Reviewed, UniProtKB/Swiss-Prot O93344 (AL1A2_CHICK)

Names and origin

Protein names

Recommended name:
    Retinal dehydrogenase 2
      Short name=RALDH 2
      Short name=RalDH2
    EC=1.2.1.36
Alternative name(s):
    Aldehyde dehydrogenase family 1 member A2
    Retinaldehyde-specific dehydrogenase type 2
      Short name=RALDH(II)

Gene names

Name:	ALDH1A2
Synonyms:	RALDH2

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	518 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently By similarity.
Catalytic activity	Retinal + NAD(+) + H(2)O = retinoate + NADH.
Pathway	Cofactor metabolism; retinol metabolism.
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	retinal dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 518	518	Retinal dehydrogenase 2		PRO_0000056425
Regions
	Nucleotide binding	263 – 268	6	NAD By similarity
Sites
	Active site	286	1	Proton acceptor By similarity
	Active site	320	1	Nucleophile By similarity
	Site	187	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	O93344-1 [UniParc]. Last modified March 7, 2006. Version 2. Checksum: B79FBA3124592460	FASTA	518	56,732
	10 20 30 40 50 60 MTSSKIEMPG EVKADPAALM ASLHLLPSPT LNLEIKHTKI FINNEWQNSE SGRVFPVYNP 70 80 90 100 110 120 ATGEQICEIQ EADKVDTDKA VRAARLAFSL GSVWRRMDAS ERGQLLDKLA DLVERDRAVL 130 140 150 160 170 180 ATMESLNSGK PFLQAFYVDL QGVIKTLRYY AGWADKIHGM TIPVDGDYFT FTRHEPIGVC 190 200 210 220 230 240 GQIIPWNFPL LMFAWKIAPA LCCGNTVVIK PAEQTPLSAL YMGALIKEAG FPPGVVNILP 250 260 270 280 290 300 GFGPIVGAAI ASHVGIDKIA FTGSTEVGKL IQEAAGRSNL KRVTLELGGK SPNIIFADAD 310 320 330 340 350 360 LDYAVEQAHQ GVFFNQGQCC TAGSRIYVEE SIYEEFVRRS VERAKRRVVG SPFDPTTEQG 370 380 390 400 410 420 PQIDKKQYNK ILELIQSGIT EGAKLECGGK GLGRKGFFIE PTVFSNVTDD MRIAKEEIFG 430 440 450 460 470 480 PVQEILRFKT VDEVIERANN SDFGLVAAVF TNDINKALTV SSAMQAGTVW INCYNALNAQ 490 500 510 SPFGGFKMSG NGREMGESGL REYSEVKTVT IKIPQKNS

References

[1]	"Motor neuron-derived retinoid signaling specifies the subtype identity of spinal motor neurons." Sockanathan S., Jessell T.M. Cell 94:503-514(1998) [PubMed: 9727493] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	Capdevila J. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 20-518.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF064253 mRNA. Translation: AAC34299.1. Different initiation. AF181680 mRNA. Translation: AAF00485.2.
RefSeq	NP_990326.1.
UniGene	Gga.2996
3D structure databases
HSSP	HSSP built from PDB template 1BI9 based on UniProtKB Q63639.
ModBase	Search...
Genome annotation databases
Ensembl	ENSGALG00000004270. Gallus gallus. [Contig view]
GeneID	395844.
KEGG	gga:395844.
Phylogenomic databases
HOGENOM	O93344.
HOVERGEN	O93344.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AL1A2_CHICK

Accession

Primary (citable) accession number: O93344
Secondary accession number(s): Q549A6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1999
Last sequence update:	March 7, 2006
Last modified:	November 4, 2008
This is version 54 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)