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Protein

T-cell leukemia homeobox protein 3

Gene

TLX3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be involved in the development of cranial sensory innervation from peripheral ganglia.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi172 – 23160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 3
Alternative name(s):
Homeobox TLX-3
Homeobox protein Hox-11L2
Gene namesi
Name:TLX3
Synonyms:HOX11L2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297T-cell leukemia homeobox protein 3PRO_0000049340Add
BLAST

Proteomic databases

PaxDbiO93367.

Expressioni

Tissue specificityi

Expression is restricted to neurons in the peripheral and central nervous system.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003422.

Structurei

3D structure databases

ProteinModelPortaliO93367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 5018Poly-ProAdd
BLAST
Compositional biasi147 – 1504Poly-Ala

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO93367.
PhylomeDBiO93367.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPAAGAQGP HQHEPISFGI DQILSGPEQD GAPPPPPPPP PPPPPPPPPP
60 70 80 90 100
RGPDGAAFLG GPRGGAPYPA LPGPFPAIAA PFEESGPYGV NLSLAPGGVI
110 120 130 140 150
RVPAHRPIPG AVPPPVPSAI PAVPGLGGLS FPWMESSRRF VKERFTAAAA
160 170 180 190 200
LTPFTVTRRI GHPYQNRTPP KRKKPRTSFS RVQICELEKR FHRQKYLASA
210 220 230 240 250
ERAALAKSLK MTDAQVKTWF QNRRTKWRRQ TAEEREAERQ QASRLMLQLQ
260 270 280 290
HDAFQKSLNE SIQPDPLCLH NSSLFALQNL QPWEEESAKI PPVTSLV
Length:297
Mass (Da):32,369
Last modified:November 1, 1998 - v1
Checksum:i0C7C9A73E371A38E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071875 mRNA. Translation: AAC23901.1.
UniGeneiGga.45972.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071875 mRNA. Translation: AAC23901.1.
UniGeneiGga.45972.

3D structure databases

ProteinModelPortaliO93367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003422.

Proteomic databases

PaxDbiO93367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO93367.
PhylomeDBiO93367.

Miscellaneous databases

NextBioi20815934.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity."
    Logan C.C., Wingate R.J.T., McKay I.J., Lumsden A.
    J. Neurosci. 18:5389-5402(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Rhode Island red.

Entry informationi

Entry nameiTLX3_CHICK
AccessioniPrimary (citable) accession number: O93367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.