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Protein

Cellular tumor antigen p53

Gene

tp53

Organism
Ictalurus punctatus (Channel catfish) (Silurus punctatus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi151ZincBy similarity1
Metal bindingi154ZincBy similarity1
Metal bindingi214ZincBy similarity1
Metal bindingi218ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi77 – 268By similarityAdd BLAST192

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Apoptosis, Cell cycle, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Cellular tumor antigen p53
Alternative name(s):
Tumor suppressor p53
Gene namesi
Name:tp53
Synonyms:p53
OrganismiIctalurus punctatus (Channel catfish) (Silurus punctatus)
Taxonomic identifieri7998 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiSiluriformesIctaluridaeIctalurus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001857191 – 376Cellular tumor antigen p53Add BLAST376

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Binds DNA as a homotetramer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95Interaction with DNABy similarity1

Structurei

3D structure databases

ProteinModelPortaliO93379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 36Transcription activation (acidic)Add BLAST36
Regioni249 – 256Interaction with DNABy similarity8
Regioni303 – 334OligomerizationAdd BLAST32
Regioni347 – 372Basic (repression of DNA-binding)Add BLAST26

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi280 – 297Bipartite nuclear localization signalBy similarityAdd BLAST18
Motifi317 – 328Nuclear export signalBy similarityAdd BLAST12

Sequence similaritiesi

Belongs to the p53 family.Curated

Phylogenomic databases

HOVERGENiHBG005201.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGNGERDTM MVEPPDSQEF AELWLRNLIV RDNSLWGKEE EIPDDLQEVP
60 70 80 90 100
CDVLLSDMLQ PQSSSSPPTS TVPVTSDYPG LLNFTLHFQE SSGTKSVTCT
110 120 130 140 150
YSPDLNKLFC QLAKTCPVLM AVSSSPPPGS VLRATAVYKR SEHVAEVVRR
160 170 180 190 200
CPHHERSNDS SDGPAPPGHL LRVEGNSRAV YQEDGNTQAH SVVVPYEPPQ
210 220 230 240 250
VGSQSTTVLY NYMCNSSCMG GMNRRPILTI ITLETQDGHL LGRRTFEVRV
260 270 280 290 300
CACPGRDRKT EESNFKKQQE PKTSGKTLTK RSMKDPPSHP EASKKSKNSS
310 320 330 340 350
SDDEIYTLQV RGKERYEFLK KINDGLELSD VVPPADQEKY RQKLLSKTCR
360 370
KERDGAAGEP KRGKKRLVKE EKCDSD
Length:376
Mass (Da):41,989
Last modified:November 1, 1998 - v1
Checksum:i1B89CD98DB3289F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074967 mRNA. Translation: AAC26824.1.
RefSeqiNP_001187005.1. NM_001200076.1.
UniGeneiIpu.5890.
Ipu.65072.

Genome annotation databases

GeneIDi100304476.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF074967 mRNA. Translation: AAC26824.1.
RefSeqiNP_001187005.1. NM_001200076.1.
UniGeneiIpu.5890.
Ipu.65072.

3D structure databases

ProteinModelPortaliO93379.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100304476.

Organism-specific databases

CTDi7157.

Phylogenomic databases

HOVERGENiHBG005201.

Family and domain databases

CDDicd08367. P53. 1 hit.
Gene3Di2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERiPTHR11447. PTHR11447. 1 hit.
PfamiPF00870. P53. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSiPR00386. P53SUPPRESSR.
SUPFAMiSSF47719. SSF47719. 1 hit.
SSF49417. SSF49417. 1 hit.
PROSITEiPS00348. P53. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP53_ICTPU
AccessioniPrimary (citable) accession number: O93379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1998
Last modified: November 2, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.