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Protein

Retinal dehydrogenase 2

Gene

ALDH1A2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).By similarity

Catalytic activityi

Retinal + NAD+ + H2O = retinoate + NADH.

Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei187 – 1871Transition state stabilizerBy similarity
Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation
Active sitei320 – 3201NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi263 – 2686NADBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiR-GGA-5365859. RA biosynthesis pathway.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal dehydrogenase 2 (EC:1.2.1.36)
Short name:
RALDH 2
Short name:
RalDH2
Alternative name(s):
Aldehyde dehydrogenase family 1 member A2
Retinaldehyde-specific dehydrogenase type 2
Short name:
RALDH(II)
Gene namesi
Name:ALDH1A2
Synonyms:RALDH2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 518518Retinal dehydrogenase 2PRO_0000056425Add
BLAST

Proteomic databases

PaxDbiO93344.

Expressioni

Gene expression databases

BgeeiENSGALG00000004270.
ExpressionAtlasiO93344. baseline and differential.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033786.

Structurei

3D structure databases

ProteinModelPortaliO93344.
SMRiO93344. Positions 20-518.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO93344.
KOiK07249.
OMAiKPIANAY.
OrthoDBiEOG091G05E8.
PhylomeDBiO93344.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93344-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSKIEMPG EVKADPAALM ASLHLLPSPT LNLEIKHTKI FINNEWQNSE
60 70 80 90 100
SGRVFPVYNP ATGEQICEIQ EADKVDTDKA VRAARLAFSL GSVWRRMDAS
110 120 130 140 150
ERGQLLDKLA DLVERDRAVL ATMESLNSGK PFLQAFYVDL QGVIKTLRYY
160 170 180 190 200
AGWADKIHGM TIPVDGDYFT FTRHEPIGVC GQIIPWNFPL LMFAWKIAPA
210 220 230 240 250
LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP GFGPIVGAAI
260 270 280 290 300
ASHVGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD
310 320 330 340 350
LDYAVEQAHQ GVFFNQGQCC TAGSRIYVEE SIYEEFVRRS VERAKRRVVG
360 370 380 390 400
SPFDPTTEQG PQIDKKQYNK ILELIQSGIT EGAKLECGGK GLGRKGFFIE
410 420 430 440 450
PTVFSNVTDD MRIAKEEIFG PVQEILRFKT VDEVIERANN SDFGLVAAVF
460 470 480 490 500
TNDINKALTV SSAMQAGTVW INCYNALNAQ SPFGGFKMSG NGREMGESGL
510
REYSEVKTVT IKIPQKNS
Length:518
Mass (Da):56,732
Last modified:March 7, 2006 - v2
Checksum:iB79FBA3124592460
GO

Sequence cautioni

The sequence AAC34299 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064253 mRNA. Translation: AAC34299.1. Different initiation.
AF181680 mRNA. Translation: AAF00485.2.
RefSeqiNP_990326.1. NM_204995.1.
UniGeneiGga.2996.

Genome annotation databases

EnsembliENSGALT00000006791; ENSGALP00000006780; ENSGALG00000004270.
GeneIDi395844.
KEGGigga:395844.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064253 mRNA. Translation: AAC34299.1. Different initiation.
AF181680 mRNA. Translation: AAF00485.2.
RefSeqiNP_990326.1. NM_204995.1.
UniGeneiGga.2996.

3D structure databases

ProteinModelPortaliO93344.
SMRiO93344. Positions 20-518.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033786.

Proteomic databases

PaxDbiO93344.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000006791; ENSGALP00000006780; ENSGALG00000004270.
GeneIDi395844.
KEGGigga:395844.

Organism-specific databases

CTDi8854.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiO93344.
KOiK07249.
OMAiKPIANAY.
OrthoDBiEOG091G05E8.
PhylomeDBiO93344.

Enzyme and pathway databases

UniPathwayiUPA00912.
ReactomeiR-GGA-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiO93344.

Gene expression databases

BgeeiENSGALG00000004270.
ExpressionAtlasiO93344. baseline and differential.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1A2_CHICK
AccessioniPrimary (citable) accession number: O93344
Secondary accession number(s): Q549A6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.