O93353 (HXA3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A3

Alternative name(s):
Homeobox protein Hox-D3

Gene names

Name:	HOXA3
Synonyms:	HOXD-3, HOXD3

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	413 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara blood vessel remodeling Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara glossopharyngeal nerve morphogenesis Inferred from electronic annotation. Source: Compara organ formation Inferred from electronic annotation. Source: Compara parathyroid gland development Inferred from electronic annotation. Source: Compara positive regulation of cell proliferation Inferred from electronic annotation. Source: Compara specification of organ position Inferred from electronic annotation. Source: Compara thymus development Inferred from electronic annotation. Source: Compara thyroid gland development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 413	413	Homeobox protein Hox-A3		PRO_0000200045
Regions
	DNA binding	173 – 232	60	Homeobox
	Motif	137 – 142	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	171	1	T → A in AAC19377. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	O93353 [UniParc]. Last modified August 21, 2007. Version 2. Checksum: 0D9245BDEA8D44C8	FASTA	413	44,756
	10 20 30 40 50 60 MQKATYYDSS AIYGAYPYQG ANGFTYNASQ QQYPPSSSLV ETEYHRPACS LQSPGSAVSH 70 80 90 100 110 120 HKANDISESC MRTLPSQPLQ PPGLTDPQAP PQPPPAPQAQ PPPPSSASPS QNASSNPAPA 130 140 150 160 170 180 NSTKSPALNS PTVSKQIFPW MKESRQNTKQ KNSSSSSGES CAGDKSPPGQ TSSKRARTAY 190 200 210 220 230 240 TSAQLVELEK EFHFNRYLCR PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMMTS 250 260 270 280 290 300 SGGQSPSRSP VPPAAGGYLN SMHSLVNSVP YEPQSPPPFN KPHQNTYGIP ASYTAPLNNC 310 320 330 340 350 360 PPPQKRYTGT AAVTPEYDTH PLQGNGYGNP HIQGSPVYVG GNYVETMTNS GPSIFGLTHL 370 380 390 400 410 SHPPSANMDY SGAGPMGNNH HHGPCDPHPT YTDLTAHHPS QGRIQEAPKL THL

References

[1]	"Analysis of Hox gene expression during early avian heart development." Searcy R.D., Yutzey K.E. Dev. Dyn. 213:82-91(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Hoxa3 is required for branchial nerve development." Watari-Goshima N., Chisaka O. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067959 mRNA. Translation: AAC19377.1. AB111110 mRNA. Translation: BAC77105.1.
IPI	IPI00571086.
RefSeq	NP_989879.1. NM_204548.1. XP_003640749.1. XM_003640701.1.
UniGene	Gga.48467. Gga.49158.
3D structure databases
ProteinModelPortal	O93353.
SMR	O93353. Positions 173-232.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000017983.
Proteomic databases
PaxDb	O93353.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000018005; ENSGALP00000017983; ENSGALG00000011054.
GeneID	100858480. 395231.
KEGG	gga:100858480. gga:395231.
Organism-specific databases
CTD	3200.
Phylogenomic databases
eggNOG	NOG284589.
GeneTree	ENSGT00700000104189.
HOGENOM	HOG000252944.
HOVERGEN	HBG107984.
InParanoid	O93353.
KO	K09303.
OrthoDB	EOG4K6G4J.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR025281. DUF4074. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF13293. DUF4074. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815320.

Entry information

Entry name

HXA3_CHICK

Accession

Primary (citable) accession number: O93353
Secondary accession number(s): Q7T3J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	August 21, 2007
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program