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Protein

Histone-binding protein RBBP4-A

Gene

rbbp4-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Repressor
Biological processCell cycle, DNA replication, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-binding protein RBBP4-A
Alternative name(s):
Retinoblastoma-binding protein 4-A
Short name:
RBBP-4-A
Retinoblastoma-binding protein p48-A
Gene namesi
Name:rbbp4-a
Synonyms:rbap48-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-482006 rbbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000511902 – 425Histone-binding protein RBBP4-AAdd BLAST424

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiO93377

Interactioni

Subunit structurei

Component of the DREAM complex (By similarity). Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin. Probably forms a large corepressor complex that contains ncor1, sin3a, hdac1-A and/or hdac1-B, hdac2, rbbp4-A and/or rbbp4-B and possibly rbbp7.By similarity

Protein-protein interaction databases

BioGridi100456, 2 interactors
IntActiO93377, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliO93377
SMRiO93377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati122 – 162WD 1Add BLAST41
Repeati175 – 215WD 2Add BLAST41
Repeati225 – 265WD 3Add BLAST41
Repeati271 – 311WD 4Add BLAST41
Repeati315 – 355WD 5Add BLAST41
Repeati372 – 412WD 6Add BLAST41

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

HOVERGENiHBG053236
KOiK10752

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR022052 Histone-bd_RBBP4_N
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12265 CAF1C_H4-bd, 1 hit
PF00400 WD40, 5 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 3 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93377-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL
60 70 80 90 100
SDVTRPDGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS
110 120 130 140 150
EKGEFGGFGS VSGKIEIEIK ITHDGEVNRA RYMPQNPCII ATKTPTSDVL
160 170 180 190 200
VFDYTKHPSK PDPSGECNPN LRLRGHQKEG YGLSWNPNLS GNLLSASDDH
210 220 230 240 250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ
260 270 280 290 300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
310 320 330 340 350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI
360 370 380 390 400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ
410 420
VWQMAENIYN DEDTEGGVDP EGQGS
Length:425
Mass (Da):47,569
Last modified:January 23, 2007 - v3
Checksum:i2454C9A19457F5FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122 – 124THD → NHE in AAH77257 (Ref. 2) Curated3
Sequence conflicti170N → D in AAH77257 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF073787 mRNA Translation: AAC26046.1
BC077257 mRNA Translation: AAH77257.1
RefSeqiNP_001083811.1, NM_001090342.1
UniGeneiXl.537

Genome annotation databases

GeneIDi399131
KEGGixla:399131

Similar proteinsi

Entry informationi

Entry nameiRBP4A_XENLA
AccessioniPrimary (citable) accession number: O93377
Secondary accession number(s): Q6AZU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health