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Protein

Histone-binding protein RBBP4-A

Gene

rbbp4-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Cell cycle, DNA replication, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-binding protein RBBP4-A
Alternative name(s):
Retinoblastoma-binding protein 4-A
Short name:
RBBP-4-A
Retinoblastoma-binding protein p48-A
Gene namesi
Name:rbbp4-a
Synonyms:rbap48-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-482006. rbbp4.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 425424Histone-binding protein RBBP4-APRO_0000051190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiO93377.

Interactioni

Subunit structurei

Component of the DREAM complex (By similarity). Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin. Probably forms a large corepressor complex that contains ncor1, sin3a, hdac1-A and/or hdac1-B, hdac2, rbbp4-A and/or rbbp4-B and possibly rbbp7.By similarity

Protein-protein interaction databases

BioGridi100456. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliO93377.
SMRiO93377. Positions 7-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati122 – 16241WD 1Add
BLAST
Repeati175 – 21541WD 2Add
BLAST
Repeati225 – 26541WD 3Add
BLAST
Repeati271 – 31141WD 4Add
BLAST
Repeati315 – 35541WD 5Add
BLAST
Repeati372 – 41241WD 6Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG053236.
KOiK10752.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL
60 70 80 90 100
SDVTRPDGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS
110 120 130 140 150
EKGEFGGFGS VSGKIEIEIK ITHDGEVNRA RYMPQNPCII ATKTPTSDVL
160 170 180 190 200
VFDYTKHPSK PDPSGECNPN LRLRGHQKEG YGLSWNPNLS GNLLSASDDH
210 220 230 240 250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ
260 270 280 290 300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
310 320 330 340 350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI
360 370 380 390 400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ
410 420
VWQMAENIYN DEDTEGGVDP EGQGS
Length:425
Mass (Da):47,569
Last modified:January 23, 2007 - v3
Checksum:i2454C9A19457F5FC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti122 – 1243THD → NHE in AAH77257 (Ref. 2) Curated
Sequence conflicti170 – 1701N → D in AAH77257 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073787 mRNA. Translation: AAC26046.1.
BC077257 mRNA. Translation: AAH77257.1.
RefSeqiNP_001083811.1. NM_001090342.1.
UniGeneiXl.537.

Genome annotation databases

GeneIDi399131.
KEGGixla:399131.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073787 mRNA. Translation: AAC26046.1.
BC077257 mRNA. Translation: AAH77257.1.
RefSeqiNP_001083811.1. NM_001090342.1.
UniGeneiXl.537.

3D structure databases

ProteinModelPortaliO93377.
SMRiO93377. Positions 7-411.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi100456. 2 interactions.

Proteomic databases

PRIDEiO93377.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399131.
KEGGixla:399131.

Organism-specific databases

CTDi399131.
XenbaseiXB-GENE-482006. rbbp4.

Phylogenomic databases

HOVERGENiHBG053236.
KOiK10752.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR022052. Histone-bd_RBBP4_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12265. CAF1C_H4-bd. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional analysis of the SIN3-histone deacetylase RPD3-RbAp48-histone H4 connection in the Xenopus oocyte."
    Vermaak D., Wade P.A., Jones P.L., Shi Y.-B., Wolffe A.P.
    Mol. Cell. Biol. 19:5847-5860(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, INTERACTION WITH HDAC1-B; HISTONE H4 AND SIN3A, SUBCELLULAR LOCATION.
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.
  3. "Multiple N-CoR complexes contain distinct histone deacetylases."
    Jones P.L., Sachs L.M., Rouse N., Wade P.A., Shi Y.-B.
    J. Biol. Chem. 276:8807-8811(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HDAC1; HDAC2; NCOR1 AND SIN3A.

Entry informationi

Entry nameiRBP4A_XENLA
AccessioniPrimary (citable) accession number: O93377
Secondary accession number(s): Q6AZU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.