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Protein

T-cell leukemia homeobox protein 1

Gene

TLX1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to be involved in the development of cranial sensory innervation from peripheral ganglia.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi168 – 22760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell leukemia homeobox protein 1
Alternative name(s):
Homeobox TLX-1
Homeobox protein Hox-11
Gene namesi
Name:TLX1
Synonyms:HOX11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297T-cell leukemia homeobox protein 1PRO_0000049335Add
BLAST

Proteomic databases

PaxDbiO93366.

Expressioni

Gene expression databases

ExpressionAtlasiO93366. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012693.

Structurei

3D structure databases

ProteinModelPortaliO93366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi167 – 1704Poly-Lys

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO93366.
KOiK09340.
PhylomeDBiO93366.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93366-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHLGAHHLH QGQAEPISFG IDQILNTSEP GSCMVSHPRL QDSADYGLGC
60 70 80 90 100
IVGSAYNTVT GGYGASGGGA GAYGGTSCSM GALPGSYNVN MAVSMNGNAL
110 120 130 140 150
SSAGGVIRVP AHRPVAGGVH QPLSAAVPPV NGMNSLTGLT FPWMESNRRY
160 170 180 190 200
TKDRFTGHPY QNRTPPKKKK PRTSFTRLQI CELEKRFHRQ KYLASAERAA
210 220 230 240 250
LAKALKMTDA QVKTWFQNRR TKWRRQTAEE REAERQQANR ILMQLQQEAF
260 270 280 290
QKTINQPIQA DPICVHNSSL FALQNLQPWS DDSTKITSVT TVASACE
Length:297
Mass (Da):32,426
Last modified:November 1, 1998 - v1
Checksum:i2D86A06AA463ADAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071874 mRNA. Translation: AAC23900.1.
RefSeqiNP_990346.1. NM_205015.1.
UniGeneiGga.20979.
Gga.511.

Genome annotation databases

GeneIDi395868.
KEGGigga:395868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071874 mRNA. Translation: AAC23900.1.
RefSeqiNP_990346.1. NM_205015.1.
UniGeneiGga.20979.
Gga.511.

3D structure databases

ProteinModelPortaliO93366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012693.

Proteomic databases

PaxDbiO93366.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395868.
KEGGigga:395868.

Organism-specific databases

CTDi3195.

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
HOGENOMiHOG000116280.
HOVERGENiHBG036206.
InParanoidiO93366.
KOiK09340.
PhylomeDBiO93366.

Miscellaneous databases

NextBioi20815935.
PROiO93366.

Gene expression databases

ExpressionAtlasiO93366. baseline.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity."
    Logan C.C., Wingate R.J.T., McKay I.J., Lumsden A.
    J. Neurosci. 18:5389-5402(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Rhode Island red.

Entry informationi

Entry nameiTLX1_CHICK
AccessioniPrimary (citable) accession number: O93366
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.