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Protein
Submitted name:

Caspase-3

Gene

CASP3

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseUniRule annotationSAAS annotation

Enzyme and pathway databases

BRENDAi3.4.22.56. 1306.
ReactomeiR-GGA-111459. Activation of caspases through apoptosome-mediated cleavage.
R-GGA-111465. Apoptotic cleavage of cellular proteins.
R-GGA-2028269. Signaling by Hippo.
R-GGA-211227. Activation of DNA fragmentation factor.
R-GGA-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-GGA-351906. Apoptotic cleavage of cell adhesion proteins.

Protein family/group databases

MEROPSiC14.003.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-3Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CASP3Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

  • cell Source: AgBase
  • cytoplasm Source: GO_Central
  • cytosol Source: Ensembl
  • nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Keywords - PTMi

ZymogenUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017288.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 175125CASPASE_P20InterPro annotationAdd
BLAST
Domaini190 – 28192CASPASE_P10InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
KOiK02187.
OMAiHSENDCF.
OrthoDBiEOG7TTQ7K.
TreeFamiTF102023.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR015470. Caspase_3.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PANTHERiPTHR10454:SF30. PTHR10454:SF30. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93417-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTDIKDGPR SGEDVSDARS FPGSKGMNLP ASKSVDSGIL PDDSYRMDYP
60 70 80 90 100
EIGVCVIINN KNFHRDTGLS SRSGTDADAA SVREVFMKLG YKVKLNNDLS
110 120 130 140 150
SRDIFKLLKN VSEEDHSKRS SFVCVLLSHG DEGLFYGTDG PLELKVLTSL
160 170 180 190 200
FRGDKCRSLA GKPKLFFIQA CRGTELDSGI EADSGPDETV CQKIPVEADF
210 220 230 240 250
LYAYSTAPGY YSWRNAAEGS WFIQSLCRML KEHARKLELM QILTRVNRRV
260 270 280
AEYESCSTRQ DFNAKKQIPC IVSMLTKEFY FPC
Length:283
Mass (Da):31,675
Last modified:November 1, 1998 - v1
Checksum:i161242DDEFD4DC4F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004284 Genomic DNA. No translation available.
AF083029 mRNA. Translation: AAC32602.1.
RefSeqiNP_990056.1. NM_204725.1.
XP_015131608.1. XM_015276122.1.
XP_015131609.1. XM_015276123.1.
UniGeneiGga.4346.

Genome annotation databases

EnsembliENSGALT00000017308; ENSGALP00000017288; ENSGALG00000010638.
ENSGALT00000045406; ENSGALP00000042835; ENSGALG00000010638.
GeneIDi395476.
KEGGigga:395476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN03004284 Genomic DNA. No translation available.
AF083029 mRNA. Translation: AAC32602.1.
RefSeqiNP_990056.1. NM_204725.1.
XP_015131608.1. XM_015276122.1.
XP_015131609.1. XM_015276123.1.
UniGeneiGga.4346.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017288.

Protein family/group databases

MEROPSiC14.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000017308; ENSGALP00000017288; ENSGALG00000010638.
ENSGALT00000045406; ENSGALP00000042835; ENSGALG00000010638.
GeneIDi395476.
KEGGigga:395476.

Organism-specific databases

CTDi836.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
KOiK02187.
OMAiHSENDCF.
OrthoDBiEOG7TTQ7K.
TreeFamiTF102023.

Enzyme and pathway databases

BRENDAi3.4.22.56. 1306.
ReactomeiR-GGA-111459. Activation of caspases through apoptosome-mediated cleavage.
R-GGA-111465. Apoptotic cleavage of cellular proteins.
R-GGA-2028269. Signaling by Hippo.
R-GGA-211227. Activation of DNA fragmentation factor.
R-GGA-264870. Caspase-mediated cleavage of cytoskeletal proteins.
R-GGA-351906. Apoptotic cleavage of cell adhesion proteins.

Miscellaneous databases

NextBioi20815557.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR015470. Caspase_3.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A_HD.
[Graphical view]
PANTHERiPTHR10454:SF30. PTHR10454:SF30. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Caspase-3 and -6 expression and enzyme activity in hen granulosa cells."
    Johnson A.L., Bridgham J.T.
    Biol. Reprod. 62:589-598(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
    International Chicken Genome Sequencing Consortium
    Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A.
    , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
    Nature 432:695-716(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Red jungle fowlImported.
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.
  4. Ensembl
    Submitted (MAY-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: Red jungle fowlImported.

Entry informationi

Entry nameiO93417_CHICK
AccessioniPrimary (citable) accession number: O93417
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.