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O93403

- CHST3_TORCA

UniProt

O93403 - CHST3_TORCA

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Protein
Carbohydrate sulfotransferase 3
Gene
CHST3, NSIST
Organism
Torpedo californica (Pacific electric ray)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices By similarity.

Catalytic activityi

3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi106 – 1127PAPS By similarity
Nucleotide bindingi266 – 2749PAPS By similarity

GO - Molecular functioni

  1. chondroitin 6-sulfotransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Carbohydrate metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Nervous system involved sulfotransferase
Gene namesi
Name:CHST3
Synonyms:NSIST
OrganismiTorpedo californica (Pacific electric ray)
Taxonomic identifieri7787 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTorpedo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44Cytoplasmic Reviewed prediction
Transmembranei5 – 2117Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini22 – 441420Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Carbohydrate sulfotransferase 3
PRO_0000085192Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi58 – 581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi221 – 2211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

In electric organ, it is moderately expressed in spinal cord and electric lobe and undetectable in non-neural tissues. Expressed in a punctate distribution in the innervated portion of electrocytes. In the CNS, it is localized within the somas of motor neurons and neurons of the electromotor nucleus.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93403.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG106811.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view]
PfamiPF00685. Sulfotransfer_1. 1 hit.
[Graphical view]
PIRSFiPIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

O93403-1 [UniParc]FASTAAdd to Basket

« Hide

MKMRSKYAII LFFVVALVII EKERNIISRV SDKFTLKFPH AESVAPNNTI    50
SARSLTKNNS LLANSVAAVW KLLKARRSYS SLQSAASSDV RKVLKGRKHL 100
LLMATTRTGS SFVGEFFNQN NDIFYLFEPL WHVEKTVTFE PGGMNAVASS 150
IIYRDVVQQL MLCDLYTLEN FLFPMADRHL TGILFRRGSS KSLCEGEVCT 200
PPKKGGTEKF PCRLRDCGLL NLTLATQACL QKQHVAIKTV PLRQLEFLRP 250
LVEDFRINLK IIQLVRDPRA VLASRMVAFP SKYNAWKKWA NEGRVPDDDE 300
VGKIRGNCEN LRATAQLGIS QPPWLKDRFL LMRYEDIALE PVKRAQEMYR 350
FSGIPMTPEV KKWIYENTQV SKASNNIYST HKISSEQFEK WRLGLPFKIA 400
RVVQQVCEPA MKLFGYKLVK DAATLANRSA SLLENRNFWI T 441
Length:441
Mass (Da):50,393
Last modified:November 1, 1998 - v1
Checksum:i993B8B858743BA53
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079875 mRNA. Translation: AAC28491.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF079875 mRNA. Translation: AAC28491.1 .

3D structure databases

ProteinModelPortali O93403.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG106811.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR016469. Carbohydrate_sulfotransferase.
IPR027417. P-loop_NTPase.
IPR000863. Sulfotransferase_dom.
[Graphical view ]
Pfami PF00685. Sulfotransfer_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005883. Carbohydrate_sulfotransferase. 1 hit.
SUPFAMi SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Expression cloning and characterization of NSIST, a novel sulfotransferase expressed by a subset of neurons and postsynaptic targets."
    Nastuk M.A., Davis S., Yancopoulos G.D., Fallon J.R.
    J. Neurosci. 18:7167-7177(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiCHST3_TORCA
AccessioniPrimary (citable) accession number: O93403
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1998
Last modified: April 16, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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