000016600.

    Structurei

    3D structure databases

    ProteinModelPortaliO93434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini70 – 10536EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini106 – 14136EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini157 – 19236EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini194 – 22936EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini235 – 27036EF-hand 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 30636EF-hand 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi319 – 3224Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the CREC family.Curated
    Contains 6 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG271367.
    InParanoidiO93434.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR027241. Rcn1.
    [Graphical view]
    PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O93434-1 [UniParc]FASTAAdd to Basket

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    MDVLGFICAV FLGTVVLHAK PTVRKDRVLY QDPELLRQAT NEDNNSFQYD    50
    HEVFLGKEES KTFDQLSPEE SKDRLSKIVD RIDGDGNSYI TTDELKAWIK 100
    RVQKRYVYEN VVKVWADYDL NKDNKISWEE YKQATYGYYL SNPEEFDETT 150
    DQFSFKKMLP RDERRFKRAD LDGDSAANRE EFTSFLHPEE FEHMKDIVVL 200
    ETLEDIDKNS DGHVDEDEYI ADMFAHEDRG PEPEWVKTER EQFSDFRDLN 250
    KDGKMDLDEI RHWIMPQDYD HAQAEARHLV YESDKDKDQM LTKEEILDNW 300
    NMFVGSQATN YGEDLTRNHD EL 322
    Length:322
    Mass (Da):38,207
    Last modified:November 1, 1998 - v1
    Checksum:i85F99C053AC34C5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021531 Genomic DNA. Translation: CAA16492.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL021531 Genomic DNA. Translation: CAA16492.1 .

    3D structure databases

    ProteinModelPortali O93434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 31033.ENSTRUP00000016600.

    Proteomic databases

    PRIDEi O93434.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG271367.
    InParanoidi O93434.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR027241. Rcn1.
    [Graphical view ]
    PANTHERi PTHR10827:SF17. PTHR10827:SF17. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 6 hits.
    PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13."
      Miles C., Elgar G., Coles E., Kleinjan D.J., Van Heyningen V., Hastie N.
      Proc. Natl. Acad. Sci. U.S.A. 95:13068-13072(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiRCN1_TAKRU
    AccessioniPrimary (citable) accession number: O93434
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: November 1, 1998
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3