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Protein

Tyrosine-protein kinase

Gene

hck

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:hckImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252726. hck.

Structurei

3D structure databases

ProteinModelPortaliO93411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 111SH3InterPro annotationAdd BLAST61
Domaini117 – 210SH2InterPro annotationAdd BLAST94
Domaini231 – 485Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation
Contains 1 SH2 domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation
Contains 1 protein kinase domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG008761.
KOiK08893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKDSN TTGKSLGPPE STQTHYVKDP TSTVTMTKPE RSSKHPREEG
60 70 80 90 100
QEEVVLLALY DYDGVHPGDL TFRKGDHLLL KKESGEWWEA CLISTGEEGF
110 120 130 140 150
VPSNYVAYFN SLESEEWYFK GMSRKEAERQ LLSPVNKSGA FMIRDSETMK
160 170 180 190 200
GCFSLSVRDS GDTVKHYKIR TLDDGGFFIS TRIPFPSLPE LVRHYQGKVD
210 220 230 240 250
GLCQCLTIPC QTVRPEKPWE KDAWEIPRES LSLQKKLGAG QFGDVWLAMY
260 270 280 290 300
NGHTKVAVKT MKPGSMSPGA FLEEANLMKS LQHDRLVRLH AVVTQGEPIY
310 320 330 340 350
IITEYMQKGS LLDFLKSEEG SDQPLIQLID FSAQIAEGMW FIEQRNYIHR
360 370 380 390 400
DLRAANCLVS ETLLCKIADF GLARVIEDSE YTAREGTKFP IKWTSLEAAN
410 420 430 440 450
YGSFTIKSDV WSFGVLLTEI ITYGRTPYPG MSNSEVITAL ERGYRMPCPS
460 470 480 490
TCPKELYSIM LQCWQQDPEQ RPTFEYLQSI LEDFFTATET QYQAQP
Length:496
Mass (Da):56,275
Last modified:November 1, 1998 - v1
Checksum:i96223A6F99689965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081803 mRNA. Translation: AAC31209.1.
RefSeqiNP_001079150.1. NM_001085681.1.
UniGeneiXl.294.

Genome annotation databases

GeneIDi373700.
KEGGixla:373700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081803 mRNA. Translation: AAC31209.1.
RefSeqiNP_001079150.1. NM_001085681.1.
UniGeneiXl.294.

3D structure databases

ProteinModelPortaliO93411.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373700.
KEGGixla:373700.

Organism-specific databases

CTDi3055.
XenbaseiXB-GENE-6252726. hck.

Phylogenomic databases

HOVERGENiHBG008761.
KOiK08893.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO93411_XENLA
AccessioniPrimary (citable) accession number: O93411
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.