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Protein

Heparan sulfate 2-O-sulfotransferase 1

Gene

hs2st1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand-binding interactions and signaling processes (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei140By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionTransferase

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan sulfate 2-O-sulfotransferase 1 (EC:2.8.2.-)
Gene namesi
Name:hs2st1
Synonyms:hs2st
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5953205. hs2st1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini29 – 356LumenalSequence analysisAdd BLAST328

GO - Cellular componenti

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076781 – 356Heparan sulfate 2-O-sulfotransferase 1Add BLAST356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 209By similarity
Disulfide bondi222 ↔ 228By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO93336.
SMRiO93336.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 3 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053202.
KOiK02513.

Family and domain databases

InterProiView protein in InterPro
IPR007734. Heparan_SO4_2-O-STrfase.
IPR027417. P-loop_NTPase.
IPR005331. Sulfotransferase.
PANTHERiPTHR12129. PTHR12129. 1 hit.
PfamiView protein in Pfam
PF03567. Sulfotransfer_2. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

O93336-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLRIMMPP KLQLLAVLTF GVLMLFLENQ IQNLEESREK LERAIARHEV
60 70 80 90 100
REIEQRHSMD GSRQEIALDD DEDILIIYNR VPKTASTSFT NIAYDLCAKN
110 120 130 140 150
KYHVLHINTT KNNPVMSLQD QVRFVKNVSS WREMKPGFYH GHVSFLDFTK
160 170 180 190 200
FGVKKKPIYI NVIRDPIERL VSYYYFLRFG DDYRPGLRRR KQGDKKTFDE
210 220 230 240 250
CVAAGGSDCA PEKLWLQIPF FCGHSSECWN VGSRWALDQA KYNLVNEYFL
260 270 280 290 300
VGVTEELEDF IMLLEAALPR FFRGATELYR SGKKSHLRKT TEKKAPSKET
310 320 330 340 350
TAKLQQSDIW KMENEFYEFA LEQFQFVRAH AVREKDGELY VLAPNFFYEK

IYPKSN
Length:356
Mass (Da):41,749
Last modified:November 1, 1998 - v1
Checksum:iFEBA74FCF4ACC8AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF060179 mRNA. Translation: AAC41301.1.
BC078097 mRNA. Translation: AAH78097.1.
RefSeqiNP_001083748.1. NM_001090279.1.
UniGeneiXl.51140.

Genome annotation databases

GeneIDi399095.
KEGGixla:399095.

Similar proteinsi

Entry informationi

Entry nameiHS2ST_XENLA
AccessioniPrimary (citable) accession number: O93336
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 1, 1998
Last modified: May 10, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families