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Protein

Cadherin-11

Gene

CDH11

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-11
Gene namesi
Name:CDH11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini54 – 613560ExtracellularSequence analysisAdd
BLAST
Transmembranei614 – 63421HelicalSequence analysisAdd
BLAST
Topological domaini635 – 792158CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Propeptidei23 – 5331Sequence analysisPRO_0000003789Add
BLAST
Chaini54 – 792739Cadherin-11PRO_0000003790Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi455 – 4551N-linked (GlcNAc...)Sequence analysis
Glycosylationi536 – 5361N-linked (GlcNAc...)Sequence analysis
Glycosylationi594 – 5941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Proteomic databases

PaxDbiO93319.
PRIDEiO93319.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008451.

Structurei

3D structure databases

ProteinModelPortaliO93319.
SMRiO93319. Positions 55-375, 721-782.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 159106Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini160 – 268109Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini269 – 383115Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini384 – 486103Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini487 – 608122Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiO93319.
KOiK06803.
PhylomeDBiO93319.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O93319-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEDNCLHAA LICLGMLYYS HAITTEKLNH VRPSLHGHHE KGKEGQVLHR
60 70 80 90 100
SKRGWVWNQF FVIEEYTGPD PVLVGRLHSD IDSGDGNIKY ILSGEGAGII
110 120 130 140 150
FVIDDKSGNI HATKTLDREE RAQYTLTAQA VDRNTNRPLE PPSEFIVKVQ
160 170 180 190 200
DINDNPPEFL HENYHANVPE RSNVGTSVIQ VTASDADDPT YGNSAKLVYS
210 220 230 240 250
ILEGQPYFSV EAQTGIIRTA LPNMDREAKE EYHVVIQAKD MGGHMGGLSG
260 270 280 290 300
TTKVTITLTD VNDNPPKFPQ SVYQMSVSEA AVPGEEVGRV KAKDPDIGEN
310 320 330 340 350
GLVAYSIIDG DGMDMFEITT DYETQEGVVK LKKVLDFETK KSYSLKVEAA
360 370 380 390 400
NVHIDPKFIS NGPFKDTVTV KITVEDADEP PVFLKPSYIF EVQENAASGT
410 420 430 440 450
VVGKVHAKDP DAANSAIRYS IDRHTDLERY FTINADDGNI KTIKALDREE
460 470 480 490 500
IAWHNISVFA VEVHKQHQEA KVPVAIKVVD VNDNAPKFAA AYEAFVCENA
510 520 530 540 550
RSNQQFITIS ADDKDDSANG PRFIFSLPPE IIHNPNFSLR DNRDNTASVL
560 570 580 590 600
VRREGFSRQK QDLYLLPIVI SDGGLPPMSS TNTLTIRVCG CDSNGSLLSC
610 620 630 640 650
NAEAYILNAG LSTGALIAIL ACIVILLVIV VLFVTLKRQK KEPLIVFEEE
660 670 680 690 700
DVRENIITYD DEGGGEEDTE AFDIATLQNP DGINGFIPRK DIKPEYQYMP
710 720 730 740 750
RPGLRPAPNS VDVDDFINTR IQEADNDPTA PPYDSIQIYG YEGRGSVAGS
760 770 780 790
LSSLESATTD SDLDYDYLQN WGPRFKKLAD LYGSKDTFDD DS
Length:792
Mass (Da):87,573
Last modified:November 1, 1998 - v1
Checksum:i3E3488C6686731AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055342 mRNA. Translation: AAC33675.1.
RefSeqiNP_001004371.1. NM_001004371.1.
UniGeneiGga.4941.

Genome annotation databases

GeneIDi415797.
KEGGigga:415797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF055342 mRNA. Translation: AAC33675.1.
RefSeqiNP_001004371.1. NM_001004371.1.
UniGeneiGga.4941.

3D structure databases

ProteinModelPortaliO93319.
SMRiO93319. Positions 55-375, 721-782.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008451.

Proteomic databases

PaxDbiO93319.
PRIDEiO93319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415797.
KEGGigga:415797.

Organism-specific databases

CTDi1009.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
HOGENOMiHOG000231252.
HOVERGENiHBG005217.
InParanoidiO93319.
KOiK06803.
PhylomeDBiO93319.

Miscellaneous databases

PROiO93319.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAD11_CHICK
AccessioniPrimary (citable) accession number: O93319
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1998
Last modified: June 8, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.