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Protein
Submitted name:

T-box containing protein

Gene

tbx16

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: ZFIN
  • transcription factor activity, sequence-specific DNA binding Source: InterPro
  • transcription regulatory region DNA binding Source: ZFIN

GO - Biological processi

  • angiogenesis Source: ZFIN
  • convergent extension involved in nephron morphogenesis Source: ZFIN
  • determination of left/right symmetry Source: ZFIN
  • embryonic heart tube morphogenesis Source: ZFIN
  • erythrocyte development Source: ZFIN
  • erythrocyte differentiation Source: ZFIN
  • heart looping Source: ZFIN
  • hematopoietic stem cell differentiation Source: ZFIN
  • intermediate mesoderm development Source: ZFIN
  • Kupffer's vesicle development Source: ZFIN
  • mesodermal to mesenchymal transition involved in gastrulation Source: ZFIN
  • mesoderm development Source: ZFIN
  • myeloid cell development Source: ZFIN
  • pronephric duct morphogenesis Source: ZFIN
  • pronephric glomerulus morphogenesis Source: ZFIN
  • pronephros development Source: ZFIN
  • regulation of BMP signaling pathway involved in heart jogging Source: ZFIN
  • somatic muscle development Source: ZFIN
  • somitogenesis Source: ZFIN
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: ZFIN
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
T-box containing proteinImported
Gene namesi
Name:tbx16Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-990615-5. tbx16.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

  • nucleus Source: ZFIN
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PaxDbiO93303.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003051.

Structurei

3D structure databases

ProteinModelPortaliO93303.
SMRiO93303. Positions 32-213.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains T-box DNA-binding domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOVERGENiHBG003537.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O93303-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIRDLKHN FSLPPPPSMP GAGDSYHQGN IRMTLEDPEL WRSFHEIGTE
60 70 80 90 100
MIITKPGRRM FPHCKISLSG LVPYAKYILL VDMVPEDGLR YKWNKDKWEV
110 120 130 140 150
AGKAEPQPPY RTYLHPDSPA PGSHWMKQPV SFLKLKLTNN ALDQHGHIIL
160 170 180 190 200
HSMHRYHPRF HIVQADDLYS VRWSVFQTFT FPETSFTAVT AYQNTKITKL
210 220 230 240 250
KIDHNPFAKG FRDEGTNSKR RANRNLPDPE RVAKKMSKES THGSPRDVQP
260 270 280 290 300
SSCEALDDEH AGRKELEVKA ERYSPWGGAC DRDSGHALRP ESPLGSDHRD
310 320 330 340 350
VFSSEQLVPG QNTYQPYRFH EYGKSPSPSS SSSVGGSSAC GSAGRPSFES
360 370 380 390 400
RVLDVATVPD TDSSSKPSSA PEFSLPPHPS AGHQEYAGVL NMAITQAKPG
410 420 430 440 450
MLGTHPLYSH YSTEQSLGQW SGAAASQYPP PPPPHHHLPT EYSNQAVHHG
460 470
YHHGNVGEWS QYPLFSYSCW
Length:470
Mass (Da):52,619
Last modified:November 1, 1998 - v1
Checksum:iE45618BA2E1491E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044977 mRNA. Translation: AAC25499.1.
UniGeneiDr.75456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF044977 mRNA. Translation: AAC25499.1.
UniGeneiDr.75456.

3D structure databases

ProteinModelPortaliO93303.
SMRiO93303. Positions 32-213.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003051.

Proteomic databases

PaxDbiO93303.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ZFINiZDB-GENE-990615-5. tbx16.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
HOVERGENiHBG003537.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the zebrafish tbx16 gene and evolution of the vertebrate T-box family."
    Ruvinsky I., Silver L.M., Ho R.K.
    Dev. Genes Evol. 208:94-99(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiO93303_DANRE
AccessioniPrimary (citable) accession number: O93303
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1998
Last sequence update: November 1, 1998
Last modified: May 11, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.