O93315 (O93315_CYPCA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Glucokinase EMBL AAC33587.2
EC=2.7.1.2 EMBL AAC33587.2

Gene names

Name:

GK EMBL AAC33587.2

Organism

Cyprinus carpio (Common carp) EMBL AAC33587.2

Taxonomic identifier

7962 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Otocephala › Ostariophysi › Otophysi › Cypriniphysi › Cypriniformes › Cyprinoidea › Cyprinidae › Cyprinus

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672 RuleBase RU004049
Ligand	ATP-binding SAAS SAAS022672 RuleBase RU004049 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 RuleBase RU004049 EMBL AAC33587.2 Transferase
Gene Ontology (GO)
Biological_process	detection of glucose Inferred from sequence or structural similarity. Source: UniProtKB glucose homeostasis Inferred from sequence or structural similarity. Source: UniProtKB glycolysis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of gluconeogenesis Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of glycogen biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of insulin secretion Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB glucokinase activity Inferred from sequence or structural similarity. Source: UniProtKB glucose binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	O93315 [UniParc]. Last modified October 1, 2000. Version 2. Checksum: 2DBC9E35A0FCADBE	FASTA	476	53,562
	10 20 30 40 50 60 MPCLSSARRQ RTPSDFESVL ERILMVDQIL SESLLSKEDL EEVMRRIRRE MERGLRVETH 70 80 90 100 110 120 DEASVKMLPT YVRSTPEGSE VGDFLALDLG GTNFRVMLVK VGEDEERGWK VETKHHMYSI 130 140 150 160 170 180 PEDAMTGTAE MLFDYIASCI SDFLDKHNLK HKKLPLGFTF SFPVRHEDLD KGILLNWTKG 190 200 210 220 230 240 FKASGAEGNN VVGLLRDAIK RRGDFEMDVV AMVNDTVATM ISCYYEDRSC EVGMIVGTGC 250 260 270 280 290 300 NACYMEEMRK VELVEGEEGR MCVNTEWGAF GDNGELEDFR LEYDRVIDET SLNPGHQLYE 310 320 330 340 350 360 KLIGGKYMGE LARLVLLKPV NENLLFNGDA SDLLKTRGAF ETRFVSQIES DTGDRKQIYN 370 380 390 400 410 420 ILSSLGILPS ELDCDIVRLV CESVSTRAAH MCGAGLAGVI NLMRERRCQE ELKITVGVDG 430 440 450 460 470 SVYKLHPHFK ERFHKLVWEM TPHCEITFIQ SEEGSGRGAA LISAVACKMA ACMLTP

References

[1]

"Molecular cloning, tissue specificity and sequence analysis of complete glucokinase cDNA in rainbow trout, common carp and gilthead seabream." Panserat S., Blin C., Medale F., Breque J., Plagnes-Juan E., Krishnamoorthy R., Kaushik S. Biochim. Biophys. Acta 1474:61-69(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Liver EMBL AAC33587.2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF053332 mRNA. Translation: AAC33587.2.
3D structure databases
HSSP	HSSP built from PDB template 1QHA based on UniProtKB P19367.
ProteinModelPortal	O93315.
SMR	O93315. Positions 25-470.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG000142.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O93315_CYPCA

Accession

Primary (citable) accession number: O93315

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1998
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)