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Protein
Submitted name:

Fibronectin 1a isoform 1

Gene

fn1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • integrin binding Source: ZFIN

GO - Biological processi

  • adrenal gland development Source: ZFIN
  • cardioblast migration to the midline involved in heart rudiment formation Source: ZFIN
  • cell migration involved in sprouting angiogenesis Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • endocardial cell differentiation Source: ZFIN
  • establishment of epithelial cell apical/basal polarity Source: ZFIN
  • heart development Source: ZFIN
  • heart field specification Source: ZFIN
  • heart jogging Source: ZFIN
  • heart morphogenesis Source: ZFIN
  • lens fiber cell morphogenesis Source: ZFIN
  • lens morphogenesis in camera-type eye Source: ZFIN
  • single organismal cell-cell adhesion Source: ZFIN
  • somite specification Source: ZFIN
  • somitogenesis Source: ZFIN
  • ventricular system development Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Fibronectin 1a isoform 1Imported
Gene namesi
Name:fn1aImported
Synonyms:fn1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-000426-1. fn1a.

Subcellular locationi

GO - Cellular componenti

  • interstitial matrix Source: ZFIN
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500416089422 – 2478Sequence analysisAdd BLAST2457

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiO93406.

Interactioni

GO - Molecular functioni

  • integrin binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112231.

Structurei

3D structure databases

ProteinModelPortaliO93406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 83Fibronectin type-IInterPro annotationAdd BLAST40
Domaini88 – 131Fibronectin type-IInterPro annotationAdd BLAST44
Domaini132 – 175Fibronectin type-IInterPro annotationAdd BLAST44
Domaini177 – 221Fibronectin type-IInterPro annotationAdd BLAST45
Domaini222 – 266Fibronectin type-IInterPro annotationAdd BLAST45
Domaini301 – 340Fibronectin type-IInterPro annotationAdd BLAST40
Domaini351 – 399Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini411 – 459Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini464 – 508Fibronectin type-IInterPro annotationAdd BLAST45
Domaini513 – 555Fibronectin type-IInterPro annotationAdd BLAST43
Domaini556 – 599Fibronectin type-IInterPro annotationAdd BLAST44
Domaini607 – 706Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini711 – 808Fibronectin type-IIIInterPro annotationAdd BLAST98
Domaini809 – 900Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini907 – 996Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini997 – 1086Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1087 – 1173Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1174 – 1265Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini1267 – 1357Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1358 – 1453Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1454 – 1539Fibronectin type-IIIInterPro annotationAdd BLAST86
Domaini1540 – 1633Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1634 – 1724Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1725 – 1813Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1814 – 1907Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini1908 – 1996Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1999 – 2095Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini2193 – 2286Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini2295 – 2339Fibronectin type-IInterPro annotationAdd BLAST45
Domaini2340 – 2382Fibronectin type-IInterPro annotationAdd BLAST43
Domaini2384 – 2424Fibronectin type-IInterPro annotationAdd BLAST41

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Family and domain databases

CDDicd00062. FN2. 2 hits.
cd00063. FN3. 16 hits.
Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 11 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 11 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93406-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGGPLGTAL AVALLACAVQ CMPKGTGKHK RQAQEHSVSS VSQDGCVMDG
60 70 80 90 100
QFYGAGEQWE RIYLGSTLLC TCHGVSKIEC KSKPDAEETC YDKVNSRSYR
110 120 130 140 150
VGETYERPKD GMIWDCTCIG SARGKISCTI ANRCHEGGHS YKIGDTWQRP
160 170 180 190 200
HDTGDYMLEC VCLGNGKGEW TCKPVADACY DNTAGTSYMV GETWEKPYQG
210 220 230 240 250
WMIVDCTCLG EGSGRITCTS RNRCNDQDTR TSYRIGDTWS KTDSRGHVLQ
260 270 280 290 300
CLCTGNGRGE WKCERHASLH TTSLGTGSRV VTNVQPAVYH PQGVPEHPVE
310 320 330 340 350
GSCLTEAGVS YAPGMRWSKA QGSKQMLCTC LGNGVSCEES ESQSQVYGGT
360 370 380 390 400
SGGEPCAFPF VFMGETFYSC TSEGRNDGQL WCSTSSDFEK DYKYSFCTSN
410 420 430 440 450
NVVVTTRGGN SNGALCQFPF LYNGRNYTDC TADGRRDGMK WCGTTYNFDK
460 470 480 490 500
EQRFGFCPMA AHEEVCTTNE GVMYRVGDQW DRRHDVLGHM MRCTCVGNGR
510 520 530 540 550
GEWSCIAYSQ LKDQCIVDNL TYEVNQTFTK RHDEGYTMNC TCFGQGRGRW
560 570 580 590 600
KCDAIDQCQE PETRVFYQIG ESWDKLIQGI HYRCYCYGNG IGELSCEPQH
610 620 630 640 650
SISGGHRPVQ VIISEAGNQP NSHPIQWNAP ASAHITQYIL KWRPKNTHIQ
660 670 680 690 700
WMEVTIPGHV NSYTIAGLKP GVTYEGQLIS ILRFGRRETT RFDFSTVHGS
710 720 730 740 750
LETSEGETTQ PPRMVDTSES VTEITSSSFV ISWVSASDTV SGFRVEYELS
760 770 780 790 800
EEGGQTGQPM ILDLPHSATS VNISELLPGR KYTVNVYEVT GEGEPNLILT
810 820 830 840 850
TSQTTAPDAP SDHEVEDVAD TSIRISWSKP LAPITGYRVV YTPSEEGSSG
860 870 880 890 900
SVELNLPEHS TSLTLGDLRP GVLYNISIFS VEENQESEPV FVQVTTAGEP
910 920 930 940 950
LAEEVPSPTD LQFYEVSDSK ITITWTSPSS EVSGYRVSVG EVGPDGFDEE
960 970 980 990 1000
VLSVTQNAYA EITHLQPGTL YRFFIFSLKS GEESEPLVGE QATKPDPQTD
1010 1020 1030 1040 1050
IYFSNITEDS AVIVWLPPTA QITGYRLFLT VEGSNPNSCV FQPSGRSYHP
1060 1070 1080 1090 1100
SLNLQPDTEY SATLHAERGN VLSEGSIATF ATTPPMGNAP YFSTDVTDTS
1110 1120 1130 1140 1150
IIVSWSPLPK IGYKLTVRPS QGGEAPRDVT SELGSVLISG LTPGVEYTYS
1160 1170 1180 1190 1200
VQPVISGQEH GNPITRRVVT PLSPPTDLNL ESNPNTGKLT VQWNDANIPD
1210 1220 1230 1240 1250
ITGYRVTCTP TKGQQGNSLE EFVKAGQNSC TLENLSPGVE YNVSVFTVKD
1260 1270 1280 1290 1300
DMESVPVFTT VTPDVPKITD LSFINVTDST IGLSWSPLNS TAVTGYRITV
1310 1320 1330 1340 1350
LAAGDSVPIF VEFVEPTTGF YTVHGLEPGI DYDITVTTVT ENGESEPITI
1360 1370 1380 1390 1400
TQQTAVPAPY GLSFGEVTAD TMLVTWKAPQ VPKSSDINQY IIRYHPVDED
1410 1420 1430 1440 1450
DETTERTVEG SENFVVLRHL VPNTEYLVSV ICVYEGREGS PAIGPRELFL
1460 1470 1480 1490 1500
MPCCLQFSDV GTTSFTVRWQ APRAIISGYR IRYQMTSGGR AKEERLPPSR
1510 1520 1530 1540 1550
SHFTLTGLTP ETEYSISVYA VSGSRDSLPL TGTQSTISDA PTDLEVISST
1560 1570 1580 1590 1600
PTSITVRWDA PSVTVRYYRI THGESGGSDA PLEFMVPGSQ STATIEDLRP
1610 1620 1630 1640 1650
GTDYTITVYA VTGRGDSPAS STPIHVKHRT DIDSPSQMEV TDVKDNTITV
1660 1670 1680 1690 1700
RWTPAAGPIS RYRVNATPLT GEGPVLHAET TSDHTEITFS GLMPAVEYSI
1710 1720 1730 1740 1750
KVYALGQDGE SLPLVENVVT TVDKPKDLSF TDVESSSMRI SWDSPDGVVS
1760 1770 1780 1790 1800
SYRVLYYSPE EGERELFPAP HGDDESAVLH GLRPGTEYTV KVIALHDQSP
1810 1820 1830 1840 1850
STALVGTQTT GIPGPTRLQF SQVGPTSFTV SWSSSDASLT GYRVAVSPKS
1860 1870 1880 1890 1900
KSGPTKEENI TPDSTEFHAT GLMPGTDYEV EVYGVKNSLT SPRVKGEITT
1910 1920 1930 1940 1950
PDNISPPRRV RISNVKDSSI TLTWRSKTEA ISGFLVEATP TMGGHNPIQR
1960 1970 1980 1990 2000
TIEPDSRTYT IAGLEPGTNY KINIYTLNGN SRSEPFTLTA TTAKPVISPP
2010 2020 2030 2040 2050
TNLHFTSLAS TSISFTWEPP RSTITGYYVT YEEAGGIPKE LTPRPQAART
2060 2070 2080 2090 2100
FASISGLIPG TEYIIKIVAL NGAQRSTPLI GKARTQLEIE QLPPQLPNPS
2110 2120 2130 2140 2150
RPHLEVLDVP EDNDNFNNHV HVLGPNRHNT LGQQGQHIYT EYQSFNLGNN
2160 2170 2180 2190 2200
GQQPHHPNHG EPLVYIPLPG ADGQRVPVVK VNEGQEAGFP FGGLFNETNL
2210 2220 2230 2240 2250
PQESQTQTTI VWQPVPHTSE YVVWCDPITE INEKSFQMRL PGTSTSATLI
2260 2270 2280 2290 2300
GLTSGASYNV LVESVNGDQK QKVLQDVVTV GNSVPGAGVI PTGRDVCYDS
2310 2320 2330 2340 2350
FTATYHEVNT EWERMSETGF KLWCKCLGLG SGHFRCDSSK WCHDSGHNYR
2360 2370 2380 2390 2400
IGEKWDRRAE NGHMMSCTCL GNGKGEFKCE PHESTCYDEG KLYQVGNQWQ
2410 2420 2430 2440 2450
KEYLGAICTC TCYGGQQGWR CENCRRPGAE VDADLIQPPV RTDAFDRYRE
2460 2470
NALRKLNIQC PIECLRPDLL ADAHSPHD
Length:2,478
Mass (Da):271,654
Last modified:November 1, 1998 - v1
Checksum:iA03475C55A385750
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081128 mRNA. Translation: AAC31947.1.
UniGeneiDr.51894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF081128 mRNA. Translation: AAC31947.1.
UniGeneiDr.51894.

3D structure databases

ProteinModelPortaliO93406.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112231.

Proteomic databases

PaxDbiO93406.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-000426-1. fn1a.

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.

Family and domain databases

CDDicd00062. FN2. 2 hits.
cd00063. FN3. 16 hits.
Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 11 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 11 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO93406_DANRE
AccessioniPrimary (citable) accession number: O93406
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.