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Protein

Pituitary homeobox 2

Gene

PITX2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi101 – 160HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • determination of left/right symmetry Source: BHF-UCL
  • embryonic limb morphogenesis Source: BHF-UCL
  • embryonic organ morphogenesis Source: AgBase
  • heart looping Source: AgBase
  • heart morphogenesis Source: AgBase
  • positive regulation of dermatome development Source: BHF-UCL
  • positive regulation of myoblast differentiation Source: BHF-UCL
  • positive regulation of myoblast proliferation Source: BHF-UCL
  • positive regulation of myotome development Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • response to retinoic acid Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary homeobox 2
Alternative name(s):
Homeobox protein PITX2
Short name:
cPITX2
Paired-like homeodomain transcription factor 2
Gene namesi
Name:PITX2
Synonyms:PTX2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000492261 – 333Pituitary homeobox 2Add BLAST333

Proteomic databases

PaxDbiO93385.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036884.

Structurei

3D structure databases

ProteinModelPortaliO93385.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi295 – 308OARPROSITE-ProRule annotationAdd BLAST14
Motifi301 – 305Nuclear localization signalSequence analysis5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 33Poly-SerAdd BLAST12

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
HOVERGENiHBG068770.
InParanoidiO93385.
KOiK04686.
PhylomeDBiO93385.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR016233. Homeobox_Pitx/unc30.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PIRSFiPIRSF000563. Homeobox_protein_Pitx/Unc30. 1 hit.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: O93385-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCMKDPLSL ERLGAGNNKL CSSSPSSSSS SSSCHHQQPA LAMATALAPG
60 70 80 90 100
QARSSLEAAK HRLEVHTISD TSSPEAAEKE KSQQGKSEDA GPEDPSKKKR
110 120 130 140 150
QRRQRTHFTS QQLQELEATF QRNRYPDMST REEIAVWTNL TEARVRVWFK
160 170 180 190 200
NRRAKWRKRE RNQQAELCKN GFGPQFNGLM QPYDDMYPGY SYNNWAAKGL
210 220 230 240 250
TSASLSTKSF PFFNSMNVNP LSSQSMFSPP NSISSMSMSS SMVPSAVTGV
260 270 280 290 300
PGSGLNSLNN LNNLSNPSLN SAVPTPACPY APPTPPYVYR DTCNSSLASL
310 320 330
RLKAKQHSSF GYASVQNPAS NLSACQYPVD RPV
Length:333
Mass (Da):36,558
Last modified:November 1, 1998 - v1
Checksum:iFE9C68E475F5CCB5
GO
Isoform 2 (identifier: O93385-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-62: Missing.
     63-77: LEVHTISDTSSPEAA → MESNCRKLVSACVQL

Show »
Length:271
Mass (Da):30,330
Checksum:i9EBFAF5A7CAA4D6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234S → T in AAC18346 (Ref. 3) Curated1
Sequence conflicti292T → M in AAC18346 (Ref. 3) Curated1
Sequence conflicti317N → K in AAC18346 (Ref. 3) Curated1
Sequence conflicti328P → A in AAD46097 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022661 – 62Missing in isoform 2. 1 PublicationAdd BLAST62
Alternative sequenceiVSP_00226763 – 77LEVHT…SPEAA → MESNCRKLVSACVQL in isoform 2. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076640 mRNA. Translation: AAC27322.1.
AF077092 mRNA. Translation: AAD46097.1.
AF063935 mRNA. Translation: AAC18346.1.
PIRiJW0097.
RefSeqiNP_990341.1. NM_205010.1. [O93385-1]
UniGeneiGga.3398.

Genome annotation databases

GeneIDi395862.
KEGGigga:395862.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF076640 mRNA. Translation: AAC27322.1.
AF077092 mRNA. Translation: AAD46097.1.
AF063935 mRNA. Translation: AAC18346.1.
PIRiJW0097.
RefSeqiNP_990341.1. NM_205010.1. [O93385-1]
UniGeneiGga.3398.

3D structure databases

ProteinModelPortaliO93385.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036884.

Proteomic databases

PaxDbiO93385.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395862.
KEGGigga:395862.

Organism-specific databases

CTDi5308.

Phylogenomic databases

eggNOGiKOG0486. Eukaryota.
ENOG410ZZ6J. LUCA.
HOVERGENiHBG068770.
InParanoidiO93385.
KOiK04686.
PhylomeDBiO93385.

Miscellaneous databases

PROiO93385.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR016233. Homeobox_Pitx/unc30.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
PIRSFiPIRSF000563. Homeobox_protein_Pitx/Unc30. 1 hit.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPITX2_CHICK
AccessioniPrimary (citable) accession number: O93385
Secondary accession number(s): O73854, Q9PWE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.