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Protein
Submitted name:

Caspase-6

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331UniRule annotation
Active sitei175 – 1751UniRule annotation

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: AgBase

GO - Biological processi

Complete GO annotation...

Protein family/group databases

MEROPSiC14.005.

Names & Taxonomyi

Protein namesi
Submitted name:
Caspase-6Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

PTM / Processingi

Proteomic databases

PaxDbiO93415.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019870.

Structurei

3D structure databases

ProteinModelPortaliO93415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 179125CASPASE_P20InterPro annotationAdd
BLAST
Domaini207 – 30195CASPASE_P10InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
KOiK04396.
PhylomeDBiO93415.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93415-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAERRPAA GRVQLDSKPT PTTTADGNQN ITEVDAFDKR RTFDPAEQYK
60 70 80 90 100
MNHQRRGVAL IFNHEHFFWH LRLPDRRGTL ADRNNLKRSL TDLGFEVRIF
110 120 130 140 150
DDLKAEDVLK KVFEASRDDY SNADCFVCVF LSHGENDHVY AYDAQIKIET
160 170 180 190 200
ITNMFRGDKC QSLVGKPKIF IIQACRGDKH DDPVLVQDSV DSKDETTVNQ
210 220 230 240 250
TEVDAAGVYT LPAGADFIMC YSVAQGYFSH RETVNGSWYI QDLCEALGKH
260 270 280 290 300
GSSLEFTELL TVVNRKVSHR KVDICRDINA IGKKQIPCFA SMLTKKLYFH

PKSK
Length:304
Mass (Da):34,534
Last modified:November 1, 1998 - v1
Checksum:i51CE31EBCAAE7383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082329 mRNA. Translation: AAC32378.1.
AF469049 Genomic DNA. Translation: AAL82386.1.
RefSeqiNP_990057.1. NM_204726.1.
UniGeneiGga.2960.

Genome annotation databases

GeneIDi395477.
KEGGigga:395477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082329 mRNA. Translation: AAC32378.1.
AF469049 Genomic DNA. Translation: AAL82386.1.
RefSeqiNP_990057.1. NM_204726.1.
UniGeneiGga.2960.

3D structure databases

ProteinModelPortaliO93415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019870.

Protein family/group databases

MEROPSiC14.005.

Proteomic databases

PaxDbiO93415.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395477.
KEGGigga:395477.

Organism-specific databases

CTDi839.

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
HOGENOMiHOG000231878.
HOVERGENiHBG050802.
KOiK04396.
PhylomeDBiO93415.

Miscellaneous databases

NextBioi20815558.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR017350. Pept_C14A_CASP1-typ.
IPR015917. Pept_C14A_HD.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF52129. SSF52129. 1 hit.
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Caspase-3 and -6 expression and enzyme activity in hen granulosa cells."
    Johnson A.L., Bridgham J.T.
    Biol. Reprod. 62:589-598(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation."
    Ruchaud S., Korfali N., Villa P., Kottke T.J., Dingwall C., Kaufmann S.H., Earnshaw W.C.
    EMBO J. 21:1967-1977(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO93415_CHICK
AccessioniPrimary (citable) accession number: O93415
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.