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Protein

Cytochrome P450 26A1

Gene

cyp26a1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a key role in retinoic acid metabolism.1 Publication

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi437Iron (heme axial ligand)Sequence analysis1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 26A1 (EC:1.14.13.-By similarity)
Alternative name(s):
Retinoic acid-converting enzyme
Short name:
RACE
Retinoic acid-degrading enzyme CYP26
Short name:
xCYP26
Gene namesi
Name:cyp26a1
Synonyms:cyp26
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000519841 – 492Cytochrome P450 26A1Add BLAST492

Expressioni

Inductioni

By retinoic acid.1 Publication

Structurei

3D structure databases

ProteinModelPortaliO93323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG051099.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLYTLLTSA LCTLALPLLL LLTAAKLWEV YCLRRKDAAC ANPLPPGTMG
60 70 80 90 100
LPFFGETLQM VLQRRRFLQV KRSQYGRIYK THLFGSPTVR VTGAENVRQI
110 120 130 140 150
LMGEHKLVSV HWPASVRTIL GAGCLSNLHD NEHKYTKKVI AQAFSREALA
160 170 180 190 200
NYVPQMEEEV RCSVNLWLQS GPCVLVYPAI KRMMFRIAMR LLLGCDPQRM
210 220 230 240 250
DREQEETLLE AFEEMSRNLF SLPIDVPFSG LYRGLRARNL IHAQIEENIK
260 270 280 290 300
EKLQREPDEH CKDALQLLID YSRRNGEPIN LQALKESATE LLFGGHGTTA
310 320 330 340 350
SAATSLTSFL ALHKDVLEKV RKELETQGLL STKPEEKKEL SIEVLQQLKY
360 370 380 390 400
TSCVIKETLR LSPPVAGGFR VALKTFVLNG YQIPKGWNVI YSIADTHGEA
410 420 430 440 450
DLFPDTDKFN PDRFLTPLPR DSSRFGFIPF GGGVRCCIGK EFAKILLKVF
460 470 480 490
VVELCRNCDW ELLNGSPAMT TSPIICPVDN LPAKFKPFSS SI
Length:492
Mass (Da):55,460
Last modified:November 1, 1998 - v1
Checksum:iD1D4BB7651BF2D3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057566 mRNA. Translation: AAC25158.1.
UniGeneiXl.456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF057566 mRNA. Translation: AAC25158.1.
UniGeneiXl.456.

3D structure databases

ProteinModelPortaliO93323.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051099.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP26A_XENLA
AccessioniPrimary (citable) accession number: O93323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1998
Last modified: October 5, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.