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O93353

- HXA3_CHICK

UniProt

O93353 - HXA3_CHICK

Protein

Homeobox protein Hox-A3

Gene

HOXA3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi173 – 23260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A3
    Alternative name(s):
    Homeobox protein Hox-D3
    Gene namesi
    Name:HOXA3
    Synonyms:HOXD-3, HOXD3
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 413413Homeobox protein Hox-A3PRO_0000200045Add
    BLAST

    Proteomic databases

    PaxDbiO93353.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000017983.

    Structurei

    3D structure databases

    ProteinModelPortaliO93353.
    SMRiO93353. Positions 173-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi137 – 1426Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG284589.
    GeneTreeiENSGT00750000117486.
    HOGENOMiHOG000252944.
    HOVERGENiHBG107984.
    InParanoidiO93353.
    KOiK09303.
    OrthoDBiEOG754HPS.
    PhylomeDBiO93353.
    TreeFamiTF315938.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O93353-1 [UniParc]FASTAAdd to Basket

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    MQKATYYDSS AIYGAYPYQG ANGFTYNASQ QQYPPSSSLV ETEYHRPACS    50
    LQSPGSAVSH HKANDISESC MRTLPSQPLQ PPGLTDPQAP PQPPPAPQAQ 100
    PPPPSSASPS QNASSNPAPA NSTKSPALNS PTVSKQIFPW MKESRQNTKQ 150
    KNSSSSSGES CAGDKSPPGQ TSSKRARTAY TSAQLVELEK EFHFNRYLCR 200
    PRRVEMANLL NLTERQIKIW FQNRRMKYKK DQKGKGMMTS SGGQSPSRSP 250
    VPPAAGGYLN SMHSLVNSVP YEPQSPPPFN KPHQNTYGIP ASYTAPLNNC 300
    PPPQKRYTGT AAVTPEYDTH PLQGNGYGNP HIQGSPVYVG GNYVETMTNS 350
    GPSIFGLTHL SHPPSANMDY SGAGPMGNNH HHGPCDPHPT YTDLTAHHPS 400
    QGRIQEAPKL THL 413
    Length:413
    Mass (Da):44,756
    Last modified:August 21, 2007 - v2
    Checksum:i0D9245BDEA8D44C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711T → A in AAC19377. (PubMed:9733103)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067959 mRNA. Translation: AAC19377.1.
    AB111110 mRNA. Translation: BAC77105.1.
    RefSeqiNP_989879.1. NM_204548.1.
    XP_003640749.1. XM_003640701.2.
    XP_004939420.1. XM_004939363.1.
    XP_004939421.1. XM_004939364.1.
    XP_004939422.1. XM_004939365.1.
    XP_004939423.1. XM_004939366.1.
    UniGeneiGga.48467.
    Gga.49158.

    Genome annotation databases

    EnsembliENSGALT00000018005; ENSGALP00000017983; ENSGALG00000011054.
    ENSGALT00000045994; ENSGALP00000041461; ENSGALG00000027925.
    GeneIDi100858480.
    395231.
    KEGGigga:100858480.
    gga:395231.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF067959 mRNA. Translation: AAC19377.1 .
    AB111110 mRNA. Translation: BAC77105.1 .
    RefSeqi NP_989879.1. NM_204548.1.
    XP_003640749.1. XM_003640701.2.
    XP_004939420.1. XM_004939363.1.
    XP_004939421.1. XM_004939364.1.
    XP_004939422.1. XM_004939365.1.
    XP_004939423.1. XM_004939366.1.
    UniGenei Gga.48467.
    Gga.49158.

    3D structure databases

    ProteinModelPortali O93353.
    SMRi O93353. Positions 173-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000017983.

    Proteomic databases

    PaxDbi O93353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000018005 ; ENSGALP00000017983 ; ENSGALG00000011054 .
    ENSGALT00000045994 ; ENSGALP00000041461 ; ENSGALG00000027925 .
    GeneIDi 100858480.
    395231.
    KEGGi gga:100858480.
    gga:395231.

    Organism-specific databases

    CTDi 3200.

    Phylogenomic databases

    eggNOGi NOG284589.
    GeneTreei ENSGT00750000117486.
    HOGENOMi HOG000252944.
    HOVERGENi HBG107984.
    InParanoidi O93353.
    KOi K09303.
    OrthoDBi EOG754HPS.
    PhylomeDBi O93353.
    TreeFami TF315938.

    Miscellaneous databases

    NextBioi 20815320.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR025281. DUF4074.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF13293. DUF4074. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of Hox gene expression during early avian heart development."
      Searcy R.D., Yutzey K.E.
      Dev. Dyn. 213:82-91(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Hoxa3 is required for branchial nerve development."
      Watari-Goshima N., Chisaka O.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiHXA3_CHICK
    AccessioniPrimary (citable) accession number: O93353
    Secondary accession number(s): Q7T3J5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1999
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3