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Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi173 – 23260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A3
Alternative name(s):
Homeobox protein Hox-D3
Gene namesi
Name:HOXA3
Synonyms:HOXD-3, HOXD3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 413413Homeobox protein Hox-A3PRO_0000200045Add
BLAST

Proteomic databases

PaxDbiO93353.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017983.

Structurei

3D structure databases

ProteinModelPortaliO93353.
SMRiO93353. Positions 173-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi137 – 1426Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiO93353.
KOiK09303.
OrthoDBiEOG754HPS.
PhylomeDBiO93353.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKATYYDSS AIYGAYPYQG ANGFTYNASQ QQYPPSSSLV ETEYHRPACS
60 70 80 90 100
LQSPGSAVSH HKANDISESC MRTLPSQPLQ PPGLTDPQAP PQPPPAPQAQ
110 120 130 140 150
PPPPSSASPS QNASSNPAPA NSTKSPALNS PTVSKQIFPW MKESRQNTKQ
160 170 180 190 200
KNSSSSSGES CAGDKSPPGQ TSSKRARTAY TSAQLVELEK EFHFNRYLCR
210 220 230 240 250
PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMMTS SGGQSPSRSP
260 270 280 290 300
VPPAAGGYLN SMHSLVNSVP YEPQSPPPFN KPHQNTYGIP ASYTAPLNNC
310 320 330 340 350
PPPQKRYTGT AAVTPEYDTH PLQGNGYGNP HIQGSPVYVG GNYVETMTNS
360 370 380 390 400
GPSIFGLTHL SHPPSANMDY SGAGPMGNNH HHGPCDPHPT YTDLTAHHPS
410
QGRIQEAPKL THL
Length:413
Mass (Da):44,756
Last modified:August 21, 2007 - v2
Checksum:i0D9245BDEA8D44C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711T → A in AAC19377 (PubMed:9733103).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067959 mRNA. Translation: AAC19377.1.
AB111110 mRNA. Translation: BAC77105.1.
RefSeqiNP_989879.1. NM_204548.1.
XP_003640749.1. XM_003640701.2.
XP_004939420.1. XM_004939363.1.
XP_004939421.1. XM_004939364.1.
XP_004939422.1. XM_004939365.1.
XP_004939423.1. XM_004939366.1.
UniGeneiGga.48467.
Gga.49158.

Genome annotation databases

GeneIDi100858480.
395231.
KEGGigga:100858480.
gga:395231.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF067959 mRNA. Translation: AAC19377.1.
AB111110 mRNA. Translation: BAC77105.1.
RefSeqiNP_989879.1. NM_204548.1.
XP_003640749.1. XM_003640701.2.
XP_004939420.1. XM_004939363.1.
XP_004939421.1. XM_004939364.1.
XP_004939422.1. XM_004939365.1.
XP_004939423.1. XM_004939366.1.
UniGeneiGga.48467.
Gga.49158.

3D structure databases

ProteinModelPortaliO93353.
SMRiO93353. Positions 173-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000017983.

Proteomic databases

PaxDbiO93353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100858480.
395231.
KEGGigga:100858480.
gga:395231.

Organism-specific databases

CTDi3200.

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiO93353.
KOiK09303.
OrthoDBiEOG754HPS.
PhylomeDBiO93353.
TreeFamiTF315938.

Miscellaneous databases

NextBioi20815320.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of Hox gene expression during early avian heart development."
    Searcy R.D., Yutzey K.E.
    Dev. Dyn. 213:82-91(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Hoxa3 is required for branchial nerve development."
    Watari-Goshima N., Chisaka O.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHXA3_CHICK
AccessioniPrimary (citable) accession number: O93353
Secondary accession number(s): Q7T3J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: August 21, 2007
Last modified: March 4, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.