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Protein
Submitted name:

Neprilysin

Gene

NEP1

Organism
Perca flavescens (American yellow perch) (Morone flavescens)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Protein family/group databases

MEROPSiM13.001.

Names & Taxonomyi

Protein namesi
Submitted name:
NeprilysinImported
Gene namesi
Name:NEP1Imported
OrganismiPerca flavescens (American yellow perch) (Morone flavescens)Imported
Taxonomic identifieri8167 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaPerciformesPercoideiPercidaePercinaePerca

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei48 – 69HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliO93394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 503Peptidase_M13_NInterPro annotationAdd BLAST405
Domaini563 – 769Peptidase_M13InterPro annotationAdd BLAST207

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG005554.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR029727. MME/CD10/NEP.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PTHR11733:SF114. PTHR11733:SF114. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

O93394-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIYIIDRKF PDTSGELIQP AAEAGDLRMM ETNPPKSAKK PRWTSLEVGL
60 70 80 90 100
TTIVSLLFIV IVALIILFAT QKTDEICTTG DCTQSASRLI ENMDDSVDPC
110 120 130 140 150
DNFYQYACGG WLKKNIIPET SSRYSTFDIL RDELEVILKG VLEKTDEGEA
160 170 180 190 200
TLSTRAKTLY KSCTNESLIE LRGGAPLLDM LPDVFEWPVA VDNWETNYGK
210 220 230 240 250
TWRLEDVIAK LNEKYGTQLL VNFFVGTDDR DSNSYIIHFD QQTNLGLLSR
260 270 280 290 300
DYYACTGPYA EACRAYEKFM IDLAKLIRID RGLNISETDI REEVKRVMDL
310 320 330 340 350
ERDIANATDT PEDRNNPVLL YNKMELGDLN ANFTLEVESQ VFDWSYFTAK
360 370 380 390 400
IMDTVNISVP DTEKVINYSP NYYRRLNLIL ARYNKRDLQN YMVWRFAMNM
410 420 430 440 450
VVGLSRSYRD TRKAFRKALS GTTSEAAVWR QCALYVNNNM DNAVGRLYVQ
460 470 480 490 500
EAFSEKSKEL MEEMIKDIRE VFISNLDDLT WMDAETKKAA EEKARAIRER
510 520 530 540 550
IGYSDNIKDD KYLNNEYNDL AYSAEEYFEN ILQNLEYVQK KRLRKLRVKV
560 570 580 590 600
NKEEWVTGAA VVNAFYSSSK NQIVFPAGIL QPPFFSKGQA KSLNYGGIGM
610 620 630 640 650
VIGHEITHGF DDNGRNYDKD GDLKDWWTPG STDRFLDLSK CIVNQYGNFS
660 670 680 690 700
WDLANGLHLN GNNTLGENIA DNGGIRQAYQ AYKNYVEKHG EEPSLPGINL
710 720 730 740 750
SHNQLFFLNF AQVWCGTHRP EQAVNSIKVD VHSPGKFRVL GSLQNFPEFA
760 770
KAFNCKKNSY MVPANICRVW
Length:770
Mass (Da):88,136
Last modified:November 1, 1998 - v1
Checksum:iD29F216CB041BACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077612 mRNA. Translation: AAC28366.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077612 mRNA. Translation: AAC28366.1.

3D structure databases

ProteinModelPortaliO93394.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiM13.001.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005554.

Family and domain databases

CDDicd08662. M13. 1 hit.
Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR029727. MME/CD10/NEP.
IPR000718. Peptidase_M13.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PANTHERiPTHR11733. PTHR11733. 1 hit.
PTHR11733:SF114. PTHR11733:SF114. 1 hit.
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Entry informationi

Entry nameiO93394_PERFV
AccessioniPrimary (citable) accession number: O93394
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.