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Protein

Pituitary homeobox 2

Gene

PITX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi101 – 160HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • determination of left/right symmetry Source: BHF-UCL
  • embryonic limb morphogenesis Source: BHF-UCL
  • embryonic organ morphogenesis Source: AgBase
  • heart looping Source: AgBase
  • heart morphogenesis Source: AgBase
  • positive regulation of dermatome development Source: BHF-UCL
  • positive regulation of myoblast differentiation Source: BHF-UCL
  • positive regulation of myoblast proliferation Source: BHF-UCL
  • positive regulation of myotome development Source: BHF-UCL
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • response to retinoic acid Source: AgBase

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox 2
Alternative name(s):
Homeobox protein PITX2
Short name:
cPITX2
Paired-like homeodomain transcription factor 2
Gene namesi
Name:PITX2
Synonyms:PTX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492261 – 333Pituitary homeobox 2Add BLAST333

Proteomic databases

PaxDbiO93385

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036884

Structurei

3D structure databases

ProteinModelPortaliO93385
SMRiO93385
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi295 – 308OARPROSITE-ProRule annotationAdd BLAST14
Motifi301 – 305Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 33Poly-SerAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486 Eukaryota
ENOG410ZZ6J LUCA
HOVERGENiHBG068770
InParanoidiO93385
KOiK04686
PhylomeDBiO93385

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR016233 Homeobox_Pitx/unc30
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
PIRSFiPIRSF000563 Homeobox_protein_Pitx/Unc30, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O93385-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCMKDPLSL ERLGAGNNKL CSSSPSSSSS SSSCHHQQPA LAMATALAPG
60 70 80 90 100
QARSSLEAAK HRLEVHTISD TSSPEAAEKE KSQQGKSEDA GPEDPSKKKR
110 120 130 140 150
QRRQRTHFTS QQLQELEATF QRNRYPDMST REEIAVWTNL TEARVRVWFK
160 170 180 190 200
NRRAKWRKRE RNQQAELCKN GFGPQFNGLM QPYDDMYPGY SYNNWAAKGL
210 220 230 240 250
TSASLSTKSF PFFNSMNVNP LSSQSMFSPP NSISSMSMSS SMVPSAVTGV
260 270 280 290 300
PGSGLNSLNN LNNLSNPSLN SAVPTPACPY APPTPPYVYR DTCNSSLASL
310 320 330
RLKAKQHSSF GYASVQNPAS NLSACQYPVD RPV
Length:333
Mass (Da):36,558
Last modified:November 1, 1998 - v1
Checksum:iFE9C68E475F5CCB5
GO
Isoform 2 (identifier: O93385-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-77: LEVHTISDTSSPEAA → MESNCRKLVSACVQL

Show »
Length:271
Mass (Da):30,330
Checksum:i9EBFAF5A7CAA4D6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234S → T in AAC18346 (Ref. 3) Curated1
Sequence conflicti292T → M in AAC18346 (Ref. 3) Curated1
Sequence conflicti317N → K in AAC18346 (Ref. 3) Curated1
Sequence conflicti328P → A in AAD46097 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022661 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_00226763 – 77LEVHT…SPEAA → MESNCRKLVSACVQL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076640 mRNA Translation: AAC27322.1
AF077092 mRNA Translation: AAD46097.1
AF063935 mRNA Translation: AAC18346.1
PIRiJW0097
RefSeqiNP_990341.1, NM_205010.1 [O93385-1]
UniGeneiGga.3398

Genome annotation databases

GeneIDi395862
KEGGigga:395862

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPITX2_CHICK
AccessioniPrimary (citable) accession number: O93385
Secondary accession number(s): O73854, Q9PWE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health