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Protein
Submitted name:

N-methyl-D-aspartate receptor NR1 subunit

Gene
N/A
Organism
Apteronotus leptorhynchus
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
N-methyl-D-aspartate receptor NR1 subunitImported
OrganismiApteronotus leptorhynchusImported
Taxonomic identifieri36674 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiGymnotiformesSternopygoideiApteronotidaeApteronotus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei578 – 59619HelicalSequence analysisAdd
BLAST
Transmembranei651 – 67323HelicalSequence analysisAdd
BLAST
Transmembranei829 – 85325HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 966947Sequence analysisPRO_5004160520Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO93338.
SMRiO93338. Positions 414-816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini451 – 811361PBPeInterPro annotationAdd
BLAST
Domaini457 – 52367Lig_chan-Glu_bdInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG052638.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Complete.

O93338-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLALAVFF SYSCVRVDCE PKIVNIGAVL SQKRYEQVFK DAVNQANVVY
60 70 80 90 100
GRDKFKLTAI SVTHKANAIQ MALSVCEDLI SSQVYAILVS HPPQSSDHLT
110 120 130 140 150
PTPVSYTAGF YRIPVVGLTT RMSIYSDKSI HLSFLRTVPP YSHQAHVWFD
160 170 180 190 200
MMREFRWNHI ILVVSDDHEG RAAQKRLETL LEERETKNKK RNYENLDQLS
210 220 230 240 250
YDNKRGPKAE KVLQFNQETN LTTLLLEAKE LEARVIILSA SEEDAAAVYK
260 270 280 290 300
TARFLNMTGS GYVWLVGERE MSGKALSEAP DGLIGLQLIN GKNESAHISD
310 320 330 340 350
AVGVVAQSIQ ELFEKENITE PPRGCVGNTN IWKTGPLFKR VLMSSKYPEG
360 370 380 390 400
LTGRVEFNDD GDRKYAHYSI LNYQKSRLVQ VGIYNGTQVV LNKQRKIIWP
410 420 430 440 450
GGETERPRGF QMSTRLKIVT IHQEPFVYVK PTLMDGTCKE EHTPNGVLIK
460 470 480 490 500
KVICTGPNET IPGRPTVPQC CYGFCIDLLI KLAMTMNFTY EVHLVADGKF
510 520 530 540 550
GTQERVNNSN KKEWNGMMGE LLGGLADMIV APLTINNERA QYIEFSKPFK
560 570 580 590 600
YQGPTILVKK EIPRSTLDSF MQPFQSTLWL LVGLSVHVVA VMLYLLDRFS
610 620 630 640 650
PFGRFKVNSE EEEEDALTLS SAMWFSWGVL LNSGIGEGAP RSFSARILGM
660 670 680 690 700
VWAGFAMIIV ASYTANLAAF LVLDRPEERI TGINDPRLRN PSDKFIYATV
710 720 730 740 750
KQSSVDIYFR RQVELSTMYR HMEKHNYESA AEAIQAVRDN KLHAFIWDSA
760 770 780 790 800
VLEFEASQKC DLVTTGELFF RSGFGIGMRK DSPWKQNVSL AILSSHENGF
810 820 830 840 850
MEDLDKTWVR YQECDSRSNA PATLTFENMA GVFMLVAGGI AAGIFLIFIE
860 870 880 890 900
IAYKRHKDAR GKQMQLAFAA VNVWRKNLQD NKESAGSQIA GAAGTPSLPS
910 920 930 940 950
SSVETQDDRK SGRADPEPKK KASFRSISST LATSIKRRRS SKDTQYPPTD
960
ITGQLNLSDP SVSTVV
Length:966
Mass (Da):108,412
Last modified:November 1, 1998 - v1
Checksum:iB84059D3EFA83081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060557 mRNA. Translation: AAC33440.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060557 mRNA. Translation: AAC33440.1.

3D structure databases

ProteinModelPortaliO93338.
SMRiO93338. Positions 414-816.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG052638.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "N-methyl-D-aspartate receptor 1 mRNA distribution in the central nervous system of the weakly electric fish Apteronotus leptorhynchus."
    Bottai D., Dunn R.J., Ellis W., Maler L.
    J. Comp. Neurol. 389:65-80(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "Alternative RNA splicing of the NMDA receptor NR1 mRNA in the neurons of the teleost electrosensory system."
    Bottai D., Maler L., Dunn R.J.
    J. Neurosci. 18:5191-5202(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiO93338_9TELE
AccessioniPrimary (citable) accession number: O93338
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.