Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tyrosine-protein kinase

Gene

hck

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

Keywordsi

Molecular functionKinase, ReceptorImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesi
Name:hckImported
OrganismiXenopus laevis (African clawed frog)Imported
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6252726. hck.

Structurei

3D structure databases

ProteinModelPortaliO93411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 111SH3InterPro annotationAdd BLAST61
Domaini117 – 210SH2InterPro annotationAdd BLAST94
Domaini231 – 485Protein kinaseInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotationSAAS annotation

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG008761.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR036860. SH2_dom_sf.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiView protein in SMART
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

O93411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCIKSKDSN TTGKSLGPPE STQTHYVKDP TSTVTMTKPE RSSKHPREEG
60 70 80 90 100
QEEVVLLALY DYDGVHPGDL TFRKGDHLLL KKESGEWWEA CLISTGEEGF
110 120 130 140 150
VPSNYVAYFN SLESEEWYFK GMSRKEAERQ LLSPVNKSGA FMIRDSETMK
160 170 180 190 200
GCFSLSVRDS GDTVKHYKIR TLDDGGFFIS TRIPFPSLPE LVRHYQGKVD
210 220 230 240 250
GLCQCLTIPC QTVRPEKPWE KDAWEIPRES LSLQKKLGAG QFGDVWLAMY
260 270 280 290 300
NGHTKVAVKT MKPGSMSPGA FLEEANLMKS LQHDRLVRLH AVVTQGEPIY
310 320 330 340 350
IITEYMQKGS LLDFLKSEEG SDQPLIQLID FSAQIAEGMW FIEQRNYIHR
360 370 380 390 400
DLRAANCLVS ETLLCKIADF GLARVIEDSE YTAREGTKFP IKWTSLEAAN
410 420 430 440 450
YGSFTIKSDV WSFGVLLTEI ITYGRTPYPG MSNSEVITAL ERGYRMPCPS
460 470 480 490
TCPKELYSIM LQCWQQDPEQ RPTFEYLQSI LEDFFTATET QYQAQP
Length:496
Mass (Da):56,275
Last modified:November 1, 1998 - v1
Checksum:i96223A6F99689965
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081803 mRNA. Translation: AAC31209.1.
RefSeqiNP_001079150.1. NM_001085681.1.
UniGeneiXl.294.

Genome annotation databases

GeneIDi373700.

Similar proteinsi

Entry informationi

Entry nameiO93411_XENLA
AccessioniPrimary (citable) accession number: O93411
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 22, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)