O93434 (RCN1_TAKRU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Reticulocalbin-1

Gene names

Name:

rcn1

Organism

Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) [Reference proteome]

Taxonomic identifier

31033 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Tetraodontiformes › Tetraodontoidei › Tetradontoidea › Tetraodontidae › Takifugu

Protein attributes

Sequence length	322 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment By similarity.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the CREC family. Contains 6 EF-hand domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Ligand	Calcium Metal-binding
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 322	303	Reticulocalbin-1		PRO_0000004147
Regions
	Domain	70 – 105	36	EF-hand 1
	Domain	106 – 141	36	EF-hand 2
	Domain	157 – 192	36	EF-hand 3
	Domain	194 – 229	36	EF-hand 4
	Domain	235 – 270	36	EF-hand 5
	Domain	271 – 306	36	EF-hand 6
	Calcium binding	83 – 94	12	1; possibly ancestral Potential
	Calcium binding	119 – 130	12	2 Potential
	Calcium binding	170 – 181	12	3; possibly ancestral Potential
	Calcium binding	207 – 218	12	4 Potential
	Calcium binding	248 – 259	12	5 Potential
	Calcium binding	284 – 295	12	6 Potential
	Motif	319 – 322	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	44	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	O93434 [UniParc]. Last modified November 1, 1998. Version 1. Checksum: 85F99C053AC34C5C	FASTA	322	38,207
	10 20 30 40 50 60 MDVLGFICAV FLGTVVLHAK PTVRKDRVLY QDPELLRQAT NEDNNSFQYD HEVFLGKEES 70 80 90 100 110 120 KTFDQLSPEE SKDRLSKIVD RIDGDGNSYI TTDELKAWIK RVQKRYVYEN VVKVWADYDL 130 140 150 160 170 180 NKDNKISWEE YKQATYGYYL SNPEEFDETT DQFSFKKMLP RDERRFKRAD LDGDSAANRE 190 200 210 220 230 240 EFTSFLHPEE FEHMKDIVVL ETLEDIDKNS DGHVDEDEYI ADMFAHEDRG PEPEWVKTER 250 260 270 280 290 300 EQFSDFRDLN KDGKMDLDEI RHWIMPQDYD HAQAEARHLV YESDKDKDQM LTKEEILDNW 310 320 NMFVGSQATN YGEDLTRNHD EL

References

[1]

"Complete sequencing of the Fugu WAGR region from WT1 to PAX6: dramatic compaction and conservation of synteny with human chromosome 11p13." Miles C., Elgar G., Coles E., Kleinjan D.J., Van Heyningen V., Hastie N. Proc. Natl. Acad. Sci. U.S.A. 95:13068-13072(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL021531 Genomic DNA. Translation: CAA16492.1.
3D structure databases
ProteinModelPortal	O93434.
ModBase	Search...
Protein-protein interaction databases
STRING	31033.ENSTRUP00000016600.
Proteomic databases
PRIDE	O93434.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG271367.
InParanoid	O93434.
OrthoDB	EOG42RD7R.
Family and domain databases
Gene3D	1.10.238.10. 2 hits.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR027241. Rcn1. [Graphical view]
PANTHER	PTHR10827:SF17. PTHR10827:SF17. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. [Graphical view]
SMART	SM00054. EFh. 4 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 6 hits. PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RCN1_TAKRU

Accession

Primary (citable) accession number: O93434

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	November 1, 1998
Last modified:	May 1, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program