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Protein

Reticulocalbin-1

Gene

rcn1

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi83 – 94121; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi119 – 130122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi170 – 181123; possibly ancestralPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi207 – 218124PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi248 – 259125PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi284 – 295126PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-1
Gene namesi
Name:rcn1
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
ProteomesiUP000005226 Componenti: Unplaced

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 322303Reticulocalbin-1PRO_0000004147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiO93434.

Interactioni

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000016600.

Structurei

3D structure databases

ProteinModelPortaliO93434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini70 – 10536EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini106 – 14136EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 19236EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini194 – 22936EF-hand 4PROSITE-ProRule annotationAdd
BLAST
Domaini235 – 27036EF-hand 5PROSITE-ProRule annotationAdd
BLAST
Domaini271 – 30636EF-hand 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi319 – 3224Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG271367.
InParanoidiO93434.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93434-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLGFICAV FLGTVVLHAK PTVRKDRVLY QDPELLRQAT NEDNNSFQYD
60 70 80 90 100
HEVFLGKEES KTFDQLSPEE SKDRLSKIVD RIDGDGNSYI TTDELKAWIK
110 120 130 140 150
RVQKRYVYEN VVKVWADYDL NKDNKISWEE YKQATYGYYL SNPEEFDETT
160 170 180 190 200
DQFSFKKMLP RDERRFKRAD LDGDSAANRE EFTSFLHPEE FEHMKDIVVL
210 220 230 240 250
ETLEDIDKNS DGHVDEDEYI ADMFAHEDRG PEPEWVKTER EQFSDFRDLN
260 270 280 290 300
KDGKMDLDEI RHWIMPQDYD HAQAEARHLV YESDKDKDQM LTKEEILDNW
310 320
NMFVGSQATN YGEDLTRNHD EL
Length:322
Mass (Da):38,207
Last modified:November 1, 1998 - v1
Checksum:i85F99C053AC34C5C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021531 Genomic DNA. Translation: CAA16492.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021531 Genomic DNA. Translation: CAA16492.1.

3D structure databases

ProteinModelPortaliO93434.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000016600.

Proteomic databases

PRIDEiO93434.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG271367.
InParanoidiO93434.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13."
    Miles C., Elgar G., Coles E., Kleinjan D.J., Van Heyningen V., Hastie N.
    Proc. Natl. Acad. Sci. U.S.A. 95:13068-13072(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiRCN1_TAKRU
AccessioniPrimary (citable) accession number: O93434
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: November 1, 1998
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.