Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

O93353 (HXA3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-D3
Gene names
Name:HOXA3
Synonyms:HOXD-3, HOXD3
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 413413Homeobox protein Hox-A3
PRO_0000200045

Regions

DNA binding173 – 23260Homeobox
Motif137 – 1426Antp-type hexapeptide

Experimental info

Sequence conflict1711T → A in AAC19377. Ref.1

Sequences

Sequence LengthMass (Da)Tools
O93353 [UniParc].

Last modified August 21, 2007. Version 2.
Checksum: 0D9245BDEA8D44C8

FASTA41344,756
        10         20         30         40         50         60 
MQKATYYDSS AIYGAYPYQG ANGFTYNASQ QQYPPSSSLV ETEYHRPACS LQSPGSAVSH 

        70         80         90        100        110        120 
HKANDISESC MRTLPSQPLQ PPGLTDPQAP PQPPPAPQAQ PPPPSSASPS QNASSNPAPA 

       130        140        150        160        170        180 
NSTKSPALNS PTVSKQIFPW MKESRQNTKQ KNSSSSSGES CAGDKSPPGQ TSSKRARTAY 

       190        200        210        220        230        240 
TSAQLVELEK EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMMTS 

       250        260        270        280        290        300 
SGGQSPSRSP VPPAAGGYLN SMHSLVNSVP YEPQSPPPFN KPHQNTYGIP ASYTAPLNNC 

       310        320        330        340        350        360 
PPPQKRYTGT AAVTPEYDTH PLQGNGYGNP HIQGSPVYVG GNYVETMTNS GPSIFGLTHL 

       370        380        390        400        410 
SHPPSANMDY SGAGPMGNNH HHGPCDPHPT YTDLTAHHPS QGRIQEAPKL THL 

« Hide

References

[1]"Analysis of Hox gene expression during early avian heart development."
Searcy R.D., Yutzey K.E.
Dev. Dyn. 213:82-91(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Hoxa3 is required for branchial nerve development."
Watari-Goshima N., Chisaka O.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067959 mRNA. Translation: AAC19377.1.
AB111110 mRNA. Translation: BAC77105.1.
RefSeqNP_989879.1. NM_204548.1.
XP_003640749.1. XM_003640701.2.
XP_004939420.1. XM_004939363.1.
XP_004939421.1. XM_004939364.1.
XP_004939422.1. XM_004939365.1.
XP_004939423.1. XM_004939366.1.
UniGeneGga.48467.
Gga.49158.

3D structure databases

ProteinModelPortalO93353.
SMRO93353. Positions 173-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000017983.

Proteomic databases

PaxDbO93353.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000018005; ENSGALP00000017983; ENSGALG00000011054.
ENSGALT00000045994; ENSGALP00000041461; ENSGALG00000027925.
GeneID100858480.
395231.
KEGGgga:100858480.
gga:395231.

Organism-specific databases

CTD3200.

Phylogenomic databases

eggNOGNOG284589.
GeneTreeENSGT00750000117486.
HOGENOMHOG000252944.
HOVERGENHBG107984.
InParanoidO93353.
KOK09303.
OrthoDBEOG754HPS.
PhylomeDBO93353.
TreeFamTF315938.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20815320.

Entry information

Entry nameHXA3_CHICK
AccessionPrimary (citable) accession number: O93353
Secondary accession number(s): Q7T3J5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 21, 2007
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries